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A novel mouse model of diabetic nephropathy : MafA-deficient and beta cell-specific MafK-overexpressing hybrid transgenic

Research Project

Project/Area Number 19590933
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionUniversity of Tsukuba

Principal Investigator

YOH Keigyou  University of Tsukuba, 大学院・人間総合科学研究科, 准教授 (90323302)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords糖尿病 / 糖尿病性腎症 / Maf群タンパク質 / 転写因子 / Maf
Research Abstract

We generated hybrid transgenic mice that were MafA-deficient and also overexpressed MafK specifically in beta cells (MafA-/-MafK+). MafA-/-MafK+ mice developed severe overt diabetes mellitus within 5 weeks old. Furthermore, after uninephrectomy, these mice demonstrated three characteristics of human diabetic nephropathy : diffuse, nodular, and exudative lesions. MafA-/-MafK+ mice might be a useful model for the analysis of human diabetic nephropathy.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (6 results)

All 2009 2007

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] MafA-deficient and beta cell-specific MafK-overexpressing hybrid transgenic mice develop human-like severe diabetic nephropathy2009

    • Author(s)
      Shimohata H, Yoh K, Fujita A, Morito N, Ojima M, Tanaka H, Hirayama K, Kobayashi M, Kudo T, Yamagata K, Takahashi, S.
    • Journal Title

      Biochem Biophys Res Commun. 389(2)

      Pages: 235-40

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] MafA-deficient and beta cell-specific MafK-overexpressing hybrid transgenic mice develop human-like severe diabetic nephropathy2009

    • Author(s)
      H.Shimohata, K.Yoh, et al.
    • Journal Title

      Biochemical and Biophysical Research Communications Vol.389

      Pages: 235-240

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] MafAKO : MafKTg compound mouse は重篤な糖尿病性腎症を呈する2009

    • Author(s)
      藤田亜紀子, 楊景堯, 下畑誉, 森戸直記, 山縣邦弘
    • Organizer
      第1回 Advans 研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-12-26
    • Related Report
      2009 Final Research Report
  • [Presentation] MafAKO : MafKTg compound mouseは重篤な糖尿病性腎症を呈する2009

    • Author(s)
      藤田亜紀子、楊景堯, 他
    • Organizer
      第1回Advans研究会
    • Place of Presentation
      名古屋マリオットアソシナホテル(愛知県)
    • Year and Date
      2009-12-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] MafA-deficient/MafK transgenic hybrid mice develop severe diabetic nephropathy2007

    • Author(s)
      N. Morito, H. Shimohata, Y. Hashimoto, K. Yoh, K. Yamagata, S. Takahashi
    • Organizer
      American Society of Nephrology Renal Week
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-11-02
    • Related Report
      2009 Final Research Report
  • [Presentation] MafA-deficient/MafK transgenic hybrid mice develop severe diabetic nephropathy2007

    • Author(s)
      N. Morito, K. Yoh, 他
    • Organizer
      American Society of Nephrology Renal Week
    • Place of Presentation
      San Francisco
    • Year and Date
      2007-11-02
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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