The Significance of Adiponectin in Atrophic Gastritis and Gastric Carcinogenesis
| Project/Area Number |
19590732
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
HIGUCHI Kazuhide Osaka Medical College, 医学部, 教授 (20218697)
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| Co-Investigator(Kenkyū-buntansha) |
TOMINAGA Kazunari 大阪市立大学, 大学院・医学研究科, 准教授 (80336768)
FUJIWARA Yasuhiro 大阪市立大学, 大学院・医学研究科, 准教授 (40285292)
WATANABE Toshio 大阪市立大学, 大学院・医学研究科, 准教授 (50336773)
TANIGAWA Tetsuya 大阪市立大学, 大学院・医学研究科, 講師 (70423879)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | アディポサイトカイン / アディポネクチン / 炎症 / Helicobacter pylori / 胃炎 / tumor necrosis factor-・ / tumor necrosis factor / interleukin-8 / Interleukin-8 |
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| Research Abstract |
Adiponectin, one of the adipocytokines which is produced by adipose tissue, has anti-diabetic, anti-atherosclerotic, anti-inflammatory and anti-carcinogenic effects. In this study, we studied the involvement of adiponectin on Helicobacter pylori (H.pylori)-induced gastritis.
1. Adiponectin suppress production of proinflammatory cytokines TNF-・ produced by THP-1 cells stimulated by H.pylori-water soluble extract.
2. Leptin, one of the important adipocitykines as well as adiponectin, promotes the healing of gastric ulcer via upregulation of vascular endothelial growth factor.
3. IL-17A exerts anti-inflammatory effect on H.pylori -induced gastritis through suppression of Th1 differentiation.
4. Bile acids may induce gastric intestinal metaplasia and carcinogenesis through the farnesoid X receptor (FXR), a nuclear receptor for bile acids.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Bile acids induce cdx2 expression through the fanesoid x receptor in gastric epithelial cells.2010
Author(s)
Xu Y, Watanabe T, Tanigawa T, Machida H, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T.
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Journal Title
J Clin Biochem Nutr. 46(1)
Pages: 81-6
Related Report
Peer Reviewed
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[Journal Article] Leptin promotes gastric ulcer healing via upregulation of vascular endothelial growth factor.2010
Author(s)
Tanigawa T, Watanabe T, Otani K, Nadatani Y, Machida H, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T.
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Journal Title
Digestion 81(2)
Pages: 86-95
Related Report
Peer Reviewed
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[Journal Article] 胃潰瘍治癒過程におけるレプチンの意義2009
Author(s)
谷川徹也, 渡辺俊雄, 町田浩久, 岡崎博俊, 山上博一, 渡辺憲治, 富永和作, 藤原靖弘, 押谷伸英, 樋口和秀, 荒川哲男
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Journal Title
Progress in Medicine 29巻3号
Pages: 779-781
Related Report
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