| Project/Area Number |
19510211
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Living organism molecular science
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
KITAJIMA Mariko Chiba University, 大学院・薬学研究院, 准教授 (60195261)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOGURE Noriyuki 千葉大学, 大学院・薬学研究院, 助教 (80396689)
NAKAMURA Tomonori 群馬大学, 大学院・医学系研究科, 准教授 (30251151)
|
|---|
| Project Period (FY) |
2007 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 天然物化学 / アルカロイド / 構造解析 / 化学変換 / 細胞毒性 / インドール / マチン科 / 構造変換 / イリドイド / Gelsemium / Gelsedine / Humantenine / 腫瘍細胞 |
|---|
| Research Abstract |
To discover and develop lead compound for new antitumor agent origenated from plant alkaloids, chemical investigation and biological evaluation of Gelsemium alkaloids were carried out. As a result, several new alkaloids having novel structures were isolated from Gelsemium plants. Chemical transformation of a humantenine-type alkaloid to gelsedine-type alkaloids was accomplished. Yohimbane-type alkaloids showed the cytotoxic effects on some human tumor cells.
|
