Search for functional food elements that regulate epigenetics and prevent life-related diseases

• Project/Area Number: 19500709
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Mukogawa Women's University
• Principal Investigator: XU Jim-wen Mukogawa Women's University, 薬学部, 助手 (50373121)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 生活習慣病予防 / エピジェネティクス / 機能食品成分 / 老化 / 高血圧自然発症ラットSHR / 生活習慣病 / 高血糖による内皮細胞の老化 / ヒストンのメチル化 / レニンの発現

Research Abstract

本研究では、細胞レベルで40 種余りのポリフェノールをスクリーンし、3種類が濃度依存的にヒストンH3K9 メチル化を阻害することを証明した。 また、高血圧ラットにおける血管老化現象に、長寿遺伝子SIRT1 の Ser47 の脱リン酸化の関与を見出し、この脱リン酸化はH3K9 メチル化の酵素SUV39H1 とコンプレックスの状態にも関連することから、その遺伝子変異体を作成し細胞導入を行いうことにより、老化現象を再確認した。

Research Products

• [Journal Article] SirT1 dephosphorylation accesses the epigenetic status of TERT and aortal senescence (2009)
  • Author(s): Jin-Wen Xu, et al
  • Journal Title: Circulation Research (掲載確定)
  • Peer Reviewed
• [Journal Article] Isoflavones Regulate Secretion of Leukemia Inhibitory Factor and Transforming Growth Factor β and Expression of Glycodelin in HumanEndometrial Epithelial Cells (2008)
  • Author(s): Jin-Wen Xu, Naomi Yasui, Katsumi Ikeda, Wei-Jun Pan, June Watanabe, Masahide Shiotani, Atsushi Yanaihara, Yukio Yamori
  • Journal Title: J Endocrinol 196(2) Pages: 425-433
  • Peer Reviewed
• [Journal Article] Isoflavones Regulate Secretion of Leukemia Inhibitory Factor and Transforming Growth Factor beta and Expression of Glvcodelin in Human Endometrial Epithelial Cells (2008)
  • Author(s): Jin-Wen Xu, など
  • Journal Title: J Endocrinol 196(2) Pages: 425-33
  • Peer Reviewed
• [Journal Article] Inhibitory effect of polyphenol cyanidingon TNF-α-induced apoptosis through multiple signaling pathways in endothelial cells. (2007)
  • Author(s): Jin-Wen Xu, Katsumi Ikeda, and Yukio Yamori
  • Journal Title: Atherosclerosis 193(2) Pages: 299-308
• [Journal Article] Oleic Acid Inhibits C-Reactive Protein-Induced Expression of Inducible Nitric Oxide Synthase in Rat Aortic Smooth Muscle Cells. (2007)
  • Author(s): Jin-Wen Xu, Katsumi Ikeda, Takao Ikami, Yukio Yamori
  • Journal Title: CliniExperi Pharmacol Physiol. 34(S1)
  • Peer Reviewed
• [Journal Article] Effects of prune extract on blood pressure elevation in Stroke-Prone Spontaneously Hypertensive Rats. (2007)
  • Author(s): Hiroko Negishi, Yuko Onobayashi, Jin-Wen Xu, Marina Alois Njelekela, Akira Kobayakawa, naomi Yasui, Junko Yamamoto, Takao Ikami, Katsumi Ikeda and Yukio Yamori
  • Journal Title: Clini Experi Pharmacol Physiol. 34(S1)
  • Peer Reviewed
• [Journal Article] Inhibitory effect of polyphenol cyanidin on TNF-alpha-induced apoptosis through multiple signaling pathways in endothelial cells (2007)
  • Author(s): Jin-Wen Xu, など
  • Journal Title: Atherosclerosis 193(2) Pages: 299-308
  • Peer Reviewed
• [Journal Article] Oleic Acid Inhibits C-Reactive Protein-Induced Expression of Inducible Nitric Oxide Synthase in Rat Aortic Smooth Muscle Cells (2007)
  • Author(s): Jin-Wen Xu, など
  • Journal Title: Clini Experi Pharmacol Physiol 34(S1) Pages: 58-60
  • Peer Reviewed
• [Journal Article] Effects of prune extract on blood pressure elevation in Stroke-Prone Spontaneously Hypertensive Rats (2007)
  • Author(s): Hiroko Negishi, Yuko Onobayashi, Jin-WenXu, など
  • Journal Title: Clini Experi Pharmacol Physiol 34(S1) Pages: 47-48
  • Peer Reviewed
• [Journal Article] SirT1 dephosphorylation accesses the epigenetic status of TERT and aortal senescence in spontaneously hypertensive rats.
  • Author(s): Jin-Wen Xu, Naomi Yasui, Yukio Yamori, and Katsumi Ikeda
  • Journal Title: Circulation Research. 投稿中 Pages: 0-0
  • Peer Reviewed
• [Presentation] Blood Vessel Senescence-Epigenetic Regulation in SHR. (2008)
  • Author(s): Xu JW, Yasui N, Yamori Y, Ikeda K
  • Organizer: The13thInternational SHR Symposium
  • Place of Presentation: Prague
• [Presentation] SirT1 dephosphorylation accesses the epigenetic status of TERT and aortal senescence. (2008)
  • Author(s): Jin-Wen Xu, et al
  • Organizer: 第13回国際SHR シンポジウム
  • Place of Presentation: プラハ、チェコ共和国
• [Presentation] Blood Vessel Senescence-Epigenetic Regulation in SHR (2008)
  • Author(s): Xu JW, Yasui N, Yamori Y, Ikeda K.
  • Organizer: The 13^<th> International SHR Symposium
  • Place of Presentation: チェコ、プラハ
• [Presentation] Isoflavones Regulate Secretion of Leukemia Inhibitory Factor and Transforming Growth Factor and Expression of Glycodelin in Human Endometrial Epithelial Cells. (2007)
  • Author(s): Jin-Wen Xu, Naomi Yasui, Katsumi Ikeda , Wei-Jun Pan, June Watanabe, Masahide Shiotani, Atsushi Yanaihara, Tomohiro Miki, Yukio Yamori
  • Organizer: The AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE 63rd Annual Meeting
  • Place of Presentation: Washington DC, USA.
• [Presentation] Isoflavones Regulate Secretion of Leukemia Inhibitory Factor and Transforming Growth Factor and Expression of Glycodelin in Human Endometrial Epithelial Cells. (2007)
  • Author(s): Jin-Wen Xu, Naomi Yasui, Katsumi Ikeda, Wei-Jun Pan, June Watanabe, Masahide Shiotani, Atsushi Yanaihara, Tomohiro Miki, Yukio Yamori
  • Organizer: The 2nd Asian PacificCongress on Controversies in Obstetrics Gynecology & Infertility
  • Place of Presentation: Shanghai, China
• [Presentation] ヒト子宮内膜上皮細胞におけるLIFとTGF-beta分泌とGlycodelin発現に対すイソフラボンの調節作用 (2007)
  • Author(s): 許 錦文、安井菜穂美、池田克巳、潘偉軍、渡部純江、塩谷雅英、矢内原敦、三木知博、家森幸男
  • Organizer: 第52回日本生殖医学会総会・学術講演会
  • Place of Presentation: 秋田
• [Presentation] 血管内皮細胞におけるSykを介したアンジオテンシンIIのシングナル伝達 (2007)
  • Author(s): 許 錦文、安井菜穂美、池田克巳、三木知博、家森幸男
  • Organizer: 第30回日本高血圧学会総会
  • Place of Presentation: 沖縄
• [Presentation] 血管内皮細胞におけるSykを介したアンジオテンシンIIのシングナル伝達 (2007)
  • Author(s): 許 錦文、安井菜穂美、池田克巳、三木知博、家森幸男
  • Organizer: 第43回高血圧関連疾患モデル学会
  • Place of Presentation: 大阪
• [Presentation] Isoflavones Regulate Secretion of Leukemia Inhibitory Factor and Transforming GrowthFactor and Expression of Glycodelin in Human Endometriai Epithelial Cells (2007)
  • Author(s): Jin-Wen Xu, など
  • Organizer: The AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE 63rd Annual Meeting
  • Place of Presentation: Washington DC,USA
• [Presentation] Isoflavones Regulate Secretion of Leukemia Inhibitory Factor and Transforming GrowthFactor and Expression of Glycodelin in Human Endometriai Epithelial Cells (2007)
  • Author(s): Jin-Wen Xu, など
  • Organizer: The 2nd Asian Pacific Congress on Controversies in Obstetrics Gvnecoloev&Infertility(COGI)
  • Place of Presentation: Shanghai,China
• [Presentation] 血管内皮細胞におけるSykを介したアンジオテンシンIIのシングナル伝達 (2007)
  • Author(s): Jin-Wen Xu, など
  • Organizer: 第30回日本高血圧学会総会
  • Place of Presentation: 沖縄コンベンションセンター
• [Presentation] 血管内皮細胞におけるSykを介したアンジオテンシンIIのシングナル伝達 (2007)
  • Author(s): Jin-Wen Xu, など
  • Organizer: 第43回高血圧関連疾患モデル学会
  • Place of Presentation: 大阪梅田スカイビル