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Response mechanism of anti-oxidant enzymes with bacterial infection in fishes-Cell biological approach -

Research Project

Project/Area Number 19580236
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Fisheries chemistry
Research InstitutionNagasaki University

Principal Investigator

OSATOMI Kiyoshi  Nagasaki University, 水産学部, 教授 (40253702)

Co-Investigator(Kenkyū-buntansha) ODA Tatsuya  長崎大学, 水産学部, 教授 (60145307)
HARA Kenji  長崎大学, 水産学部, 教授 (10039737)
TACHIBANA Katsuyasu  長崎大学, 水産学部, 教授 (20171712)
KANAI Kinya  長崎大学, 水産学部, 教授 (40145222)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords抗酸化酵素 / 活性酸素 / 魚病細菌 / 酸化ストレス / 細胞培養系 / 培養細胞系 / クローニング / 遺伝子構造
Research Abstract

In this study, we demonstrated that high virulent strain (NUF251) of Edwardsiella tarda has an ability to prevent the production of reactive oxygen species (ROS) by macrophages, and is even capable of surviving and multiplying within Japanese flounder peritoneal macrophages, where the low virulent strain (NUF194) has no ability.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (8 results)

All 2010 2009 2008 2007

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results)

  • [Journal Article] Comparative analysis of the production of nitric oxide (NO) and tumor necrosis factor-α(TNF-α) from macrophages exposed to high virulent and low virulent strains of Edwardsiella tarda.2009

    • Author(s)
      K. Ishibe, T. Yamanishi, Y. Wang, K. Osatomi, K. Hara, K. Kanai, K. Yamaguchi, T. Oda
    • Journal Title

      Fish&Shellfish Immunology Vol.27

      Pages: 386-389

    • NAID

      120006984058

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the responses of peritoneal macrophages from Japanese flounder (Paralichthys olivaceus) against high virulent and low virulent strains of Edwardsiella tarda.2008

    • Author(s)
      K. Ishibe, K. Osatomi, K. Hara, K. Kanai, K. Yamaguchi, T. Oda
    • Journal Title

      Fish&Shellfish Immunology Vol.24

      Pages: 243-251

    • NAID

      120006983895

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the responses of peritoneal macrophages from Japanese flounder (Paralichthys olivaceus) against high virulent and low virulent strains of Edwardsiella tarda2008

    • Author(s)
      Keiko Ishibe
    • Journal Title

      Fish & Shellfish Immunology 24

      Pages: 243-251

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Edwardsiella tarda暴露に伴うマクロファージ系細胞株のNO産生及びiNOSの応答2010

    • Author(s)
      王亜軍
    • Organizer
      2010年度日本水産学会春季大会
    • Place of Presentation
      日本大学生物資源科学部
    • Year and Date
      2010-03-27
    • Related Report
      2009 Final Research Report
  • [Presentation] Edwardsiella tarda暴露に伴うマクロファージ系細胞株のNO産生及びiNOSの応答2010

    • Author(s)
      王亜軍
    • Organizer
      2010年度 日本水産学会春季大会
    • Place of Presentation
      日本大学生物資源科学部
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Edwardsiella tarda (E. tarda)暴露に伴うヒラメ腹腔マクロファージによる活性酸素種とNOの産生2009

    • Author(s)
      王亜軍
    • Organizer
      2009年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学(品川キャンパス)
    • Year and Date
      2009-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] Edwardsiella tarda(E. tarda)暴露に伴うヒラメ腹腔マクロファージによる活性酸素種とNOの産生2009

    • Author(s)
      王 亜軍
    • Organizer
      2009年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学(品川キャンパス)
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 魚病細菌感染による培養細胞の活性酸素産生能及びSODの応答2007

    • Author(s)
      石部恵子
    • Organizer
      2007年度日本水産学会秋季大会
    • Place of Presentation
      北海道大学水産学部
    • Year and Date
      2007-09-26
    • Related Report
      2009 Final Research Report 2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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