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Study on discontinuous nonequilibrium mechanism in crystal nucleation and its application to production of nanocrystals

Research Project

Project/Area Number 19560758
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Properties in chemical engineering process/Transfer operation/Unit operation
Research InstitutionOsaka City University

Principal Investigator

OOSHIMA Hiroshd  Osaka City University, 大学院・工学研究科, 教授 (20112526)

Co-Investigator(Kenkyū-buntansha) 五十嵐 幸一  大阪市立大学, 大学院・工学研究科, 助教 (70315977)
Co-Investigator(Renkei-kenkyūsha) IGARASHI Koichi  大阪市立大学, 大学院・工学研究科, 助教 (70315977)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords核形成メカニズム / 粒径分布 / 結晶 / 晶析 / マイクロ波 / 溶液の熱履歴 / 核発生 / 微結晶 / 粒径と粒径分布 / 有機化合物の結晶 / マイクロ波照射 / 反復晶析 / 微結晶の晶析
Research Abstract

医薬化合物のナノ結晶製造を目指して、結晶核発生のメカニズムを解析するとともに、核発生のタイミングを揃えるための晶析操作について検討した。核発生のタイミングを制御する手法として、「熱履歴操作による核発生のタイミング制御」と「マイクロ波照射による核発生タイミング制御」を考案し、新しい晶析装置の開発を行った。そして、それらの手法が均一な微細結晶を製造するための手段として有効であることを明らかにした

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (31 results)

All 2009 2008 2007 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (20 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Effects of impurities on crystal polymorphism of an imidazopyridine derivative developed as a drug substance for osteoporosis2009

    • Author(s)
      K. Machiya, S. Ieda, M. Hirano, and H. Ooshima
    • Journal Title

      J.Chem.Eng.Japan 42

      Pages: 147-152

    • NAID

      10025305749

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between crystal polymorphism and solution structure of an imidazopyridine derivative as a drug substance for osteoporosis2009

    • Author(s)
      M. Hirano, K. Igarashi K. Machiya, R. Tamura, H. Tue, and H. Ooshima
    • Journal Title

      J. Chem. Eng. Japan 42

      Pages: 204-211

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of impurities on crystal polymorphism of an imidazopyridine derivative developed as a drug substance for osteoporosis2009

    • Author(s)
      K. Machiya, S. Ieda, M. Hirano, H. Ooshima
    • Journal Title

      J. Chem. Eng. Japan 42

      Pages: 147-152

    • NAID

      10025305749

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between crystal polymorphism and solution structure of an imidazopyridine derivative as a drug substance for osteoporosis2009

    • Author(s)
      M. Hirano, K. Igarashi, K. Machiya, R. Tamura, H. Tue, H. Ooshima
    • Journal Title

      J. Chem. Eng. Japan 42

      Pages: 204-211

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production of spherical agglomerates of cephalosporin antibiotic crystals2008

    • Author(s)
      K. Machiya, K. Koga, T. Mukuta, S. Moriki, K. Kagara, and H. Ooshima
    • Journal Title

      J. Chem. Eng. Japan 41

      Pages: 1017-1023

    • NAID

      10024448337

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth mechanism of the calcium carbonate tubes on a cation-exchange membrane2008

    • Author(s)
      K. Igarashi M. Takiguchi and H. Ooshima
    • Journal Title

      Journal of the Ceramic Society of Japan 116

      Pages: 111-114

    • NAID

      110006614254

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Production of spherical agglomerates of cephalosporin antibiotic crystals2008

    • Author(s)
      K. Machiya, K. Koga, T. Mukuta, S. Moriki, K. Kagara, H. Ooshima
    • Journal Title

      J. Chem. Eng. Japan 41

      Pages: 1017-1023

    • NAID

      10024448337

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth mechanism of the calcium carbonate tubes on a cation-exchange membrane2008

    • Author(s)
      K. Igarashi, M. Takiguchi and H. Ooshima
    • Journal Title

      Journal of the Ceramic Society of Japan 116

      Pages: 111-114

    • NAID

      110006614254

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 有機化合物BPPIの溶媒和物析出のメカニズム2009

    • Author(s)
      平野優、五十嵐幸一、大嶋寛
    • Organizer
      化学工学会第74年会
    • Place of Presentation
      横浜国立大学
    • Year and Date
      2009-03-18
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 有機化合物BPPIの溶媒和物析出に及ぼすメタノール-IPA混合溶媒組成の影響2008

    • Author(s)
      平野優、五十嵐幸一、大嶋寛
    • Organizer
      化学工学会姫路大会
    • Place of Presentation
      ホテル日航姫略
    • Year and Date
      2008-11-18
    • Related Report
      2008 Final Research Report
  • [Presentation] 有機化合物BPPIの溶媒和物析出に及ぼすメタノール-IPA混合溶媒組成の影響2008

    • Author(s)
      平野 優, 五十嵐 幸一, 大嶋 寛
    • Organizer
      化学工学会姫路大会
    • Place of Presentation
      ホテル日航姫路
    • Year and Date
      2008-11-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 結晶の完全な再溶解を組み込んだ晶析操作2008

    • Author(s)
      五十嵐幸一、盛岡あゆみ、山口良太、大嶋寛
    • Organizer
      化学工学会第40回秋季大会
    • Place of Presentation
      東北大学
    • Year and Date
      2008-09-25
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 超高速攪拌mL-スケール連続晶析装置により得られた有機化合物結晶の形状2008

    • Author(s)
      久保直毅、五十嵐幸一、大嶋寛
    • Organizer
      化学工学会第73回年会
    • Place of Presentation
      静岡大学、浜松
    • Year and Date
      2008-03-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 超高速撹拌mL-スケール連続晶析装置により得られた有機化合物結晶の形状2008

    • Author(s)
      久保 直毅、五十嵐 幸一、大嶋 寛
    • Organizer
      化学工学会第73回年会
    • Place of Presentation
      静岡大学、浜松
    • Year and Date
      2008-03-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] Control of Nucleation by Microwave Irradiation in Cooling Crystallization and Its Effects on Characteristics of Crystals2008

    • Author(s)
      Y. Nishitani, K. Igarashi, H. Ooshima
    • Organizer
      8th International Conference on Separation Science and Technology
    • Place of Presentation
      Karuizawa, Nagano Japan
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Drawning-out Crystallization of Organic Compounds Using A ML-Scale Crystallizer2008

    • Author(s)
      K. Igarashi, N. Kubo, Y. Yamanaka and H. Ooshima
    • Organizer
      8th International Conference on Separation Science and Technology
    • Place of Presentation
      Karuizawa, Nagano Janan
    • Related Report
      2008 Final Research Report
  • [Presentation] Understandings of precipitation Behavior of crystal polymorphs and solvent-mediated transformation2008

    • Author(s)
      H. Ooshima, M. Hirano, and K. Igarashi
    • Organizer
      17th International Symposium on Industrial Crystallization
    • Place of Presentation
      Maarstricht, the Netherlands
    • Related Report
      2008 Final Research Report
  • [Presentation] Understandings of precipitation bBehavior of crystal polymorphs and solvent-mediated transformation2008

    • Author(s)
      H. Ooshima, M. Hirano, K. Igarashi
    • Organizer
      17th International Symposium on Industrial Crystallization
    • Place of Presentation
      Maarstricht, the Netherlands
    • Related Report
      2008 Annual Research Report
  • [Presentation] Drawing-out Crystallization of Organic Compounds Using A ML-Scale Crystallizer2008

    • Author(s)
      K. Igarashi, N. Kubo, Y. Yamanaka, H. Ooshima
    • Organizer
      8th International Conference on Separation Science and Technology
    • Place of Presentation
      Karuizawa, Nagano Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] [展望講演]結晶多形・擬多形を制御するための考え方と課題2007

    • Author(s)
      大嶋寛
    • Organizer
      化学工学会第39回秋季大会
    • Place of Presentation
      北海道大学、札幌
    • Year and Date
      2007-09-15
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] t-ブトキシカルボニル-L-アスパラギン(BocASN)の結晶形状に及ぼす溶媒の影響2007

    • Author(s)
      平野優、五十嵐幸一、大嶋寛
    • Organizer
      化学工学会第39回秋季大会
    • Place of Presentation
      北海道大学、札幌
    • Year and Date
      2007-09-14
    • Related Report
      2008 Final Research Report
  • [Presentation] t-ブトキシカルボニルーL-アスパラギン(BocASN)の結晶形状に及ぼす溶媒の影響2007

    • Author(s)
      平野 優、五十嵐 幸一、大嶋 寛
    • Organizer
      化学工学会第39回秋季大会
    • Place of Presentation
      北海道大学、札幌
    • Year and Date
      2007-09-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] L-アラニンの核発生挙動2007

    • Author(s)
      竹内千尋、五十嵐幸一、大嶋寛
    • Organizer
      化学工学会第39回秋季大会
    • Place of Presentation
      北海道大学、札幌
    • Year and Date
      2007-09-13
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] [優秀論文賞]水難溶性溶媒を用いて得られる水和物擬多形結晶とそれを大量生産するための連続晶析操作2007

    • Author(s)
      河内秀夫、太嶋寛
    • Organizer
      化学工学会第39回秋季大会
    • Place of Presentation
      北海道大学、札幌
    • Year and Date
      2007-09-13
    • Related Report
      2008 Final Research Report
  • [Presentation] [優秀論文賞」水難溶性溶媒を用いて得られる水和物擬多形結晶とそれを大量生産するための連続晶析操作2007

    • Author(s)
      河内 秀夫、大嶋 寛
    • Organizer
      化学工学会第39回秋季大会
    • Place of Presentation
      北海道大学、札幌
    • Year and Date
      2007-09-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] [Invited Lecture]Control of Crystal Polymorphism of Organic Compound2007

    • Author(s)
      H.Ooshima
    • Organizer
      Symposium of Industrial Crystallization in Kyung Hee University
    • Place of Presentation
      Kyung Hee University, Korea
    • Year and Date
      2007-06-10
    • Related Report
      2008 Final Research Report
  • [Presentation] [Invited Lecture]Control of Crystal Polymorphism of Organic Compound2007

    • Author(s)
      H.Ooshima
    • Organizer
      Symposium of Industrial Crystallization in Kyung Hee University
    • Place of Presentation
      Kyung Hee University,Korea
    • Year and Date
      2007-06-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] イブプロフェンの結晶化に及ぼすマイクロ波照射の影響2007

    • Author(s)
      西谷祐介、五十嵐幸一、大嶋寛
    • Organizer
      分離技術会年会2007
    • Place of Presentation
      名古屋工業大学、名古屋
    • Year and Date
      2007-06-07
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Book] ファインケミカルシリーズ医薬品原薬・中間体製造におけるスケールアップとトラブル対策2008

    • Author(s)
      橋本光紀監修、大嶋寛ら21名
    • Publisher
      シーエムシー出版
    • Related Report
      2008 Final Research Report
  • [Book] ファインケミカルシリーズ 医薬品原薬・中間体製造におけるスケールアップとトラブル対策2008

    • Author(s)
      橋本光紀 監修, 大嶋寛ら21名
    • Total Pages
      267
    • Publisher
      シーエムシー出版
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.bioa.eng.osaka-cu.ac.jp/Bioengineering/TOP.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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