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Study on the survival mechanism of Schistosoma mansoni-infected mice against fulminant hepatitis induced by injection with LPS and D-galactosamine

Research Project

Project/Area Number 19590435
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Parasitology (including Sanitary zoology)
Research InstitutionKeio University

Principal Investigator

TANABE Masanobu  Keio University, 医学部, 講師 (80051928)

Co-Investigator(Kenkyū-buntansha) FUKAO Taro  Max-Planck-Institute of Immunobiology, Freiburg, Germany, 主任研究員 (20401127)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsマンソン住血吸虫 / リポポリサッカライド / D-ガラクトサミン / アポトーシス / 急性肝障害 / 劇症肝炎 / 凝固活性化リポ蛋白
Research Abstract

致死量のリポポリサッカライドとD-ガラクトサミン(LPS/D-GalN)投与による急性肝障害に対するマンソン住血吸虫(Sm)感染、あるいはCILIP投与マウスのサバイバル機構を解析した。これらのマウスでは、LPS/D-GalN投与による肝細胞アポトーシスの抑制が生存に不可欠であり、Sm感染マウスでは、iNOSがその抑制に関与していることが示唆された。CILIP投与マウスの救命機構は特定できていないが、住血吸虫由来物質がその救命に働いている可能性が示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (8 results)

All 2009 2008 2007

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results)

  • [Journal Article] Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells2008

    • Author(s)
      Ohtani M, Nagai S, Kondo S, Mizuno S, Nakamura K, Tanabe M,, et al.
    • Journal Title

      Blood 112(3)

      Pages: 635-643

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaocharide-induced interleukin-12 production in dendritic cells.2008

    • Author(s)
      Ohtani M, Nagai S, Kondo S, Mizuno S, Nakamura K, Tanabe M, et al.
    • Journal Title

      Blood 112(3)

      Pages: 635-643

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An evolutionarily conserved mechanism for microRNA-223 expression revealed by microRNA gene profiling2007

    • Author(s)
      Fukao T, Tanabe M, et. al.
    • Journal Title

      Cell P29

      Pages: 617-631

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] In vitroにおける凝固活性化リポ蛋白(CILIP)の誘導とその劇症肝炎抑制効果2009

    • Author(s)
      田邊將信、深尾太郎、永田博司、関塚永一、宮崎耕司、竹内勤
    • Organizer
      第78回日本寄生虫学会大会
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Resistance of the chronically infected mice with Schistosoma mansoni against lipopolysaccharide (LPS)-induoecl fulminant hepatitis2008

    • Author(s)
      Tanabe M, Fukao T, Takeda, K, Fukuda, Y, Nara T, Ohta N, et al.
    • Organizer
      17th International Congress of Tropical Medicine and Malaria
    • Place of Presentation
      韓国済州島
    • Year and Date
      2008-10-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 慢性マンソン住血吸虫感染マウスはPseudomonas aeruginosa致死感染に対し抵抗性である2008

    • Author(s)
      田邊將信、深尾太郎、永田博司、関塚永一、宮崎耕司、竹内勤
    • Organizer
      第77回日本寄生虫学会大会
    • Place of Presentation
      長崎県長崎市
    • Year and Date
      2008-04-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 慢性マンソン住血吸虫感染マウスは Pseudomonas aeruginosa致死感染に対し抵抗性である2008

    • Author(s)
      田邊將信, 深尾太郎, 永田博司, 関塚永一, 宮崎耕司, 竹内勤
    • Organizer
      第77回日本寄生虫学会大会
    • Place of Presentation
      長崎県長崎市
    • Year and Date
      2008-04-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Resistance of the chronically infected mice with Schistosoma mansoni againstlipopolysaccharide (LPS)-induced fulminant hepatitis2008

    • Author(s)
      Tanabe M, Fukao T, Takeda, K, Fukuda, Y, Nara T, Ohta N, et al.
    • Organizer
      17th International Congress of Tropical Medicine and Malaria
    • Place of Presentation
      韓国済州島
    • Year and Date
      2008-01-01
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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