| Project/Area Number |
19590732
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
HIGUCHI Kazuhide Osaka Medical College, 医学部, 教授 (20218697)
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| Co-Investigator(Kenkyū-buntansha) |
TOMINAGA Kazunari 大阪市立大学, 大学院・医学研究科, 准教授 (80336768)
FUJIWARA Yasuhiro 大阪市立大学, 大学院・医学研究科, 准教授 (40285292)
WATANABE Toshio 大阪市立大学, 大学院・医学研究科, 准教授 (50336773)
TANIGAWA Tetsuya 大阪市立大学, 大学院・医学研究科, 講師 (70423879)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | アディポサイトカイン / アディポネクチン / 炎症 / Helicobacter pylori / 胃炎 / tumor necrosis factor-・ / tumor necrosis factor / interleukin-8 / Interleukin-8 |
|---|
| Research Abstract |
Adiponectin, one of the adipocytokines which is produced by adipose tissue, has anti-diabetic, anti-atherosclerotic, anti-inflammatory and anti-carcinogenic effects. In this study, we studied the involvement of adiponectin on Helicobacter pylori (H.pylori)-induced gastritis.
1. Adiponectin suppress production of proinflammatory cytokines TNF-・ produced by THP-1 cells stimulated by H.pylori-water soluble extract.
2. Leptin, one of the important adipocitykines as well as adiponectin, promotes the healing of gastric ulcer via upregulation of vascular endothelial growth factor.
3. IL-17A exerts anti-inflammatory effect on H.pylori -induced gastritis through suppression of Th1 differentiation.
4. Bile acids may induce gastric intestinal metaplasia and carcinogenesis through the farnesoid X receptor (FXR), a nuclear receptor for bile acids.
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