Synthesis of glutamine transporter inhibitors regulating amino acids concentrations in neurotransmission system
| Project/Area Number |
19510228
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Suntory Institute for Bioorganic Research |
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Principal Investigator |
SHIMAMOTO Keiko Suntory Institute for Bioorganic Research, 研究員 (70235638)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | グルタミン / トランスポーター / 阻害剤 / グリア細胞 / 立体配座固定 / グルタミン酸 / 中性アミノ酸 / シスチン / ヘテロエクスチェンジ |
|---|
| Research Abstract |
Extracellular concentrations of amino acids and sugars are regulated by transporters. In order to elucidate physiological roles in neurotransmission system and substrate recognition mechanisms of these transporters, we synthesized selective inhibitors for neutral amino acid transporter (ASCT2) and glutamate-cyctine exchanger (xCT).
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Report
(4 results)
Research Products
(13 results)
