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Synthetic studies of long-acting nano-particles toward a novel malaria vaccine to realize the immunity condition in malaria endemic area

Research Project

Project/Area Number 19550158
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemistry related to living body
Research InstitutionGunma University

Principal Investigator

OKU Hiroyuki  群馬大学, 大学院・工学研究科, 准教授 (20301749)

Co-Investigator(Kenkyū-buntansha) 狩野 繁之  国立国際医療センター研究所, 適正技術開発移転研究部, 部長 (60233912)
山田 圭一  群馬大学, 大学院・工学研究科, 助教 (70323334)
花岡 宏史  群馬大学, 医学系研究科, 助教 (50361390)
Co-Investigator(Renkei-kenkyūsha) KANO Shigeyuki  国立国際医療研究センター, 研究所・熱帯医学・マラリア研究部, 部長 (60233912)
YANO Kazuhiko  国立国際医療研究センター, 研究所・熱帯医学・マラリア研究部, 上級研究員 (30392393)
YAMADA Keiichi  群馬大学, 大学院・工学研究科, 助教 (70323334)
HANAOKA Hirofumi  群馬大学, 大学院・医学系研究科, 助教 (50361390)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords薬物徐放性材料 / 生体機能材料 / ペプチド / マラリア / 微粒子 / ナノスフェア / 高分子合成化学 / 生体関連化学 / バイオイメージング / 寄生虫学
Research Abstract

Malaria is the major cause of mortality and morbidity in the tropical and subtropical regions in the world. We have designed a slow-releasing vaccination material to realize the immunity condition in endemic area, in which residents are infected, in average, six times in a year and thus sustain immunity against parasite infection. As an example of the slow-releasing material, we have made a polymer nano-sphere containing a peptide antigen.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (85 results)

All 2011 2010 2009 2008 2007

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (50 results) Patent(Industrial Property Rights) (12 results) (of which Overseas: 1 results)

  • [Journal Article] Partial Peptide Sequences from Plasmodium falciparum Enolase as Synthetic Artificial Antigens2011

    • Author(s)
      T. Horie, M. Urano, K. Yamada, H. Oku, K. Yano, S. Kano.
    • Journal Title

      In Peptide Science 2010, Y. Kiso & N. Fujii Eds.; Protein Research Foundation : Osaka

      Volume: 89

    • NAID

      10028237421

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nano-Encapsulation and Immunological Properties for a Peptide Antigen from Plasmodium falciparum Enolase Toward an All-Synthetic Malaria Vaccine2011

    • Author(s)
      H. Oku, K. Yano, M. Fukumoto, S. Kano.
    • Journal Title

      In Peptide Science 2010, Y. Kiso & N. Fujii Eds.; Protein Research Foundation : Osaka

      Pages: 101-101

    • NAID

      10028237437

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nano-Encapsulation and Immunological Properties for a Peptide Antigen from Plasmodium falciparum Enolase Toward an All-Synthetic Malaria Vaccine.2011

    • Author(s)
      Hiroyuki Oku, Kazuhiko Yano, Megumi Fukumoto, Shigeyuki Kano
    • Journal Title

      Peptide Science

      Volume: 2010(In press)

    • NAID

      10028237437

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Partial Peptide Sequences from Plasmodium falciparum Enolase as Synthetic Artificial Antigens.2011

    • Author(s)
      Toru Horie, Shota Sato, Tetsuro Demura, Ayano Iwasaki, Masashi Urano, Keiichi Yamada, Hiroyuki Oku, Ichiro Matsuo Shin Hasegawa, Yasunari Maekawa, Kazuhiko Yano, Shigeyuki Kano
    • Journal Title

      Peptide Science

      Volume: 2010(In press)

    • NAID

      10028237421

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nano-Particle Materials Prepared From a Synthetic Antigenic Sequence of Plasmodium falciparum Enolase2009

    • Author(s)
      H. Oku, K. Yamada, K. Kobayashi, R. Katakai, M. Ashfaq, H. Hanaoka, Y. Iida, K. Endo, S. Hasegawa, Y. Maekawa, K. Yano, S. Kano, M .Suzuki.
    • Journal Title

      In Peptide Science 2008, M. Nomizu, Ed.; Protein Research Foundation : Osaka

      Pages: 422-439

    • NAID

      10027166661

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and Properties of Polymeric Micelles Consisting of Depsipeptide-Poly(Ethylene Glycol) Block Copolymer for Drug Delivery2009

    • Author(s)
      Sunaga, H., Oku, H., Yamada, K., Katakai, R., Matsuo, I.
    • Journal Title

      Peptide Scienece 2008 ; M. Nomizu Ed.; The Japanese Peptide Society : Osaka

      Pages: 501-504

    • NAID

      10027166772

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nano-Particle Materials Prepared From a Synthetic Antigenic Sequence of Plasmodium falciparum Enolase. Peptide Scienece 20082009

    • Author(s)
      Oku, H., Yamada, K., Hanaoka, H., Kano, S., ら.
    • Journal Title

      The Japanese Peptide Society(M. Nomizu Ed.)

      Pages: 439-442

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Synthesis and Properties of Polymeric Micelles Consisting of Depsipeptide-Poly (Ethylene Glycol) Block Copolymer for Drug Delivery. Peptide Scienece 2008 ; M. Nomizu Ed.2009

    • Author(s)
      Sunaga, H., Oku, H., Yamada, K., ら.
    • Journal Title

      The Japanese Peptide Society : Osaka

      Pages: 501-504

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Synthesis and Properties of Polymeric Micelles Consisting of Depsipeptide-Poly(Ethylene Glycol) Block Copolymer for Drug Delivery.2009

    • Author(s)
      Hiroaki Sunaga
    • Journal Title

      Peptide Science 2008

      Pages: 501-504

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nano-Particle Materials Prepared From a Synthetic Antigenic Sequence of Plasmodium falciparum Enolase.2009

    • Author(s)
      Hiroyuki Oku
    • Journal Title

      Peptide Science 2008

      Pages: 439-442

    • NAID

      10027166661

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Konjac Glucomannan-Based Hydrogel with Hyaluronic Acid as a Candidate for a Novel Scaffold for Chondrocyte Culture.2009

    • Author(s)
      Kondo Takashi
    • Journal Title

      J.Tisssue Engineering & Regenerative Medicine 3

      Pages: 361-367

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and properties of polymeric micelles consisting of depsipetide-poly(ethylene glycol) block copolymer for drug delivery2009

    • Author(s)
      H. Sunaga, H. Oku, K. Yamada, R. Katakai, I. Matsuo
    • Journal Title

      Peptide Science 2008

      Pages: 501-504

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peroxiredoxins in Malaria Parasites : Parasitologic Aspects2008

    • Author(s)
      S. Kawazu, K. Komaki-Yasuda, H. Oku, K. Kano.
    • Journal Title

      Parasitology International

      Pages: 1-7

    • NAID

      10020150795

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conformational Change from α-Helix to β-Sheet Observed in a Series of Depsipeptide Crystals : Synthesis and Structural Properties of Boc-Leu-Lac-OEt and Boc-(Leu-Leu-Lac)n-OEt(n=1, 2).2008

    • Author(s)
      H. Oku, K. Yamada, R. Katakai.
    • Journal Title

      Biopolymers

      Volume: Vol.89 Pages: 270-283

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of Micelles Consisting of Sequential Depsipeptide-block poly(ethylene glycol) to Drug Delivery System.2008

    • Author(s)
      M. Komoriya, H. Sunaga, S. Asano, K. Yamada, H. Oku, R. Katakai.
    • Journal Title

      Peptide Scienece 2007 ; S. Aimoto & S. Ono, Eds.; The Japanese Peptide Society : Osaka

      Pages: 477-480

    • NAID

      10021907363

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and Properties of Novel Amphiphilic Block Copolymers Consisting of Metal Ion Coordinating Depsipeptides and Poly(ethylene glycol)2008

    • Author(s)
      K. Arai, H. Oku, K. Yamada, H. Hanaoka, Y. Iida, K. Endo, K. Kohama, R. Katakai.
    • Journal Title

      Peptide Scienece 2007 ; S. Aimoto & S. Ono, Eds.; The Japanese Peptide Society : Osaka

      Pages: 437-440

    • NAID

      10021907282

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and Properties of a Novel Thermo-Responsible Block Copolymer Composed of Elastin-Like-Depsipeptide2008

    • Author(s)
      C. Takayama, A. Inoue, Y. Shimoda, H. Oku, K. Yamada, R. Katakai.
    • Journal Title

      Peptide Scienece 2007 ; S. Aimoto & S. Ono, Eds.; The Japanese Peptide Society : Osaka

      Pages: 433-436

    • NAID

      10021907273

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of a Novel Polydepsipeptide, Poly(Ala-Ile-Gly-Lac-Pro)(Lac=L-Lactic Acid) Which Shows Irreversible Thermo-Responding Behavior2008

    • Author(s)
      Y. Shimoda, A. Inoue, C. Takayama, H. Oku, , K. Yamada, R. Katakai.
    • Journal Title

      Peptide Scienece 2007 ; S. Aimoto & S. Ono, Eds.; The Japanese Peptide Society : Osaka

      Pages: 429-430

    • NAID

      10021907265

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conformational Change from α-Helix to β-Sheet Observed in a Series of Depsipeptide Crystals : Synthesis and Structural Properties of Boc-Leu-Lac-OEt and Boc-(Leu-Leu-Lac)n-OEt (n=1, 2)2008

    • Author(s)
      Oku, H., Yamada, K., 他.
    • Journal Title

      Biopolymers 89

      Pages: 270-283

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Synthesis of a Novel Polydepsipeptide, Poly (Ala-Ile-Gly-Lac-Pro) (Lac=L-Lactic Acid) Which Shows Irreversible Thermo-Responding Behavior. Peptide Scienece 2007 ; S. Aimoto & S. Ono, Eds.2008

    • Author(s)
      Shimoda, Y., Yamada, K., Oku, H., 他.
    • Journal Title

      The Japanese Peptide Society : Osaka

      Pages: 429-430

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Application of Micelles Consisting of Sequential Depsipeptide-block-poly (ethylene glycol) to Drug Delivery System. Peptide Scienece 2007 ; S. Aimoto & S. Ono, Eds.2008

    • Author(s)
      Komoriya, M., Yamada, K., Oku, H., 他.
    • Journal Title

      The Japanese Peptide Society : Osaka

      Pages: 477-480

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Conformational change from antiparallel beta-sheet to alpha-helix in a series of depsipeptide,-(Leu-Leu-Lac)n-: syntheses,spectroscopic studies,and crystal structures of Boc-Leu-Lac-OEt and Boc-(Leu-1、eu-Lac)n.OEt(n=1,2).2008

    • Author(s)
      Hiroyuki Oku, et. al.
    • Journal Title

      Biopolymers 89

      Pages: 270-283

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peroxiredoxins in malaria parasites: parasitologic aspects2008

    • Author(s)
      Shin-ichiro Kawazu, et. al.
    • Journal Title

      Parasitology International 57

      Pages: 1-7

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 熱帯熱マラリア原虫エノラーゼ由来人工抗原ペプチド生分解性ナノ微粒子を用いた抗原徐放性マラリアワクチンの開発2011

    • Author(s)
      矢野和彦, 福本恵, 奥浩之, 狩野繁之
    • Organizer
      第80 回日本寄生虫学会大会および第22回日本臨床寄生虫学会大会(合同大会)
    • Year and Date
      2011-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 熱帯熱マラリア原虫エノラーゼ由来人工抗原ペプチド生分解性ナノ微粒子を用いた抗原徐放性マラリアワクチンの開発2011

    • Author(s)
      矢野和彦、福本恵、奥浩之、狩野繁之
    • Organizer
      第80回日本寄生虫学会大会および第22回日本臨床寄生虫学会大会(合同大会)
    • Place of Presentation
      東京慈恵会医科大学(東京都)
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 熱帯熱マラリア原虫由来人工抗原ペプチド生分解性微粒子を用いたワクチン開発研究2010

    • Author(s)
      矢野和彦、福本恵、奥浩之、.狩野繁之
    • Organizer
      第51回熱帯医学会大会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nano-Encapsulation and Immunological Properties for a Peptide Antigen from Plasmodium falciparum Enolase Toward an All-Synthetic Malaria Vaccine.2010

    • Author(s)
      Hiroyuki Oku, Kazuhiko Yano, Megumi Fukumoto, Shigeyuki Kano
    • Organizer
      5th International Peptide Symposium(第47回ペプチド討論会)
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-12-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Partial Peptide Sequences from Plasmodium falciparum Enolase as Synthetic Artificial Antigens.2010

    • Author(s)
      Toni Hone, Shota Sato, Tetsuro Demura, Ayano Iwasaki, Masashi Urano, Keiichi Yamada, Hiroyuki Oku, Ichiro Matsuo Shin Hasegawa, Yasunari Maekawa, Kazuhiko Yano, Shigeyuki Kano
    • Organizer
      5th International Peptide Symposium(第47回ペプチド討論会)
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-12-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nano-Encapsulation and Immunological Properties for a Peptide Antigen from Plasmodium falciparum Enolase Toward an All-Synthetic Malaria Vaccine2010

    • Author(s)
      Hiroyuki Oku, Kazuhiko Yano, Megumi Fukumoto, Shigeyuki Kano.
    • Organizer
      5th International Peptide Symposium(第47回ペプチド討論会)
    • Place of Presentation
      国立京都国際会館、京都市
    • Year and Date
      2010-12-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Partial Peptide Sequences from Plasmodium falciparum Enolase as Synthetic Artificial Antigens2010

    • Author(s)
      Toru Horie, Shota Sato, Tetsuro Demura, Ayano Iwasaki, Masashi Urano, Keiichi Yamada, Ichiro Matsuo, Hiroyuki Oku, Shin Hasegawa, Yasunari Maekawa, Kazuhiko Yano, Shigeyuki Kano
    • Organizer
      5th International Peptide Symposium(第47回ペプチド討論会)
    • Place of Presentation
      国立京都国際会館、京都市
    • Year and Date
      2010-12-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 熱帯熱マラリア原虫由来人工抗原ペプチド生分解性微粒子を用いたワクチン開発研究2010

    • Author(s)
      矢野和彦, 福本恵, 奥浩之, 狩野繁之
    • Organizer
      第51回日本熱帯医学会大会
    • Place of Presentation
      仙台国際センター、仙台市
    • Year and Date
      2010-12-03
    • Related Report
      2010 Final Research Report
  • [Presentation] An All-synthetic nanosphere vaccine targeting Plasmodium falciparum enolase induces potent and long lasting antibody titers in mice2010

    • Author(s)
      Hiroyuki Oku, Kazuhiko Yano, Megumi Fukumoto, Shigeyuki Kano
    • Organizer
      ASTMH 59th Annual Meeting (第59回米国熱帯医学会)
    • Place of Presentation
      アトランタ、米国
    • Year and Date
      2010-11-04
    • Related Report
      2010 Final Research Report
  • [Presentation] An All-synthetic nanosphere vaccine targeting Plasmodium falciparum enolase induces potent and long lasting antibody titers in mice.2010

    • Author(s)
      Hiroyuki Oki, Kazuhiko Yano, Megumi Fukumoto, Shigeyuki Kano
    • Organizer
      ASTMH 59th Annual Meeting #166 Noon-1:30pm
    • Place of Presentation
      Marriott Atlanta Marquis Hotel Atlanta, GA, USA
    • Year and Date
      2010-11-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Preparation and Immunological Properties of Nanosphere Materials Containing a Synthetic Peptide Antigen from Plasmodium falciparum Enolase2010

    • Author(s)
      Hiroyuki Oku, Kazuhiko Yano, Megumi Fukumoto, Shigeyuki Kano
    • Organizer
      第59回高分子学会年次大会(英語による口頭発表)
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2010-05-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Preparation and Immunological Properties of Nanosphere Materials Containing a Synthetic Peptide Antigen from Plasmodium falciparum Enolase2010

    • Author(s)
      Hiroyuki Oku, Kazuhiko Yano, Megumi Fukumoto, Shigeyuki Kano
    • Organizer
      第59回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜(横浜市) (英語による口頭発表)
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 熱帯熱マラリア原虫由来人工抗原ペプチド生分解性ナノ微粒子を用いたマラリアワクチン開発研究2010

    • Author(s)
      矢野和彦, 福本恵, 奥浩之(群馬大学工学研究科), 狩野繁之
    • Organizer
      第79回日本寄生虫学会大会
    • Place of Presentation
      大雪クリスタルホール、旭川市
    • Year and Date
      2010-05-21
    • Related Report
      2010 Final Research Report
  • [Presentation] 熱帯熱マラリア原虫由来人工抗原ペプチド生分解性ナノ微粒子を用いたマラリアワクチン開発研究2010

    • Author(s)
      矢野和彦、福本恵、奥浩之、狩野繁之
    • Organizer
      第79回日本寄生虫学会大会および
    • Place of Presentation
      旭川市大雪クリスタルホール(旭川市)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] A Non-Adjuvanted Polypeptide Nanoparticle Vaccine Targeting Plasmodium falciparum Enolase Continues to Induce High Antibody Titers In Mice2010

    • Author(s)
      Shigeyuki Kano, Kazuhiko Yano, Megumi Fukumoto, Hiroyuki Oku
    • Organizer
      The Adaptive and Innate Immune Responses to Neglected Tropical Diseases Conference, The U. S.-Japan Cooperative Medical Sciences Program(日米医学協力会議)
    • Place of Presentation
      米国サンディエゴ市
    • Year and Date
      2010-01-10
    • Related Report
      2010 Final Research Report
  • [Presentation] A Non-Adjuvanted Polypeptide Nanoparticle Vaccine Targeting Plasmodium falciparum Enolase Continues to Induce High Antibody Titers In Mice2010

    • Author(s)
      Kano, S., Oku, H., et al.
    • Organizer
      The Adaptive and Innate Immune Responses to Neglected Tropical Diseases Conference, The U.S. - Japan Cooperative Medical Sciences Program (日米医学協力会議)
    • Place of Presentation
      サンディエゴ
    • Year and Date
      2010-01-10
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] A Non-Adjuvanted Polypeptide Nanoparticle Vaccine Targeting Plasmodium falciparum Enolase Continues to Induce High Antibody Titers In Mice2010

    • Author(s)
      Shigeyuki Kano
    • Organizer
      The US-Japan Cooperative Medical Sciences Program
    • Place of Presentation
      米国、サンディエゴ市
    • Year and Date
      2010-01-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Nanosphere Materials Containing a Synthetic Antigenic Peptide Sequence of Plasmodium falciparum Enolase2009

    • Author(s)
      Hiroyuki Oku, Kazuhiko Yano, Megumi Fukumoto, Shigeyuki Kano
    • Organizer
      The Joint International Tropical Medicine Meeting (JITMM2009)
    • Place of Presentation
      タイ王国、バンコク
    • Year and Date
      2009-12-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Nanosphere Materials Containing a Synthetic Antigenic Peptide Sequence of Plasmodium Falciparum Enolas2009

    • Author(s)
      Oku, H., Kano, S., et al.
    • Organizer
      The Joint International Tropical Medicine Meeting2009 (JITMM2009), Centara Grand Bangkok
    • Place of Presentation
      バンコク、タイ王国
    • Year and Date
      2009-12-04
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] NANOSPHERE MATERIALS CONTAINING A SYNTHETIC ANTIGENIC PEPTIDE SEQUENCE OF Plasmodium falciparum ENOLASE2009

    • Author(s)
      Hiroyuki Oku
    • Organizer
      The Joint International Tropical Medicine Meeting 2009(JITMM2009)
    • Place of Presentation
      Centara Grand Bangkok(バンコク、タイ王国)
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 熱帯熱マラレア原虫由来人工抗原ペプチド生分解性ナノ微粒子を用いたワクチン開発研究2009

    • Author(s)
      矢野和彦
    • Organizer
      第50回日本熱帯医学会大会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 熱帯熱マラリア原虫由来人工抗原ペプチド生分解性ナノ微粒子を用いたワクチン開発研究2009

    • Author(s)
      矢野和彦, 福本恵, 奥浩之, 狩野繁之
    • Organizer
      第50回日本熱帯医学会大会
    • Place of Presentation
      沖縄コンベンションセンター、沖縄県宜野湾市
    • Year and Date
      2009-10-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 熱帯熱マラリアエノラーゼ由来人工抗原ペプチドを用いた生分解性ナノ微粒子のマラリアワクチンへの応用研究2009

    • Author(s)
      矢野和彦, 福本恵, 奥浩之, 狩野繁之
    • Organizer
      第69回日本寄生虫学会東日本支部大会
    • Place of Presentation
      国立国際医療センター、東京都新宿区
    • Year and Date
      2009-10-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 熱帯熱マラレアエノラーゼ由来人工抗原ペプチドを用いた生分解性ナノ微粒子のマラリアワクチンへの応用研究2009

    • Author(s)
      矢野和彦
    • Organizer
      第69回日本寄生虫学会東日本支部大会
    • Place of Presentation
      国立国際医療センター(東京都新宿区)
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生体分解性高分子に内包させた熱帯熱マラリア原虫に由来する人工抗原の微粒子材料の作成と性質2009

    • Author(s)
      奥浩之, 矢野和彦, 福本恵, 狩野繁之
    • Organizer
      第17回分子寄生虫学ワークショップ
    • Place of Presentation
      草津セミナーハウス、群馬県草津町
    • Year and Date
      2009-08-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 生体分解性高分子に内包させた熱帯熱マラリア原虫に由来する人工抗原の微粒子材料の作成と性質2009

    • Author(s)
      奥浩之
    • Organizer
      第17回分子寄生虫ワークショップ
    • Place of Presentation
      草津セミナーハウス(群馬県草津町)
    • Year and Date
      2009-08-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 化学の視点から見たマラリアへの対策と研究2009

    • Author(s)
      奥浩之
    • Organizer
      財団法人群馬大学科学技術振興会・平成21年度科技振セミナー
    • Place of Presentation
      群馬大学工学部(桐生市)
    • Year and Date
      2009-07-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 熱帯熱マラリア原虫に由来する人工抗原を含んだ微粒子の作成と性質2009

    • Author(s)
      奥浩之, 山田圭一, 片貝良一, 鈴木守, 矢野和彦, 狩野繁之
    • Organizer
      平成21年度繊維学会年次大会研究発表会
    • Place of Presentation
      タワーホール江戸堀、東京都江戸川区
    • Year and Date
      2009-06-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 熱帯熱マラリア原虫に由来する人工抗原を含んだ微粒子の作成と性質2009

    • Author(s)
      奥浩之, 山田圭一, 狩野繁之, ら.
    • Organizer
      平成21年度繊維学会年次大会研究発表会
    • Place of Presentation
      東京都江戸川区
    • Year and Date
      2009-06-10
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 熱帯熱マラリア原虫に由来する人工抗原を含んだ微粒子の作成と性質2009

    • Author(s)
      奥浩之
    • Organizer
      平成21年度繊維学会年次大会研究発表会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2009-06-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 熱帯熱マラリア原虫に由来する抗原ペプチドのナノ微粒子化と抗原性に関する研究2009

    • Author(s)
      奥浩之, 矢野和彦, 花岡宏史, 長谷川伸, 山田圭一, 片貝良一, 飯田靖彦, 遠藤啓吾, 前川康成, 狩野繁之, 鈴木守
    • Organizer
      日本化学会第89春期年会
    • Place of Presentation
      日本大学、千葉県船橋市
    • Year and Date
      2009-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 熱帯熱マラリア原虫に由来する抗原ペプチドのナノ微粒子化と抗原性に関する研究2009

    • Author(s)
      奥浩之, 花岡宏史, 山田圭一, 狩野繁之, ら.
    • Organizer
      日本化学会第89春期年会
    • Place of Presentation
      船橋市
    • Year and Date
      2009-03-29
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 熱帯熱マラリアエノラーゼ由来人工抗原ペプチドを用いた生分解性ナノ微粒子の特性解析2009

    • Author(s)
      矢野和彦, 奥浩之, 山田圭一, 片貝良一, 鈴木守, 狩野繁之
    • Organizer
      第78回日本寄生虫学会大会
    • Place of Presentation
      法政大学、東京都千代田区
    • Year and Date
      2009-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] セグメント縮合法による温度応答性デプシペプチド-ポリエチレングリコール複合体の合成と機能評価2009

    • Author(s)
      高山千恵・奥浩之・山田圭一・松尾一郎
    • Organizer
      第23回高分子学会群馬栃木地区講演会
    • Place of Presentation
      桐生市
    • Year and Date
      2009-03-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 熱帯熱マラリア原虫に由来する抗原ペプチドの蛍光標識化とナノ微粒子研究2008

    • Author(s)
      奥浩之, 山田圭一, 片貝良一, 花岡宏史, 飯田靖彦, 遠藤啓吾, 長谷川伸, 前川康成, 矢野和彦, 狩野繁之, 鈴木守
    • Organizer
      第8回放射性医薬品・画像診断薬研究会
    • Place of Presentation
      京都テルサ、京都市
    • Year and Date
      2008-12-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 熱帯熱マラリア原虫に由来する抗原ペプチドの蛍光標識化とナノ微粒子研究2008

    • Author(s)
      奥浩之, 山田圭一, 花岡宏史, 狩野繁之, ら.
    • Organizer
      第8回放射性医薬品・画像診断薬研究会
    • Place of Presentation
      京都市
    • Year and Date
      2008-12-06
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 酵素構造に学ぶ-生分解性高分子からマラリアワクチンまで2008

    • Author(s)
      奥浩之
    • Organizer
      首都圏北部四大学発 新技術説明会
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2008-11-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 熱帯熱マラリア原虫由来の人口抗原を用いたナノ微粒子研究2008

    • Author(s)
      奥浩之, 山田圭一, 小林京子, 片貝良一, 花岡宏史, 飯田靖彦, 遠藤啓吾, 長谷川伸, 前川康成, 矢野和彦, 狩野繁之, 鈴木守
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      タワーホール江戸堀、東京都江戸川区
    • Year and Date
      2008-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 熱帯熱マラリア原虫由来の人工抗原を用いた生分解性ナノ微粒子の作成と性質2008

    • Author(s)
      奥浩之, 山田圭一, 片貝良一, 花岡宏史, 飯田靖彦, 遠藤啓吾, 矢野和彦, 狩野繁之, 鈴木守
    • Organizer
      第68回日本寄生虫学会東日本支部大会
    • Place of Presentation
      アクトシティ浜松、静岡県浜松市
    • Year and Date
      2008-10-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 熱帯熱マラリア原虫由来の人工抗原を用いた生分解性ナノ微粒子の作成と性質2008

    • Author(s)
      奥浩之, 山田圭一, 花岡宏史, 狩野繁之, ら.
    • Organizer
      第67回日本寄生虫学会東日本支部大会
    • Place of Presentation
      浜松市
    • Year and Date
      2008-10-04
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 熱帯熱マラリア原虫由来の人工抗原を内包した生分解性ナノ微粒子に関する研究2008

    • Author(s)
      奥浩之, 山田圭一, 片貝良一, 花岡宏史, 飯田靖彦, 遠藤啓吾, 長谷川伸, 前川康成, 矢野和彦, 狩野繁之, 鈴木守
    • Organizer
      第3回分子イメージング学会
    • Place of Presentation
      大宮ソニックシティ、埼玉県さいたま市
    • Year and Date
      2008-05-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 熱帯熱マラリア原虫由来の人工抗原を内包した生分解性ナノ微粒子に関する研究2008

    • Author(s)
      奥浩之, 山田圭一, 花岡宏史, 狩野繁之, ら.
    • Organizer
      第3回分子イメージング学会
    • Place of Presentation
      さいたま市
    • Year and Date
      2008-05-23
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 熱帯熱マラリア原虫由来の人工抗原を内包した生分解性ナノ微粒子に関する研究2008

    • Author(s)
      奥浩之、山田圭一、片貝良一、花岡宏史、他8名
    • Organizer
      日本分子イメージング学会第3回総会学術集会
    • Place of Presentation
      さいたま市
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] Synthesis of a Novel Polydepsipeptide, Poly(Ala-Ile-Gly-Lac-Pro)(Lac=L-Lacti cacid)Which Shows Irreversible Thermo-responding Behavior2007

    • Author(s)
      Yuya Shimoda, et. al.
    • Organizer
      44th Japanese Peptide Symposium
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2007-11-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] 抗マラリア原虫薬としてのアンホテリシンBの蛍光標識化研究2007

    • Author(s)
      山口武志, 奥浩之, 山田圭一, 片貝良一, 畑生俊光, 嶋田淳子, 川合覚, 狩野繁之
    • Organizer
      日本化学会第1回関東支部大会
    • Place of Presentation
      首都大学東京、東京都八王子市
    • Year and Date
      2007-11-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Synthesis and Anti-plasmodial Properties of an Amphotericin B and Carboxyfluorescein Conjugate2007

    • Author(s)
      Takeshi Yamaguchi, Hiroyuki Oku, Keiichi Yamada, Ryoichi Katakai, Toshimitsu Hatabu, Junko Shimada, Satoru Kawai, Shigeyuki Kano
    • Organizer
      群馬国際化学シンポジウム(The 2ndGunma International Symposium on Chemistry,GIS2007, Pre-ISNA-12)
    • Place of Presentation
      群馬大学工学部、群馬県桐生市
    • Year and Date
      2007-07-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Synthesis and Properties of a Block Copolymer Composed of Elastin-like Polypeptide and Polyethylene glycol2007

    • Author(s)
      Aya Inoue, Hiroyuki Oku, Keiichi Yamada, et al.
    • Organizer
      The 2nd Gunma International Symposium on Chemistry (GIS2007)
    • Place of Presentation
      桐生市
    • Year and Date
      2007-07-21
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Synthesis and Thermo-responding Properties of Poly (Xaa-Ile-Gly-Lac-Pro) (Xaa=Ala and Gly, Lac=Lactic Acid Residue)2007

    • Author(s)
      Yuya Shimoda, Hiroyuki Oku, Keiichi Yamada, et al.
    • Organizer
      The 2nd Gunma International Symposium on Chemistry (GIS2007)
    • Place of Presentation
      桐生市
    • Year and Date
      2007-07-21
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 熱帯熱マラリア原虫由来の人工抗原を内包したナノ・マイクロ微粒子に関する研究2007

    • Author(s)
      神野恵治, 奥浩之, 茂木健司, 山口徹, 根岸明秀, 笹岡邦典, 狩野証夫
    • Organizer
      第61回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      神戸国際会議場、神戸市
    • Year and Date
      2007-04-19
    • Related Report
      2010 Final Research Report
  • [Presentation] 各種生体吸収性材料の生体内における物性変化ならびに組織為害性に関する検討-薬剤徐放化などに臨床応用-2007

    • Author(s)
      神野恵治, 奥浩之, 茂木健司, ら.
    • Organizer
      第61回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      神戸市
    • Year and Date
      2007-04-19
    • Related Report
      2009 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 微粒子およびその製造方法2009

    • Inventor(s)
      奥浩之, 俵義宣, 山田圭一, 片貝良一, 佐藤久美子, 鈴木守, 矢野和彦, 狩野繁之
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Filing Date
      2009-03-10
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 熱帯熱マラリア原虫蛋白質を内包したナノ・マイクロ微粒子の製造法2009

    • Inventor(s)
      奥浩之, 山田圭一, 狩野繁之, 他.
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Filing Date
      2009-03-10
    • Related Report
      2009 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 微粒子およびその製造方法2009

    • Inventor(s)
      奥浩之 他7名
    • Industrial Property Rights Holder
      群馬大学
    • Filing Date
      2009-03-12
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 微粒子およびその製造方法2008

    • Inventor(s)
      奥浩之, 俵義宣, 山田圭一, 片貝良一, 佐藤久美子, 鈴木守, 矢野和彦, 狩野繁之
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Filing Date
      2008-03-27
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 熱帯熱マラリア原虫蛋白質を内包したナノ・マイクロ微粒子の製造法2008

    • Inventor(s)
      奥浩之, 山田圭一, 狩野繁之, 他.
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Filing Date
      2008-03-27
    • Related Report
      2009 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 微粒子およびその製造方法2008

    • Inventor(s)
      奥浩之他8名
    • Industrial Property Rights Holder
      群馬大学
    • Filing Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 温度応答性配列を含むデプシペプチド構造と親水性高分子構造からなるブロック共重合体2007

    • Inventor(s)
      奥浩之, 井上彩, 下田裕也, 高山千恵, 小森谷真澄, 山田圭一, 片貝良一
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Filing Date
      2007-10-22
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] DEPSIPEPTIDE CONTAINING LACTIC ACID RESIDUE2007

    • Inventor(s)
      奥浩之, 俵義宣, 山田圭一, 片貝良一, 佐藤久美子, 鈴木守, 矢野和彦, 狩野繁之
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Filing Date
      2007-08-10
    • Related Report
      2010 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 両親媒性の高分子配位子によって安定化された高分子錯体および検査用組成物および医薬組成物2007

    • Inventor(s)
      奥浩之, 山田圭一, 片貝良一, 花岡宏史, 飯田靖彦, 織内昇, 遠藤啓吾, 早川晃一, 小濱一弘
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Filing Date
      2007-06-13
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 水油界面を利用した薬物-シリカ封入体の製造法2007

    • Inventor(s)
      奥浩之, 神野恵治, 茂木健司
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Filing Date
      2007-04-17
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 温度応答性配列を含むデプシペプチド構造と親水性高分子構造からなるブロック共重合体2007

    • Inventor(s)
      奥浩之, 山田圭一, 他.
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Filing Date
      2007-10-22
    • Related Report
      2009 Self-evaluation Report
  • [Patent(Industrial Property Rights)] DEPSIPEPTIDE CONTAINING LACTIC ACID RESIDUE2007

    • Inventor(s)
      Oku, H., Yamada, K., et al.
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Filing Date
      2007-08-10
    • Related Report
      2009 Self-evaluation Report

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Published: 2007-04-01   Modified: 2016-04-21  

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