The mechanism of diabetic the neuropathic pain : Approach to novel drugs
Project/Area Number |
19590265
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General pharmacology
|
Research Institution | Fukuoka University |
Principal Investigator |
TAKANO Yukio Fukuoka University, 薬学部, 教授 (50113246)
|
Co-Investigator(Kenkyū-buntansha) |
HONDA Kenji 福岡大学, 薬学部, 助教 (60140761)
SAITO Ryo 福岡大学, 薬学部, 講師 (80122696)
MATSUSUE Kimihiko 福岡大学, 薬学部, 准教授 (10389364)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 神経因性疼痛 / 糖尿病 / ムスカリン受容体 / グリア細胞 / インスリン抵抗性 / peroxisome proliferator-activated receptor gamma / ミクログリア / ミノサイクリン / fsp27 / 帯状回 / 坐骨神経部分結紮 / アストロサイト / 肝インスリン抵抗性 |
Research Abstract |
(1) In this study, therefore, we examined the mechanism of diabetic neuropathic pain in detail. Especially, we demonstrated how the spinal muscarinic receptors and the ATP receptors involve in neuropathic pain. In addition, pre-administrations of microglia inhibitor minocycline inhibited the allodynia. (2) Peroxisome proliferator-activated receptor gamma (PPARgamma) is induced in leptin-deficient (ob/ob) mouse liver and is critical for the development of hepatic steatosis. We exanimed that fat-specific protein 27 (Fsp27) in ob/ob liver is a direct target gene of PPARgamma and can elevate hepatic triglyceride levels.
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] Aldosterone-sensitive NTS neurons regulate sensitivity of the baroreceptor reflex in high-sodium loaded rats2010
Author(s)
Masuda T, Hirabara Y, Nakamura Y, Chishaki A, Tsuruhisa M, Miyakawa M, Honda K, Saito R, Sakamoto H, Kawata M, TakanoY
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Journal Title
J. Pharmacol. Sci. 112
Pages: 482-486
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[Journal Article] Involvement of Na+/Ca2+ exchanger in pentylenetetrazol-induced convulsion by use of Na+/Ca2+ exchanger knockout mice2009
Author(s)
Saito R., Kaneko, E., Tanaka, Y., Honda, K., Matsuda, T., Baba, A., Komuro, I., Kita, S., Iwamoto, T., Takano Y.
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Journal Title
Biol.Pharma.Bull. 32
Pages: 1298-1930
NAID
Related Report
Peer Reviewed
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[Journal Article] Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype2008
Author(s)
Gang Zhu, M Okada, Yoshida S, Ueno S, Mori F, Takahara T, Saito R, Miura Y, Kishi A, Tomiyama M, Sato A, Kojima T, Fukuma G, Wakabayashi K, Hase K, Ohno H, Kijima H, Takano Y, Mitsudome A, Kaneko S, Hirose S
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Journal Title
J. Neuroscience 28
Pages: 12465-12476
Related Report
Peer Reviewed
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[Journal Article] Contribution of Ca2+-dependent protein kinase C in the cord to spinal the development of mechanical allodynia in diabetic mice2007
Author(s)
Honda, K. Koguchi, M., Koga, K. Nakajima, K. Kobayashi, F. Migita, K. Ogata, S, Hirabara, Y. Takano, Y.
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Journal Title
Biol.Pharma.Bull 301
Pages: 990-993
Related Report
Peer Reviewed
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[Journal Article] A high-sodium diet in streptozotocin-induced diabetic rats impairs endothelium-derived hyperpolarizing factor-mediated vasodilation2007
Author(s)
Hirabara, Y., Araki, M., Fukuda, M., KatafUchi, S., Honda, K. Saito, R., and Takano, Y.
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Journal Title
J.Pharmacol.Sci 104
Pages: 402-40
NAID
Related Report
Peer Reviewed
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[Journal Article] Aldosterone-sensitive NTS neurons regulate sensitivity of the baroreceptor reflex in high-sodium loaded rats
Author(s)
Masuda T, Hirabara Y, Nakamura Y, Chishaki A, Tsuruhisa M, Miyakawa M, Honda K, Saito R, Sakamoto H, Kawata M, Takano Y
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Journal Title
J.Pharmacol.Sci. 112(In press)
Related Report
Peer Reviewed
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[Presentation] CCL1の神経因性疼痛への関与2010
Author(s)
秋元望, 本多健治, 牛島悠一, 松崎雄, 中島茂人, 斎藤亮, 高野行夫
Organizer
第83回日本薬理学会
Place of Presentation
国際会議場(大阪)
Year and Date
2010-03-16
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[Presentation] モデルラットにおいて動脈圧受容器反射は減弱する;弧束核におけるアルドステロン感受性神経2009
Author(s)
増田大治, 中村祐介, 宮川雅行, 平原康寿, 本多健治, 斎藤亮, 有森和彦, 中川裕之, 坂本浩隆, 河田光博, 高野行夫, 糖尿病・食塩負荷
Organizer
第82回日本薬理学会年会
Place of Presentation
横浜
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