Mechanism for control of gastrointestinal motility by a novel peptides released from the stomach.

• Project/Area Number: 19580337
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Gifu University
• Principal Investigator: SHIMIZU Yasutake Gifu University, 応用生物科学部, 教授 (40243802)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: グレリン / デスアシルグレリン / 消化管運動 / 排便中枢 / 骨盤神経 / 過敏性腸症候群 / 脊髄 / オベスタチン

Research Abstract

最近、食欲を変化させるグレリンと呼ばれるホルモンが胃から分泌されることが発見された。この研究の目的は、グレリンに消化管の運動を調節する作用があるか明らかにすることである。ラットを用いた実験から、グレリンは胃だけではなく脊髄の中でも作られていて、脊髄で作られるグレリンが自律神経を活発にして、大腸の運動を強くすることがわかった。ストレスによる下痢や便秘を改善するために応用可能な現象であると考えられる。

Research Products

• [Journal Article] Functional and in situ hybridisation evidence that preganglionic sympathetic vasoconstrictor neurons express ghrelin receptors. (2010)
  • Author(s): Ferens, D.M., Yin, L., Bron, R., Hunne, B., Ohashi-Doi, K., Kitchener, P.D., Sanger, G.J., Witherington, J., Shimizu, Y., Furness, J.B.
  • Journal Title: Neuroscience Vol.166 Pages: 671-679
  • Peer Reviewed
• [Journal Article] Contractile properties of esophageal striated muscle: comparison with cardiac and skeletal muscles in rats. (2010)
  • Author(s): Shiina, T., Shima, T., Masuda, K., Hirayama, H., Iwami, M., Takewaki, T., Kuramoto, H., Shimizu, Y.
  • Journal Title: J. Biomed. Biotech. Vol.2010 Pages: 7-7
  • Peer Reviewed
• [Journal Article] Contractile responses induced by physalaemin, an analogue of substance P, in the rat esophagus. (2010)
  • Author(s): Shiina, T., Shima, T., Hirayama, H., Kuramoto, H., Takewaki, T., Shimizu, Y.
  • Journal Title: Eur. J. Pharmacol. Vol.628 Pages: 202-206
  • Peer Reviewed
• [Journal Article] The neural regulation of the mammalian esophageal motility and its implication for esophageal diseases. (2010)
  • Author(s): Shiina, T., Shima, T., Worl, J., Neuhuber, W.L., Shimizu, Y.
  • Journal Title: Pathophysiology Vol.17 Pages: 129-133
  • Peer Reviewed
• [Journal Article] Functional and in situ hybridisation evidence that preganglionic sympathetic vasoconstrictor neurons express ghrelin receptors. (2010)
  • Author(s): Ferens, D.M., et.al.
  • Journal Title: Neuroscience 166 Pages: 671-679
  • Peer Reviewed
• [Journal Article] Contractile properties of esophageal striated muscle : comparison with cardiac and skeletal muscles in rats. (2010)
  • Author(s): Shiina, T., et.al.
  • Journal Title: J.Biomed.Biotech. (印刷中)
  • Peer Reviewed
• [Journal Article] Contractile responses induced by physalaemin, an analogue of substance P, in the rat esophagus. (2010)
  • Author(s): Shiina, T., et.al.
  • Journal Title: Eur.J.Pharmacol. 628 Pages: 202-206
  • Peer Reviewed
• [Journal Article] The neural regulation of the mamalian esophageal motility and its implication for esophageal diseases. (Review) (2010)
  • Author(s): Shiina, T., et.al.
  • Journal Title: Pathophysiology 17 Pages: 129-133
  • Peer Reviewed
• [Journal Article] Capsaicin inhibits IFN-gamma-induced MHC class II expression by suppressing transcription of class II transactivator gene in murine peritoneal macrophages. (2010)
  • Author(s): Mahmoud, M.E., et.al.
  • Journal Title: Int.Immunopharmacol. 10 Pages: 86-90
  • Peer Reviewed
• [Journal Article] Oral administration of a centrally-acting ghrelin receptor agonist to conscious rats triggers defecation. (2009)
  • Author(s): Shafton, A.D., Sanger, G.J., Witherington, J., Brown, J.D., Muir, A., Butler, S., Abberley, L., Shimizu, Y., Furness, J.B.
  • Journal Title: Neurogastroenterol. Motil. Vol.21 Pages: 71-77
  • Peer Reviewed
• [Journal Article] Neuhuber WL Galanin modulates vagally induced contractions in the mouse esophagus. (2009)
  • Author(s): Boudaka A, Worl J, Shiina T, Shimizu Y, Takewaki T.
  • Journal Title: Neurogastroenterol. Motil. Vol.21 Pages: 180-188
  • Peer Reviewed
• [Journal Article] P2X purinoceptors mediate an endothelium-dependent hyperpolarization in longitudinal smooth muscle of anterior mesenteric artery in young chickens. (2009)
  • Author(s): Alkayed, F., et.al.
  • Journal Title: Br.J.Phramacol. 158 Pages: 888-895
  • Peer Reviewed
• [Journal Article] Activation of murine macrophages by the extract from Calotropis procera latex. (2009)
  • Author(s): Seddek, A.l.S., et.al.
  • Journal Title: J.Nat.Med. 63 Pages: 297-303
  • Peer Reviewed
• [Journal Article] Oral administration of a centrally-acting ghrelin receptor agonist to conscious rats triggers defecation. (2009)
  • Author(s): Shafton, A. D.
  • Journal Title: Neurogastroenterol. Motil. 21 Pages: 71-77
  • Peer Reviewed
• [Journal Article] Galanin modulates vagally induced contractions in the mouse esophagus. (2009)
  • Author(s): Boudaka, A.
  • Journal Title: Neurogastroenterol. Motil. 21 Pages: 180-188
  • Peer Reviewed
• [Journal Article] Extension of time until cardiac arrest after injection of a lethal dose of pentobarbital in the hibernating Syrian hamster. (2009)
  • Author(s): Miyazawa, S.
  • Journal Title: J. Vet. Med. Sci. 71 Pages: 383-385
  • Peer Reviewed
• [Journal Article] Tachykinins and their functions in the gastrointestinal tract. (2008)
  • Author(s): Shimizu, Y., Matsuyama, H., Shiina, T., Takewaki, T., Furness, J. B
  • Journal Title: Cell. Mol. Life Sci. Vol.65 Pages: 295-311
  • Peer Reviewed
• [Journal Article] Central A1-receptor activation associated with onset of torpor protects the heart against low temperature in the Syrian hamster. (2008)
  • Author(s): Miyazawa, S.
  • Journal Title: Am. J. Physiol. 295
  • Peer Reviewed
• [Journal Article] Relationship between taste-induced physiological reflexes and temperature of sweet taste. (2008)
  • Author(s): Shinozaki, K.
  • Journal Title: Physiol. Behav. 93 Pages: 1000-1004
  • Peer Reviewed
• [Journal Article] Capsaicin pretreatment attenuates LPS-induced hypothermia through TRP V1-independent mechanisms in chicken. (2008)
  • Author(s): Nikami, H.
  • Journal Title: Life Sci. 82 Pages: 1191-1195
  • Peer Reviewed
• [Journal Article] Tachykinins and their functions in the gastrointestinal tracts. (2008)
  • Author(s): Shimizu, Y
  • Journal Title: Cell. Mol. Life Sci. 65 Pages: 295-311
  • Peer Reviewed
• [Journal Article] Effects of NMDA receptor antagonists on visceromotor reflexes and on intestinal motility (2007)
  • Author(s): Shafton AD, Bogeski G, Kitchener P, Sanger GJ, Furness JB, Shimizu Y
  • Journal Title: in vivo. Neurogastroenterol. Motil. Vol.19 Pages: 617-624
  • Peer Reviewed
• [Journal Article] Involvement of TRPV1-dependent and-independent components in the regulation of vagally induced contractions in the mouse esophagus. (2007)
  • Author(s): Boudaka A, Worl J, Shiina T, Neuhuber WL, Kobayashi H, Shimizu Y, Takewaki T
  • Journal Title: Eur J Pharmacol. Vol.556 Pages: 157-165
  • NAID: 120006340935
  • Peer Reviewed
• [Journal Article] Impairment and restoration of spontaneous contractile activity of longitudinal smooth muscles in the TNBS-inflamed hamster distal colon. (2007)
  • Author(s): Gurung, Y.B., Shimizu, Y., Shiina, T., Mahmoud, M.E., Saito, S., Takewaki, T.
  • Journal Title: Biomed. Res. Vol.28 Pages: 301-308
  • NAID: 130004470691
  • Peer Reviewed
• [Journal Article] Key role of mucosal primary afferents in mediating the inhibitory influence of capsaicin on vagally mediated contractions in the mouse esophagus. (2007)
  • Author(s): Boudaka A, Worl J, Shiina T, Saito S, Atoji Y, Kobayashi H, Shimizu Y, Takewaki T
  • Journal Title: J Vet Med Sci. Vol.69 Pages: 365-372
  • NAID: 110006250076
  • Peer Reviewed
• [Journal Article] Purinergic control of the quail rectum: Modulation of adenosine 5'-triphosphate-mediated contrac-tion with acetylcholine. (2007)
  • Author(s): Shiina T, El-Mahmoudy A, Khalifa M, Draid M, Shimizu Y, Takewaki T
  • Journal Title: Res. Vet. Sci. Vol.82 Pages: 246-251
  • Peer Reviewed
• [Journal Article] Impairment and restoration of spontaneous contractile activity or longitudinal smooth muscles in the TNBS-inflamed hamster distal colon. (2007)
  • Author(s): Gurung, Y. B.
  • Journal Title: Biomed. Res. 28 Pages: 301-308
  • Peer Reviewed
• [Journal Article] Involvement of TRPVl-dependent and-independent components in the regulation of vagally induced contractions in the mouse esophagus. (2007)
  • Author(s): Boudaka, A.
  • Journal Title: Eur. J. Pharmacol. 556 Pages: 157-165
  • Peer Reviewed
• [Presentation] in vivoの実験系を用いた消化管運動の解析:グレリンの脊髄排便中枢を介する大腸運動促進作用 (2010)
  • Author(s): 志水泰武, 平山晴子, 嶋剛士, 椎名貴彦
  • Organizer: 第149回日本獣医学会
  • Place of Presentation: 武蔵野
  • Year and Date: 2010-03-27
• [Presentation] ラット食道横紋筋の収縮特性および内在神経系による運動調節機構 (2010)
  • Author(s): 椎名貴彦, 武脇義, 志水泰武
  • Organizer: 第149回日本獣医学会
  • Place of Presentation: 武蔵野
  • Year and Date: 2010-03-27
• [Presentation] in vivoの実験系を用いた消化管運動の解析:グレリンの脊髄排便中枢を介する大陽運動促進作用 (2010)
  • Author(s): 志水泰武, 他
  • Organizer: 第149回日本獣医学会学術集会
  • Place of Presentation: 武蔵野
  • Year and Date: 2010-03-26
• [Presentation] ラット食道横紋筋の収縮特性および内在神経系による運動調節機構 (2010)
  • Author(s): 椎名貴彦, 他
  • Organizer: 第149回日本獣医学会学術集会
  • Place of Presentation: 武蔵野
  • Year and Date: 2010-03-26
• [Presentation] スンクス食道の形態学的および薬理学的特徴 (2010)
  • Author(s): 椎名貴彦, 他
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-18
• [Presentation] 消化器疾患に関する生理学的アプローチ(招待講演) (2010)
  • Author(s): 志水泰武
  • Organizer: 第1回中部症例検討会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-02-10
• [Presentation] 嘔叶する小型実験動物スンクスの食道筋構造と神経支配 (2010)
  • Author(s): 椎名貴彦, 他
  • Organizer: 第20回日本病態生理学会
  • Place of Presentation: 奈良
  • Year and Date: 2010-01-24
• [Presentation] カプサイシン感受性神経を介するラット食道蠕動の制御 (2010)
  • Author(s): 嶋剛士, 他
  • Organizer: 第20回日本病態生理学会
  • Place of Presentation: 奈良
  • Year and Date: 2010-01-24
• [Presentation] グレリン、デスアシルグレリンおよびオベスタチンがラット大陽運動に及ぼす影響 (2010)
  • Author(s): 平山晴子, 他
  • Organizer: 第20回日本病態生理学会
  • Place of Presentation: 奈良
  • Year and Date: 2010-01-24
• [Presentation] ラット大陽運動に対するショウガ辛味成分Zingeroneの抑制作用 (2010)
  • Author(s): 石見百江, 他
  • Organizer: 第20回日本病態生理学会
  • Place of Presentation: 奈良
  • Year and Date: 2010-01-24
• [Presentation] グレリン、デスアシルグレリンおよびオベスタチンがラット大腸運動に及ぼす影響 (2010)
  • Author(s): 平山晴子, 椎名貴彦, 志水泰武
  • Organizer: 第20回病態生理学会
  • Place of Presentation: 奈良
  • Year and Date: 2010-01-23
• [Presentation] 消化管の成り立ちと機能 下痢の病態(招待講演) (2009)
  • Author(s): 志水泰武
  • Organizer: 第7回臨床獣医学A to Z
  • Place of Presentation: 名古屋
  • Year and Date: 2009-12-22
• [Presentation] The role of ghrelin, des-acyl ghrelin and obestatin in the regulation system of colorectal motility in rats. (2009)
  • Author(s): Haruko Hirayama, Takehiko Toda, Takahiko Shiina, Hirofumi Kuramoto, Tadashi Takewaki, John B Furness, Yasutake Shimizu
  • Organizer: 2009 International Symposium on Ghrelin
  • Place of Presentation: 東京
  • Year and Date: 2009-11-19
• [Presentation] The role of ghrelin, des-acyl ghrelin and obestatin in the regulation system of colorectal motility in rats (2009)
  • Author(s): Hirayama, H, et.al.
  • Organizer: 2009 International Symposium on Ghrelin
  • Place of Presentation: 東京
  • Year and Date: 2009-11-18
• [Presentation] 冬眠時の心拍動を維持するメカニズム(招待講演) (2009)
  • Author(s): 志水泰武, 他
  • Organizer: 第55回日本宇宙航空環境医学会大会
  • Place of Presentation: 岐阜
  • Year and Date: 2009-11-13
• [Presentation] グレリンによるラット大腸運動促進効果に対するデスアシルグレリンおよびオベスタチンの拮抗作用 (2009)
  • Author(s): 平山晴子, 戸田壮彦, 椎名貴彦, 藏本博史, 志水泰武
  • Organizer: 第148回獣医学会
  • Place of Presentation: 鳥取
  • Year and Date: 2009-09-26
• [Presentation] TRPV1はマウス大腸炎に伴う消化管運動の低下に関与する (2009)
  • Author(s): 山川友佳, 椎名貴彦, 志水泰武
  • Organizer: 第148回獣医学会
  • Place of Presentation: 鳥取
  • Year and Date: 2009-09-26
• [Presentation] 出生直後の未発達な神経支配を補完するめのラット食道横紋筋の特性 (2009)
  • Author(s): 中森智昭, 他
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: 鳥取
  • Year and Date: 2009-09-26
• [Presentation] スンクス(Suncus murinus)食道運動における神経性制御 (2009)
  • Author(s): 椎名貴彦, 他
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: 鳥取
  • Year and Date: 2009-09-26
• [Presentation] グレリンによるラット大陽運動促進効果に対するデスアシルグレリンおよびオベスタチンの拮抗作用 (2009)
  • Author(s): 平山晴子, 他
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: 鳥取
  • Year and Date: 2009-09-26
• [Presentation] TRPV1はマウス大腸炎に伴う消化管運動の低下に関与する (2009)
  • Author(s): 山川友佳, 他
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: 鳥取
  • Year and Date: 2009-09-26
• [Presentation] Grain of paradise extracts and its active principal component 6-paradol activate the sympathetic nerve activity brown adipose tissue in rats (2009)
  • Author(s): Shimizu, Y, et.al.
  • Organizer: ISAN2009(国際自律神経学会)
  • Place of Presentation: シドニー(オーストラリア)
  • Year and Date: 2009-09-04
• [Presentation] Roles of a capsaicin-sensitive neural circuit in peristaltic motility of the ratesophagus (2009)
  • Author(s): Shima, T, et al.
  • Organizer: ISAN2009(国際自律神経学会)
  • Place of Presentation: シドニー(オーストラリア)
  • Year and Date: 2009-09-04
• [Presentation] Neuronal regulation of the esophageal motility in Suncus murinus (a house musk shrew) (2009)
  • Author(s): Shiina, T, et al.
  • Organizer: ISAN2009(国際自律神経学会)
  • Place of Presentation: シドニー(オーストラリア)
  • Year and Date: 2009-09-04
• [Presentation] Antagonistic effects of des-acyl ghrelin and obestatin on ghrelin-induced enhancement of colorectal motility at the lumbo-sacral defecation center in rats (2009)
  • Author(s): Hirayama, H, et.al.
  • Organizer: ISAN2009(国際自律神経学会)
  • Place of Presentation: シドニー(オーストラリア)
  • Year and Date: 2009-09-04
• [Presentation] Effects of activation of ghrelin receptors in the spinal cord on cardiovascular function in the rat (2009)
  • Author(s): Bron, R, et.al.
  • Organizer: ISAN2009(国際自律神経学会)
  • Place of Presentation: シドニー(オーストラリア)
  • Year and Date: 2009-09-04
• [Presentation] Antagonistic effects of des-acyl ghrelin and obestatin on ghrelin-induced enhancement of colorectal motility at the lumbo-sacral defecation center in rats. (2009)
  • Author(s): H. Hirayama, T. Toda, T. Shiina, H. Kuramoto, T. Takewaki, J.B. Furness, Y. Shimizu
  • Organizer: 国際自律神経学会
  • Place of Presentation: ISAN2009:シドニー
  • Year and Date: 2009-09-03
• [Presentation] Neuronal regulation of the esophageal motility in Suncus murinus (a house musk shrew). (2009)
  • Author(s): T. Shiina, J. Worl, W.L. Neuhuber, T. Shima, T. Takewaki, Y. Shimizu
  • Organizer: 国際自律神経学会
  • Place of Presentation: ISAN2009:シドニー
  • Year and Date: 2009-09-03
• [Presentation] Roles of a capsaicin-sensitive neural circuit in peristaltic motility of the rat esophagus. (2009)
  • Author(s): T. Shima, T. Shiina, Y. Shimizu
  • Organizer: 国際自律神経学会
  • Place of Presentation: ISAN2009:シドニー
  • Year and Date: 2009-09-03
• [Presentation] Enhancement of colorectal motility by ghrelin, but not des-acyl ghrelin, through an activation of lumbo-sacral defecation centre in rats (2009)
  • Author(s): Shimizu, Y, et.al.
  • Organizer: ISAN2009(国際自律神経学会)
  • Place of Presentation: 京都
  • Year and Date: 2009-07-30
• [Presentation] Modulatory actions of tachykinins on the striated and smooth muscle motility in the rat esophagus (2009)
  • Author(s): Shiina, T, et al.
  • Organizer: IUPS2009(国際生理学会)
  • Place of Presentation: 京都
  • Year and Date: 2009-07-30
• [Presentation] Galanin modulates vagally induced contractions in the mouse esophagus (2009)
  • Author(s): Boudaka, A, et al.
  • Organizer: IUPS2009(国際生理学会)
  • Place of Presentation: 京都
  • Year and Date: 2009-07-30
• [Presentation] Enhancement of colorectal motility by ghrelin, but not des-acyl ghrelin, through an activation of lumbo-sacral defecation center in rats. (2009)
  • Author(s): Y Shimizu, H Hirayama, T Shiina, JB Furness, T Takewaki
  • Organizer: 国際生理学会
  • Place of Presentation: 京都
  • Year and Date: 2009-07-29
• [Presentation] Modulatory actions of tachykinins on the striated and smooth muscle motility in the rat esophagus. (2009)
  • Author(s): T Shiina, T Shima, H Hirayama, A Boudaka, J Woerl, WL Neuhuber, T Takewaki, Y Shimizu
  • Organizer: 国際生理学会
  • Place of Presentation: 京都
  • Year and Date: 2009-07-29
• [Presentation] アシル化グレリンおよびデスアシルグレリンのラット大腸運動に対する作用 (2009)
  • Author(s): 平山晴子, 椎名貴彦, 志水泰武
  • Organizer: 第51回日本平滑筋学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-22
• [Presentation] アシル化グレリンおよびデスアシルグレリンのラット大陽運動に対する作用 (2009)
  • Author(s): 平山晴子, 他
  • Organizer: 第51回日本平滑筋学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-22
• [Presentation] ラット食道蠕動運動におけるカプサイシン感受性神経の役割 (2009)
  • Author(s): 嶋剛士, 他
  • Organizer: 第51回日本平滑筋学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-22
• [Presentation] 新生仔ラット食道筋の収縮制御機構 (2009)
  • Author(s): 中森智昭, 他
  • Organizer: 第51回日本平滑筋学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-22
• [Presentation] プリン作動性神経によるニワトリ前腸間膜動脈縦走平滑筋の抑制性調節 (2009)
  • Author(s): Alkayed, F., 他
  • Organizer: 第51回日本平滑筋学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-22
• [Presentation] Efftcts of Grain of paradise extracts on the sympathetic nerve activity and uncoupling protein expression in brown adipose tissue (2009)
  • Author(s): Shimizu, Y
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-17
• [Presentation] Calotropis procera抽出物によって誘導されるマクロファージの活性化 (2009)
  • Author(s): 椎名貴彦
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-17
• [Presentation] 低体温によって惹起される障害を回避するメカニズム : 冬眠動物をモデルとした解析(ミニシンポジウム演題) (2009)
  • Author(s): 志水泰武
  • Organizer: 第19回日本病態生理学会
  • Place of Presentation: 所沢
  • Year and Date: 2009-01-24
• [Presentation] ラット食道運動におけるカプサイシン感受性神経の役割 (2009)
  • Author(s): 椎名貴彦
  • Organizer: 第19回日本病態生理学会
  • Place of Presentation: 所沢
  • Year and Date: 2009-01-24
• [Presentation] 脊髄排便中枢を介するグレリンの結直腸運動促進作用 (2008)
  • Author(s): 平山晴子, 椎名貴彦, 武脇義, 志水泰武
  • Organizer: 第55回中部日本生理学会
  • Place of Presentation: 愛知
  • Year and Date: 2008-10-17
• [Presentation] 脊髄排便中枢を介するグレリンの結直腸運動促進作用 (2008)
  • Author(s): 志水泰武
  • Organizer: 第55回中部日本生理学会
  • Place of Presentation: 愛知・長久手
  • Year and Date: 2008-10-17
• [Presentation] ラット食道粘膜筋板平滑筋の収縮を制御する神経伝達物質 (2008)
  • Author(s): 椎名貴彦
  • Organizer: 第55回中部日本生理学会
  • Place of Presentation: 愛知・長久手
  • Year and Date: 2008-10-17
• [Presentation] 幼若ニワトリ前腸間膜動脈縦走平滑筋に対するプリン作動性神経支配 (2008)
  • Author(s): Alkayed Feras
  • Organizer: 第146回日本獣医学会学術集会
  • Place of Presentation: 宮崎
  • Year and Date: 2008-09-25
• [Presentation] 新生子ラットの食道横紋筋および平滑筋に対する迷走神経支配 (2008)
  • Author(s): 中森智昭
  • Organizer: 第146回日本獣医学会学術集会
  • Place of Presentation: 宮崎
  • Year and Date: 2008-09-25
• [Presentation] カプサイシン感受性神経によるラット食道蠕動運動の制御 (2008)
  • Author(s): 嶋剛士
  • Organizer: 第146回日本獣医学会学術集会
  • Place of Presentation: 宮崎
  • Year and Date: 2008-09-25
• [Presentation] 冬眠動物の低体温に対する抵抗性は脳内アデノシン系により賦活化される (2008)
  • Author(s): 宮澤誠司
  • Organizer: 平成20年度体温調節、温度受容研究会
  • Place of Presentation: 岡崎
  • Year and Date: 2008-09-19
• [Presentation] グレリンの排便促進作用-アシル化グレリンおよびデスアシルグレリンを用いた検討- (2008)
  • Author(s): 平山晴子
  • Organizer: 第7回生体機能研究会
  • Place of Presentation: 箱根
  • Year and Date: 2008-08-09
• [Presentation] 冬眠導入時の脳内アデノシン系の賦活化は極度の低体温下での心拍動維持に寄与する (2008)
  • Author(s): 志水泰武
  • Organizer: 第7回生体機能研究会
  • Place of Presentation: 箱根
  • Year and Date: 2008-08-09
• [Presentation] Acylated ghrelin, but not des-acyl ghrelin, enhances colorectal motility by activating lumbo-sacral defecation center in rats. (2008)
  • Author(s): Shimizu Y, Hirayama H, Shiina T, Furness JB, Takewaki T
  • Organizer: 第81回薬理学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-02-18
• [Presentation] グレリンの排便中枢を介する結直腸運動亢進作用 (2008)
  • Author(s): 志水泰武, 椎名貴彦
  • Organizer: 第18回病態生理学会
  • Place of Presentation: 神戸
  • Year and Date: 2008-01-26
• [Presentation] Evidence that activation of ghrelin receptors of autonomic preganglionic neurons stimulates autonomic outflows. (2007)
  • Author(s): Shimizu, Y
  • Organizer: 国際自律神経学会
  • Place of Presentation: ISAN2007:京都
  • Year and Date: 2007-10-07
• [Presentation] Evidence that activation of ghrelin receptors of autonomic preganglionic neurons stimulates autonomic outflows. (2007)
  • Author(s): Shimizu. Y
  • Organizer: 5th Congress of the International Society for Autonomic Neuroscience
  • Place of Presentation: 京都
  • Year and Date: 2007-10-07
• [Presentation] Evidence that activation of ghrelin receptors of preganglionic neurons in the spinal cord stimulates colorectal motility and defecation (2007)
  • Author(s): Y. Shimizu, A.D. Shafton, D.M. Ferens, B. Hunne, J.B. Furness
  • Organizer: 国際シンポジウム「Gastrointestinal motility and Functional gastrointestinal disorders, Basic to Clinical」
  • Place of Presentation: 名古屋
  • Year and Date: 2007-08-28
• [Presentation] 脊髄の排便中枢を介するグレリンの結直腸運動亢進作用 (2007)
  • Author(s): 志水泰武, S Anthony, 椎名貴彦, 武脇義, Furness JB.
  • Organizer: 第49回日本平滑筋学会
  • Place of Presentation: 奈良
  • Year and Date: 2007-07-05
• [Book] Chapter 2: The enteric nervous system and its extrinsic connections. (2008)
  • Author(s): Furness, J. B., Nguyen, T. V., Nurgali, K., Shimizu, Y.
  • Publisher: Lippincott
• [Book] Textbook of Gastroenterology, 5th Edition (2008)
  • Author(s): Furness, J. B.
  • Publisher: Wiley-Blackwell