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Studies on molecular mechanisms of thalidomide-induced teratogenesis using human mesenchymal tem cells

Research Project

Project/Area Number 19510076
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionNational Institute of Health Sciences

Principal Investigator

TAKAGI Atsuya  National Institute of Health Sciences, 毒性部, 室長 (00179417)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsサリドマイド / 間葉系幹細胞 / マイクロアレイ / 遺伝子 / ヒト / マウス / 発生・分化
Research Abstract

There are many proposed mechanisms of action in thalidomide teratogenicity including inhibition of angiogenesis or oxidative DNA damage. We have undertaken a microarray gene expression analysis on human mesenchymal stem cells and mouse mesenchymal stem like cells treated with thalidomide. No clear changes of gene expression including oxidative stress were observed (10μM thalidomide) in the human cells. On the other hand, dose-dependent decrease of a long non-coding RNA was observed in mouse mesenchymal stem like cells (10-300μM thalidomide).

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report

Research Products

(5 results)

All 2009 2008 2007

All Presentation (5 results)

  • [Presentation] Percellome 手法によるマウスES細胞分化過程における遺伝子発現の経時データベースの構築と活用2009

    • Author(s)
      高木篤也
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Percellome手法によるマウスES細胞分化過程における遺伝子発現の経時データベースの構築と活用2009

    • Author(s)
      高木篤也、北嶋聡、五十嵐勝秀、相崎健一、菅野純
    • Organizer
      第32回日本分子生物学科会年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Quantitative microarray analysis by "Percellome" method on murine embryonic stem cells and embryoid bodies2008

    • Author(s)
      TAKAGI A, KITAJIMA S, NAKATSU N, IGARASHI K, AISAKI K, EMA M, KANNO J
    • Organizer
      47^<th> Annual Meeting of Society of Toxicology
    • Place of Presentation
      USA
    • Related Report
      2009 Final Research Report
  • [Presentation] マウス口蓋形成過程に発現する遺伝子のPercellome手法を用いた定量的マイクロアレイ解析2007

    • Author(s)
      高木篤也、中津則之、五十嵐勝秀、相崎健一、菅野純
    • Organizer
      第30回日本分子生物学科会年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] マウスES細胞分化系における分化マーカー遺伝子発現パターンの解析(その2)2007

    • Author(s)
      高木篤也、北嶋聡、中津則之、五十嵐勝秀、相崎健一、菅野純
    • Organizer
      第34回日本トキシコロジー学会学術年会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report

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Published: 2007-03-31   Modified: 2016-04-21  

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