| Project/Area Number |
19591045
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
|
|---|
| Research Institution | Shiga University of Medical Science |
|---|
Principal Investigator |
UGI Satoshi Shiga University of Medical Science, 医学部, 助教 (20378483)
|
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Shiro 独立行政法人理化学研究所, 遺伝子多型センター, チームリーダー (50314159)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
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| Keywords | メタボリックシンドローム / 内臓脂肪 / アジポカイン / AP2β / 糖尿病 / 皮下脂肪 / アディポサイトカイン / 脂肪細胞 |
|---|
| Research Abstract |
To determine the potential role of TFAP2B in the regulation of expression of adiponectin, leptin and interleukin-6 (IL-6) in vivo, we quantified the mRNA expression levels of these adipokines and TFAP2B in visceral (omental) and abdominal subcutaneous adipose tissues of 66 individuals and studied their correlations. We found that TFAP2B mRNA correlated negatively with adiponectin expression in the subcutaneous adipose tissue. Furthermore, TFAP2B mRNA expression correlated negatively with leptin and positively with IL-6 expression in both subcutaneous and omental adipose tissues. These relationships are consistent with our in vitro observations and indicate that TFAP2B seems to regulate the expression of various adipokines in vivo.
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