Effevts of the chlorinated derivatives of environmental pollutant on gene expression
| Project/Area Number |
19580383
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Boundary agriculture
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| Research Institution | Shizuoka Eiwa Gakuin University Junior College |
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Principal Investigator |
KURUTO Ryoko Shizuoka Eiwa Gakuin University Junior College, 短期大学部食物学科, 准教授 (50205217)
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| Co-Investigator(Kenkyū-buntansha) |
OHURA Takeshi 静岡県立大学, 環境科学研究所, 助教 (60315851)
TERAO Yoshiyasu 静岡県立大学, 環境科学研究所, 名誉教授 (60046282)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 環境汚染 / 塩素処理 / エストロジェン / 多環芳香族炭化水素 / 遺伝子発現 |
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| Research Abstract |
多環芳香族炭化水素(PAHs)は、ダイオキシン類と同様、様々な燃焼過程で生成され、環境中に排出されている。また、近年PAHsに塩素が付加したClPAHsも、環境中から検出され、これらの塩素置換体は、難分解性、蓄積性が増すため、生体への影響も危惧される。そこで、まず上記物質について、乳がん細胞MCF7を用いて、E2制御のPgR及びpS2、AhR制御のCyp1A1、PCRアレイの遺伝子の発現レベルをReal-time PCRにより解析した。その結果、いくつかの遺伝子で塩素化により発現レベルの変化が認められた。
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Report
(3 results)
Research Products
(40 results)
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[Journal Article] Chlorinated phenanthrenes induce CYP1A1 through aryl hydrocarbon receptor activation2007
Author(s)
Morita, M., Ohura, T., Kuruto-Niwa, R., Sakakibara, H., Amagai, T., Shimoi, K.
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Journal Title
Organohalogen Compd 69
Pages: 1881-1884
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[Presentation] Aryl hydrocarbon receptor-mediated gene expression by chlorinated polycyclic aromatic hydrocarbons2008
Author(s)
Sakakibara, H., Ohura, T., Morita, M., Hirabayashi, S., Kuruto-Niwa, R., Amagai, T., Shimoi, K.
Organizer
愛媛GCOEシンポ
Place of Presentation
愛媛
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[Presentation] A selective inhibitor of CYP1B1, chrysoeriol2007
Author(s)
Takemura, H., Uchiyama, H., Morita, M., Sakakibara, H., Ohura, T., Nagayoshi, H., Matsuda, T., Amagai, T., Kuruto, R., Shimoi, K.
Organizer
1^st Asian Conference on Environmental Mutagens and 36^th Annual Meeting of the Japanese Environmental Mutagen Society
Place of Presentation
北九州
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[Presentation] Modulationg effects of chrysoeriol, a methoxyflavonoid, on CYP1B1 enzyme activity and estrogen metabolism2007
Author(s)
Takemura, H., Uchiyama, H., Morita, M., Sakalibara, H., Ohura, T., Kuruto, R., Amagai, T., Shimoi, K.
Organizer
3^rd International Conference on Polyphenols and Health
Place of Presentation
京都
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[Presentation] Chlorinated phenanthrens induce Cyp1A1 through aryl hydrocarbon receptor activation2007
Author(s)
Morita, M., Ohura, T., Kuruto-Niwa, R., Sakakibara, H., Amagai, T., and Shimoi, K.
Organizer
Dioxin 2007 International Symposium
Place of Presentation
東京
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