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Elucidation of the mechanism for cell adhesion between LAM cells and lymphatic endothelial cells in the LAM cell clusters

Research Project

Project/Area Number 19590406
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionJuntendo University

Principal Investigator

KUMASAKA Toshio  Juntendo University, 医学部, 准教授 (00286709)

Co-Investigator(Kenkyū-buntansha) SEYAMA Kuniaki  順天堂大学, 医学部, 准教授 (10226681)
Research Collaborator 林 大久生  順天堂大学, 医学部, 大学院生
三谷 恵子  順天堂大学, 医学部, 技術員
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsリンパ脈管筋腫症 / リンパ脈管筋腫症細胞集塊 / リンパ増殖因子 / リンパ内皮細胞 / 細胞接着分子 / 細胞外マトリックス / 肺リンパ脈管筋腫症 / LAM cell cluster(LCC) / 接着因子
Research Abstract

転移する良性腫瘍である平滑筋腫様細胞であるリンパ脈管筋腫症(LAMと略す)細胞はリンパ管新生能を有するため、自ら新生したリンパ管により腫瘍結節がリンパ管内皮細胞に覆われたまま細片化され、リンパ管腔ならびに体腔内に放出される。本研究では患者LAM細胞集塊(LCCと略す)には特異的な細胞接着分子や細胞外マトリックスの発現が見られ、人工的に作製されたの研究に重要なツールとなる可能性がある。LCC様細胞集塊にもその一部の細胞外マトリックスが発現していた。人工LCCは今後のLAM

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (17 results)

All 2009 2008 2007 Other

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (8 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Lymphangioleiomyomatosis diagnosed by immunocytochemical and genetic analysis of lymphangioleiomyomatosis cell clusters found in chylous pleural effusion2007

    • Author(s)
      Hirama M, Atsuta R, Mitani K, Kumasaka T, Gunji Y, Sasaki S, Iwase A, Takahashi K, Seyama K
    • Journal Title

      Intern Med 46

      Pages: 1593-6

    • NAID

      130000076007

    • Related Report
      2008 Final Research Report
  • [Journal Article] The epidemiology of lymphangioleiomyomatosis in Japan:a nationwide cross-sectional study of presenting features and prognostic factors2007

    • Author(s)
      Hayashida M, et. al.
    • Journal Title

      Respirology1 12

      Pages: 523-530

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lymphangioleiomyomatosis diagnosed by immunocytochemical and genetic analysisof lymphangioleiomyomatosis cell clusters found in chylous pleural effusion2007

    • Author(s)
      Hirama M, et. al.
    • Journal Title

      Internal Medicine 46

      Pages: 1593-1596

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LAMは腫瘍か2007

    • Author(s)
      瀬山 邦明, 他
    • Journal Title

      呼吸 26

      Pages: 23-30

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Cytological, Immunocytochemical, and Ultrastructural Characterization of LAM Cell Clusters in the Chylous Effusion of Patients with Lymphangioleiomyomatosis

    • Author(s)
      Mitani K, Kumasaka T, Takemura H, Hayashi T, Gunji Y, Kunogi M, Akiyoshi T, Takahashi K, Suda K, Seyama K
    • Journal Title

      ActaCytologica (in press)

    • Related Report
      2008 Final Research Report
  • [Presentation] 重症リンパ脈管筋腫症における中枢気道の病理学的解析2008

    • Author(s)
      熊坂利夫, 三谷恵子, 林大久生, 山鳥一郎, 瀬山邦明
    • Organizer
      日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 重症肺リンパ脈管筋腫症における中枢気道障害の病理組織学的解析2008

    • Author(s)
      熊坂利夫, 三谷恵子, 林大久生, 山鳥一郎, 瀬山邦明
    • Organizer
      日本病理学会総会
    • Place of Presentation
      金沢市・おもてなしホール
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 乳び体腔液中LAM cell cluster (LCC)の細胞学的特徴とその意義2008

    • Author(s)
      三谷恵子, 熊坂利夫, 林大久生, 須田耕一, 山鳥一郎, 郡司陽子, 秋吉妙子, 瀬山邦明
    • Organizer
      日本呼吸器学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 乳糜胸水合併LAM症例における低用量GnRH療法の効果2008

    • Author(s)
      郡司陽子, 瀬山邦明, 熊坂利夫, 三谷恵子, 佐藤輝彦, 秋吉妙子, 小池建吾, 高橋和久
    • Organizer
      日本呼吸器学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Cytological,Immunocytochemical,and Ultrastructual Characterization of LAM Cell Clusters in Chylous Effusion in Patients with Lymphangioleiomyomatosis2007

    • Author(s)
      Mitani K, et. al.
    • Organizer
      LAMposium2007
    • Place of Presentation
      Cincinnati,OH
    • Year and Date
      2007-04-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effect of long term administration of gonadotropin-releasing hormone analogues on chylous effusion in patients with lymphangioleiomyomatosis2007

    • Author(s)
      Seyama K, Sato T, Gunji Y, Kumasaka T, Mitani K, Akiyoshi T, Tobino K, Hayashi T
    • Organizer
      LAM Foundation 2007 lymphangiogenesis international research conference
    • Related Report
      2008 Final Research Report
  • [Presentation] Cytological, immunocytochemical, and ultrastructual characterization of LAM cell clusters in Chylous Effusion in patients with Lymphangioleiomyomatosis2007

    • Author(s)
      Mitani K, Kumasaka K, Takemura H, Hayashi T, Hosokawa Y, Suda K, Gunji Y, Akiyoshi T, Seyama K
    • Organizer
      The LAM Foundation 2007 lymphangiogenesis international research conference
    • Related Report
      2008 Final Research Report
  • [Presentation] Loss of Heterozygosity of the TSC Genes and Overexpression of mTOR-related Proteins in Multifocal Micronodular Pneumocyte Hyperplasia (MMPH) of the Lung2007

    • Author(s)
      Hayashi T, Kumasaka T, Mitani K, Gunji Y, Suda K, Seyama K
    • Organizer
      The LAM Foundation 2007 lymphangiogenesis international research conference
    • Related Report
      2008 Final Research Report
  • [Book] Lymphangioleiomyomatosis : In Lymphangiogenesis and Cancer Metastasis2009

    • Author(s)
      Seyama K. Kumasaka T, Sato T, Mitani K.
    • Publisher
      Springer London(In press)
    • Related Report
      2008 Annual Research Report
  • [Book] Lymphangioleiomyomatosis. Lymphangiogenesis and Cancer Metastasis. Edited by Stacker SA and Achen MG

    • Author(s)
      Seyama K. Kumasaka T, Sato T, Mitani K
    • Publisher
      Springer London(in press)
    • Related Report
      2008 Final Research Report
  • [Remarks] 気胸・肺嚢胞スタディグループホームページ

    • URL

      http://kikyoustudy.wordpress.com

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://kikyoustudy.wordpress.com

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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