Elucidation of the molecular evolution of the major histocompatibility complex (MHC) molecule, critical for the defense system of the jawed vertebrates
| Project/Area Number |
19570223
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Evolutionary biology
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| Research Institution | Fujita Health University |
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Principal Investigator |
HASHIMOTO Keiichiro Fujita Health University, 総合医科学研究所, 教授 (70192268)
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| Co-Investigator(Kenkyū-buntansha) |
DIJKSTRA J・M 藤田保健衛生大学, 総合医科学研究所, 助教 (10387681)
山口 央輝 藤田保健衛生大学, 総合医科学研究所, 助教 (70319250)
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| Co-Investigator(Renkei-kenkyūsha) |
DIJKSTRA J・M 藤田保健衛生大学, 総合医科学研究所, 助教 (10387681)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 免疫 / 分子進化 / 生体防御 / 魚類 / 遺伝子 / MHC / 獲得免疫系 / 有顎脊椎動物 / 進化 / ゲノム / 生体分子 / 免疫学 / 主要組織適合遺伝子複合体 |
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| Research Abstract |
To elucidate the evolution of MHC molecules in the vertebrates, we tried to isolate novel MHC-related genes from various fish genome. Fish is the critical and the most primitive animal group in which the MHC-related genes could be found. We investigated MHC-related genes in the fish genome and also transcripts of those genes using RACE method. We also found some genes in the fish which can encode proteins with some MHC-related domains.
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Report
(6 results)
Research Products
(30 results)
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[Journal Article] A molecule in teleost fish, related with human MHC-encoded G6F, has a cytoplasmic tail with ITAM and marks the surface of thrombocytes and in some fishes also of erythrocytes.2010
Author(s)
Ohashi K, Takizawa F, Tokumaru N, Nakayasu C, Toda H, Fischer U, Moritomo T, Hashimoto K, Nakanishi T, Dijkstra JM.
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Journal Title
Immunogenetics 62
Pages: 543-559
Related Report
Peer Reviewed
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