Comprehensive study on the β-lactamase producing organisms in clinical isolates
| Project/Area Number |
19591185
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Toho University |
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Principal Investigator |
ISHII Yoshikazu Toho University, 医学部, 助教 (90246695)
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| Co-Investigator(Kenkyū-buntansha) |
舘田 一博 東邦大学, 医学部, 准教授 (20236558)
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| Co-Investigator(Renkei-kenkyūsha) |
TATEDA Kazuhiro 東邦大学, 医学部, 准教授 (20236558)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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|---|
| Keywords | 薬剤耐性菌 / β-ラクラマーゼ / 多剤耐性 / 薬剤感受性サーベイランス / β-ラクタマーゼ |
|---|
| Research Abstract |
The aim of this study was to survey the antibiotic resistant bacteria in Japan and to analyze their mechanisms of resistance. The results of this study show increasing β-lactam resistance in Acinetobacte species and enterobacteriaceae. The main resistance mechanisms of enterobacteriaceae and Acinetobacter species was the production of β-lactam hydrolyzing enzymes. Antibiotic impermeability was the main resistance mechanism forPseudomonas aeruginosa. This project also elucidated the genetic basis for spread of the resistance genes.
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Report
(4 results)
Research Products
(71 results)
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[Journal Article] Sequential changes of Legionella antigens and bacterial load in the lungs and urines of a mouse model of pneumonia.2010
Author(s)
Chen Y, Tateda K, Fujita K, Ishii T, Ishii Y, Kimura S, Saga T, Annaka T, Yamada S, Zhao L, Li S, Azuma A, Gemma A, Kudoh S, Yamaguchi K
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Journal Title
Diagn Microbiol Infect Dis 66
Pages: 253-260
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Peer Reviewed
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[Presentation] SHV-12, DHA-1βラクタマーゼ産生Klebsiella pneumoniaeが分離された1症例~経過中に出現したカルバペネム系耐性菌の機序と臨床背景の検討~.2009
Author(s)
山田友紀, 石井良和, 畠山裕司, 昆浩, 黒田牧子, 伊東みち子, 野々宮百合子, 山端久美子, 山口惠三, 諏訪部章
Organizer
第20回日本臨床微生物学会
Place of Presentation
仙台
Year and Date
2009-01-31
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[Book] 日本臨床2007
Author(s)
石井良和
Total Pages
5
Publisher
株式会社日本臨床社
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