| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
Airway inflammation in asthma is associated with airway obstruction and airway hyperresponsiveness. It is generally assumed that steroid therapy reduces airway inflammation. However, not all individuals respond similarly to steroid like as difficult asthma. Exhaled breath condensate (EBC) analysis is a noninvasive method for assessing inflammatory molecules in the airways. This study demonstrated that increased IL-4 and RANTES levels as well as decreased IP-10 levels at baseline were correlated with an improvement in airway obstruction. EBC measurements of IL-4, RANTES and IP-10 might be useful for predicting the steroid-resistant asthma.
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