Comprehensive study on the β-lactamase producing organisms in clinical isolates

• Project/Area Number: 19591185
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Toho University
• Principal Investigator: ISHII Yoshikazu Toho University, 医学部, 助教 (90246695)
• Co-Investigator(Kenkyū-buntansha): 舘田 一博 東邦大学, 医学部, 准教授 (20236558)
• Co-Investigator(Renkei-kenkyūsha): TATEDA Kazuhiro 東邦大学, 医学部, 准教授 (20236558)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 薬剤耐性菌 / β-ラクラマーゼ / 多剤耐性 / 薬剤感受性サーベイランス / β-ラクタマーゼ

Research Abstract

The aim of this study was to survey the antibiotic resistant bacteria in Japan and to analyze their mechanisms of resistance. The results of this study show increasing β-lactam resistance in Acinetobacte species and enterobacteriaceae. The main resistance mechanisms of enterobacteriaceae and Acinetobacter species was the production of β-lactam hydrolyzing enzymes. Antibiotic impermeability was the main resistance mechanism forPseudomonas aeruginosa. This project also elucidated the genetic basis for spread of the resistance genes.

Research Products

• [Journal Article] Sequential changes of Legionella antigens and bacterial load in the lungs and urines of a mouse model of pneumonia. (2010)
  • Author(s): Chen Y, Tateda K, Fujita K, Ishii T, Ishii Y, Kimura S, Saga T, Annaka T, Yamada S, Zhao L, Li S, Azuma A, Gemma A, Kudoh S, Yamaguchi K
  • Journal Title: Diagn Microbiol Infect Dis 66 Pages: 253-260
  • Peer Reviewed
• [Journal Article] The catalytic efficiency kcat/Km of the class Aβ-lactamase Toho-1 correlates with the thermal stability of its catalytic intermediate analog. (2010)
  • Author(s): Nitanai Y, Shimamura T, Uchiyama T, Ishii Y, Takehira M, Yutani K, Matsuzawa H, Miyano M
  • Journal Title: Biochim Biophys Acta 1804 Pages: 684-691
  • Peer Reviewed
• [Journal Article] The catalytic efficiency k_<cat>/K_m of the class A β-lactamase Toho-1 correlates with the thermal stability of its catalytic intermediate analog (2010)
  • Author(s): Nitanai Y, Shimamura T, Uchiyama T, Ishii Y, Takehira M, Yutani K, Matsuzawa H, Miyano M
  • Journal Title: Biochim Biophys Acta 1804 Pages: 684-691
  • Peer Reviewed
• [Journal Article] High prevalence of the aac(6')-Ib-cr gene and its dissemination among Enterobacteriaceae isolates by CTX-M-15 plasmids in Bulgaria. (2009)
  • Author(s): Sabtcheva S, Kaku M, Saga T, Ishii Y, Kantardjiev T
  • Journal Title: Antimicrob Agents Chemother 53 Pages: 335-336
  • Peer Reviewed
• [Journal Article] Characterization of Klebsiella pneumoniae producing SHV-12 and DHA-1β-lactamases accompanied by carbapenem resistance during hospitalization in a chronic care ward in Japan. (2009)
  • Author(s): Yamada Y, Ishii Y, Kouyama Y, Katho M, Odashiro R, Yamahata K, Tateda K, Yamaguchi K, Suwabe A
  • Journal Title: J Chemother 21 Pages: 445-447
  • Peer Reviewed
• [Journal Article] Efficacy of colistin combination therapy in a mouse model of pneumonia caused by multidrug-resistant Pseudomonas aeruginosa. (2009)
  • Author(s): Aoki N, Tateda K, Kikuchi Y, Kimura S, Miyazaki C, Ishii Y, Tanabe Y, Gejyo F, Yamaguchi K
  • Journal Title: J Antimicrob Chemother 63 Pages: 534-542
  • Peer Reviewed
• [Journal Article] A low concentration of azithromycin inhibits the mRNA expression of N-acyl homoserine lactone synthesis enzymes, upstream of lasI or rhlI, in Pseudomonas aeruginosa. (2009)
  • Author(s): Kai T, Tateda K, Kimura S, Ishii Y, Ito H, Yoshida H, Kimura T, Yamaguchi K
  • Journal Title: Pulm Pharmacol Ther 22 Pages: 483-486
  • Peer Reviewed
• [Journal Article] Characterization of Klebsiella pneumoniae producing SHV-12 and DHA-1 β-lactamases accompanied by carbapenem resistance during hospitalization in a chronic care ward in Japan (2009)
  • Author(s): Yamada Y, Ishii Y, Kouyama Y, Katho M, Odashiro R, Yamahata K, Tateda K, Yamaguchi K, Suwabe A
  • Journal Title: J Chemother. 21 Pages: 445-447
  • Peer Reviewed
• [Journal Article] High prevalence of the aac(6')-Ib-cr gene and its dissemination among Enterobacteriaceae isolates by CTX-M-15 plasmids in Bulgaria (2009)
  • Author(s): Sabtcheva S, Kaku M, Saga T, Ishii Y, Kantardjiev T
  • Journal Title: Antimicrob Agents Chemother 53 Pages: 335-336
  • Peer Reviewed
• [Journal Article] vanA型Vancomycin-resistant enterococci病棟内伝播事例への対応 (2009)
  • Author(s): 鈴木高弘, 伊藤章, 佐々木由香, 佐々木隆, 篠永正道, 廣井みどり, 石井良和, 山口惠三
  • Journal Title: 環境感染誌 6024 Pages: 113-118
  • NAID: 10024804285
  • Peer Reviewed
• [Journal Article] the JARS Participants Group: Evaluation of Antimicrobial Susceptibility for β-Lactams Using the Etest Method against Clinical Isolates from 100 Medical Centers in Japan (2006). (2008)
  • Author(s): Ishii Y, Tateda K, Yamaguchi K
  • Journal Title: Diagn Microbiol Infect Dis 60 Pages: 177-183
  • Peer Reviewed
• [Journal Article] the Meropenem Surveillance Group in Japan: Evaluation of the Susceptibility Trends to Meropenem in a Nationwide Collection of Clinical Isolates in Japan: a Longitudinal Analysis from 2002 to 2006. (2008)
  • Author(s): Ishii Y, Yamaguchi K
  • Journal Title: Diagn Microbiol Infect Dis 61 Pages: 346-350
  • Peer Reviewed
• [Journal Article] Extended-spectrum β-Lactamases: Implications for the Clinical Laboratory and Therapy. (2008)
  • Author(s): Harada S, Ishii Y, Yamaguchi K
  • Journal Title: Korean J Lab Med 28 Pages: 401-412
  • Peer Reviewed
• [Journal Article] Characterization of the metallo-βlactamase VIM-6 and its genetic support. (2008)
  • Author(s): Koh TH, Yamaguchi K, Ishii Y
  • Journal Title: Int J Antimicrob Agents 32 Pages: 446-449
  • Peer Reviewed
• [Journal Article] Nosocomial spread of armA-mediated high-level aminoglycoside resistance in Enterobacteriaceae isolates producing CTX-M-3βlactamase in a cancer hospital in Bulgaria. (2008)
  • Author(s): Sabtcheva S, Saga T, Kantardjiev T, Ivanova M, Ishii Y, Kaku M
  • Journal Title: J Chemother 20 Pages: 593-599
  • Peer Reviewed
• [Journal Article] Efficacy of colistin combination therapy in a mouse model of pneumonia caused by multidrug-resistant Pseudomonas aeruginosa (2008)
  • Author(s): Aoki N, Tateda K, Kikuchi Y, Kimura S, Miyazaki C, Ishii Y, Tanabe Y, Gejyo F, Yamaguchi K.
  • Journal Title: J Antimicrob Chemother 63 Pages: 534-542
  • Peer Reviewed
• [Journal Article] Extended-spectrum β-Lactamases : Implications for the Clinical Laboratory and Therapy. (2008)
  • Author(s): Harada S, Ishii Y, Yamaguchi K.
  • Journal Title: Korean J Lab Med. 28 Pages: 401-412
  • Peer Reviewed
• [Journal Article] Characterization of the metallo-β-lactamase VIM-6 and its genetic support. (2008)
  • Author(s): Tse Hsien Koh, Keizo Yamaguchi, Yoshikazu Ishii
  • Journal Title: Int J Antimicrob Agents 32 Pages: 446-449
  • Peer Reviewed
• [Journal Article] Evaluation of the Susceptibility Trends to Meropenem in a Nationwide Collection of Clinical Isolates in Japan : a Longitudinal Analysis from 2002 to 2006. (2008)
  • Author(s): Ishii Y, Yamaguchi K, & the Meropenem Surveillance Group in Japan
  • Journal Title: Diagn Microbiol Infect Dis 61 Pages: 346-350
  • Peer Reviewed
• [Journal Article] Evaluation of Antimicrobial Susceptibility for β-Lactams Using the Etest Method against Clinical Isolates from 100 Medical Centers in Japan (2006) (2008)
  • Author(s): Ishii Y, Tateda K, Yamaguchi K, the JARS Participants Group
  • Journal Title: Diagn Microbiol Infect Dis 60 Pages: 177-183
  • Peer Reviewed
• [Journal Article] Evaluation of the Susceptibility Trends to Meropenem in a Nationwide Collection of Clinical Isolates in Japan: a Longitudinal Analysis from 2002 to 2006 (2008)
  • Author(s): Ishii Y, Yamaguchi K, and the Meropenem Surveillance Group in Japan
  • Journal Title: Diagn Microbiol Infect Dis (印刷中)
  • Peer Reviewed
• [Journal Article] Evaluation of Antimicrobial Susceptibility fbr β-Lactams Using the Etest Method against Clinical Isolates from 100 Medical Centers in Japan(2006) (2008)
  • Author(s): Ishii Y, Tateda K, Yamaguchi K and the JARS Participants Group
  • Journal Title: Diagn Microbiol Infect Dis 60 Pages: 177-183
  • Peer Reviewed
• [Journal Article] Detailed biochemical characterization of the CTX-M-14β-lactamase. (2007)
  • Author(s): Ishii Y, Galleni M, Ma L, Frere JM, Yamaguchi K
  • Journal Title: Int J Antimicrob Agents 29 Pages: 159-164
  • Peer Reviewed
• [Journal Article] Suppression of Pseudomonas aeruginosa quorum-sensing systems by macrolides: a promising strategy or an oriental mystery (2007)
  • Author(s): Tateda K, Ishii Y, Kimura S, Horikawa M, Miyairi S, Yamaguchi K
  • Journal Title: J Infect Chemother 13 Pages: 357-367
  • NAID: 10020023264
  • Peer Reviewed
• [Journal Article] Detailed biochemical characterization of the CTX-M-14 β-lactamase (2007)
  • Author(s): Ishii Y, Galleni M, Ma L, Frere JM and Yamaguchi K
  • Journal Title: Int J Antimicrob Agents 29 Pages: 159-164
  • Peer Reviewed
• [Journal Article] Stability of FR264205 against AmpC β-lactamase of Pseudomonas aeruginosa (2007)
  • Author(s): Takeda s, Ishii Y, Hatano K, Tateda K, Yamaguchi K
  • Journal Title: Int J Antimicrob Agents 30 Pages: 443-445
  • Peer Reviewed
• [Journal Article] Nosocomial outbreak by genetically related IMP-1 β-lactamase producing Klebsiella pneumoniae in a general hospital (2007)
  • Author(s): Fukigai S, Alba J, Kimura S, Iida T, Nishikura N, Ishii Y and Yamaguchi K
  • Journal Title: Int J Antimicrob Agents 29 Pages: 306-310
  • Peer Reviewed
• [Journal Article] Predictive analysis of ceftazidime hydrolysis in CTX-M-type β-lactamase family members with a mutational substitution at position 167 (2007)
  • Author(s): Kimura S, Ishii Y, Tateda K and Yamaguchi K
  • Journal Title: Int J Antimicrob Agents 29 Pages: 326-331
  • Peer Reviewed
• [Journal Article] 下気道感染由来および尿路感染由来緑膿菌の薬剤感受性(2004年〜2005年) (2007)
  • Author(s): 石井良和, 大野章, 岩田守弘, 村上日奈子, 山口惠三
  • Journal Title: 日本化学療法雑誌 55 Pages: 278-285
  • NAID: 10019531077
  • Peer Reviewed
• [Journal Article] Extended-spectrum β lactamase(ESBL)産生大腸菌による尿路感染症の臨床的検討 (2007)
  • Author(s): 堀淳一, 山口聡, 小山内裕昭, 杵渕貴洋, 宇佐美和男, 高橋尚志, 石井良和
  • Journal Title: 泌尿紀要 53 Pages: 777-782
  • NAID: 120001177954
  • Peer Reviewed
• [Presentation] 検査と治療のUpdate 2.日常検査におけるβラクタマーゼのクラス別検出法と抗菌薬選択に関する考察. (2010)
  • Author(s): 石井良和
  • Organizer: 第21回日本臨床微生物学会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-30
• [Presentation] 検査と治療の Update 2. 日常検査におけるβラクタマーゼのクラス別検出法と抗菌薬選択に関する考察 (2010)
  • Author(s): 石井良和
  • Organizer: 第21回日本臨床微生物学会
  • Place of Presentation: 東京
• [Presentation] Isolation Frequency of Extended-Spectrum s-Lactamases Producing E. coli, K. pneumoniae or P. mirabilis and Metallo-s-Lactamases Producing P. aeruginosa from 72 Centres in Japan, 2007. (2009)
  • Author(s): Ishii Y. Ohno A., Tateda K., Yamaguchi K., The Levofloxacin Surveillance Group
  • Organizer: 26th International Congress of Chemotherapy and Infection
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2009-06-20
• [Presentation] 耐性菌への総合戦略～Stop!耐性菌～医療だけではできない!市民、企業、行政からの視点と取り組み. (2009)
  • Author(s): 石井良和
  • Organizer: 第57回日本化学療法学会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-05
• [Presentation] 国産鶏肉由来気基特異性拡張型βラクタマーゼの解析. (2009)
  • Author(s): 江藤麻希, 石井良和, 眞野容子, 原田壮平, 山口惠三
  • Organizer: 第57回日本化学療法学会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-05
• [Presentation] 多剤耐性緑膿菌の耐性因子と抗菌薬併用効果の関連性について. (2009)
  • Author(s): 片岡裕史, 井田孝志, 前橋一紀, 小栗豊子, 石井良和, 舘田一博, 山口惠三
  • Organizer: 第57回日本化学療法学会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-05
• [Presentation] 薬剤耐性菌講座-メカニズムの基本から新知見まで-2.不活化酵素. (2009)
  • Author(s): 石井良和
  • Organizer: 第57回日本化学療法学会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-04
• [Presentation] 呼吸器材料を対象としたLoop-mediated-isothermal amplification法を用いたLegionella属菌による感染症診断に関する検討. (2009)
  • Author(s): 石井良和, 蝶0名林直彦, 中森祥隆, 佐野剛, 本間栄, 松原啓太, 岩田敏, 舘田一博, 山口恵三
  • Organizer: 第57回日本化学療法学会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-04
• [Presentation] Integrating conjugative elementにampCが存在する臨床材料から分離されたProteus mirabilisの解析. (2009)
  • Author(s): 原田壮平, 石井良和, 山口惠三
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-03-12
• [Presentation] Citorobacter属菌が保有するqnrB遺伝子に関する解析. (2009)
  • Author(s): 嵯峨知生, 石井良和, 賀来満夫, 山口惠三
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-03-12
• [Presentation] 抗菌薬で汚染される環境・地球-耐性菌出現のリザーバーとして- (4)環境からの伝播が危惧される耐性菌-臨床分離株の視点から- (2009)
  • Author(s): 石井良和
  • Organizer: 第24回日本環境感染学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-02-28
• [Presentation] SHV-12, DHA-1βラクタマーゼ産生Klebsiella pneumoniaeが分離された1症例~経過中に出現したカルバペネム系耐性菌の機序と臨床背景の検討~. (2009)
  • Author(s): 山田友紀, 石井良和, 畠山裕司, 昆浩, 黒田牧子, 伊東みち子, 野々宮百合子, 山端久美子, 山口惠三, 諏訪部章
  • Organizer: 第20回日本臨床微生物学会
  • Place of Presentation: 仙台
  • Year and Date: 2009-01-31
• [Presentation] 臨床微生物学の今後の展開-新たなコンセプトとテクノロジーの展開- (4)グラム陰性菌の抗菌薬耐性に関する最近の話題-βラクタマーゼを中心として-. (2009)
  • Author(s): 石井良和
  • Organizer: 第20回日本臨床微生物学会(シンポジウム).
  • Place of Presentation: 仙台
  • Year and Date: 2009-01-31
• [Presentation] Isolation Frequency of Extended-Spectrum Beta-Lactamases Producing E.coli, K.pneumoniae or P.mirabilis and Metallo-Beta-Lactamases Producing P.aeruginosa from 72 Centres in Japan, 2007 (2009)
  • Author(s): Ishii Y., Ohno A., Tateda K., Yamaguchi K.
  • Organizer: 26^<th> International Congress of Chemotherapy and Infection
  • Place of Presentation: Toronto, Canada
• [Presentation] 耐性菌への総合戦略～Stop! 耐性菌～医療だけではできない! 市民、企業、行政からの視点と取り組み (2009)
  • Author(s): 石井良和
  • Organizer: 第57回日本化学療法学会
  • Place of Presentation: 東京
• [Presentation] 薬剤耐性菌講座―メカニズムの基本から新知見まで―2. 不活化酵素 (2009)
  • Author(s): 石井良和
  • Organizer: 第57回日本化学療法学会
  • Place of Presentation: 東京
• [Presentation] 抗菌薬で汚染される環境・地球-耐性菌出現のリザーバーとして-(4)環境からの伝播が危惧される耐性菌-臨床分離株の視点から- (2009)
  • Author(s): 石井良和
  • Organizer: 第24回日本環境感染学会(シンポジウム)
  • Place of Presentation: 横浜
• [Presentation] 臨床微生物学の今後の展開-新たなコンセプトとテクノロジーの展開-(4)グラム陰性菌の抗菌薬耐性に関する最近の話題-β-ラクタマーゼを中心として- (2009)
  • Author(s): 石井良和
  • Organizer: 第20回日本臨床微生物学会(シンポジウム)
  • Place of Presentation: 仙台
• [Presentation] Inhibition activity of ME1071, a novel metallo-s-lactamase inhibitor, agaist metallo-s-lactamases. (2008)
  • Author(s): Ishii Y, Kouyama Y, Mano Y. Koh TH. Tateda K, Yamaguchi K.
  • Organizer: 10th s-lactamase Meeting
  • Place of Presentation: (Symposium) Eretria, Greece
  • Year and Date: 2008-06-03
• [Presentation] 感染対策の職員教育を考える〜いつ 誰に 何を どのように 教えるか〜 薬剤師の立場から (2008)
  • Author(s): 石井良和
  • Organizer: 第23回日本環境感染学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2008-02-23
• [Presentation] 緑膿菌が産生するβラクタマーゼの種類とその特徴 (2008)
  • Author(s): 石井良和
  • Organizer: 第42回緑膿菌感染症研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-02-02
• [Presentation] Inhibition activity of ME1071, a novel metallo-β-lactamase inhibitor, against metallo-β-lactamases (2008)
  • Author(s): Ishii Y, Kouyama Y, Mano Y. Koh TH. Tateda K, Yamaguchi K.
  • Organizer: 10th β-lactamase Meeting
  • Place of Presentation: Eretria, Greece
• [Presentation] Shewanella属菌のOXA-型カルバペネマーゼ保有状況に関する検討 (2008)
  • Author(s): 石井良和
  • Organizer: 第81回日本細菌学会
  • Place of Presentation: 京都
• [Presentation] 職種間の連携による感染症の診断と治療(1)感染症診断の後方支援: 薬剤耐性機構の抗菌薬選択に与えるインパクト (2007)
  • Author(s): 石井良和、舘田一博
  • Organizer: 第56回日本感染症学会東日本地方会総会・第54回日本化学療法学会東日本支部総会
  • Place of Presentation: C東京
  • Year and Date: 2007-10-26
• [Presentation] In Vitro Synergistic Effects of Combinations of CP3242(ME1071), as a Novel Metallo-β-Lactamase Inhibitor, and Carbapenems against Carbapenemase Producing Organisms (2007)
  • Author(s): Ishii Y. Tateda K and Yamaguchi K
  • Organizer: 47th Interscience Conference of Antimicrobial Agents and Chemotherapy
  • Place of Presentation: Chicago, USA
  • Year and Date: 2007-09-17
• [Book] 感染症診療の基礎と臨床～耐性菌の制御に向けて～ (2010)
  • Author(s): 石井良和(分担)
  • Total Pages: 12
  • Publisher: 医薬ジャーナル社
• [Book] 先端医学社. わが国の呼吸器感染症主要病原細菌における薬剤耐性の現状はどうなっているか (2009)
  • Author(s): 石井良和, 山口恵三
  • Publisher: 先端医学社
• [Book] 急速に拡散する新規カルバペネマーゼKPC型酵素 (2009)
  • Author(s): 石井良和
  • Publisher: 医歯薬出版
• [Book] 食肉を汚染する抗菌薬耐性菌 (2009)
  • Author(s): 江藤麻希, 石井良和
  • Publisher: 栄研化学
• [Book] 薬剤耐性菌のメカニズム・検出法・疫学基質特異性拡張型βラクタマーゼ(ESBL)産生菌、AmpC型βラクタマーゼ産生菌、メタロ-βラクタマーゼ産生菌. (2009)
  • Author(s): 石井良和
  • Publisher: 近代出版
• [Book] 臨床微生物検査・1 ESBL産生菌 (2008)
  • Author(s): 石井良和
  • Publisher: 医学書院
• [Book] カルバペネム系抗菌薬を使う・使わないの臨床決断 (2008)
  • Author(s): 石井良和
  • Publisher: ヴァンメディカル
• [Book] 緑膿菌感染症研究会記録 42(緑膿菌が産生するβラクタマーゼの種類とその特徴) (2008)
  • Author(s): 石井良和
  • Publisher: 緑膿菌感染症研究会
• [Book] 臨床検査 (2008)
  • Author(s): 石井良和
  • Total Pages: 4
  • Publisher: 医学書院
• [Book] Infection Control 16(ICTみんなで知っておきたい抗菌薬の適正使用Q&A 2.グラム陰性菌の耐性菌はなぜ増えた?) (2007)
  • Author(s): 石井良和
  • Publisher: メディカ出版
• [Book] 日本臨床 65(増刊号2)(【新感染症学 新時代の基礎・臨床研究】VII.抗菌薬 3.薬剤耐性化と対策 ESBLをその産生菌) (2007)
  • Author(s): 石井良和
  • Publisher: 日本臨床社
• [Book] 医学のあゆみ (2007)
  • Author(s): 石井良和
  • Total Pages: 4
  • Publisher: 医歯薬出版株式会社
• [Book] 日本臨床 (2007)
  • Author(s): 石井良和
  • Total Pages: 5
  • Publisher: 株式会社日本臨床社
• [Book] Infection Control (2007)
  • Author(s): 石井良和
  • Total Pages: 6
  • Publisher: メディカ出版
• [Patent(Industrial Property Rights)] オキサ型βラクタマーゼ産生菌の検出方法、同定法及びキット (2009)
  • Inventor(s): 山口惠三 石井良和 舘田一博 神山裕一
  • Industrial Property Rights Holder: 山口惠三 石井良和 舘田一博
  • Industrial Property Number: 2009-012842
  • Filing Date: 2009-01-23
• [Patent(Industrial Property Rights)] 感染症治療効果増強剤 (2008)
  • Inventor(s): 山口惠三 石井良和 舘田一博 青木信将
  • Industrial Property Rights Holder: 山口惠三 石井良和 舘田一博
  • Industrial Property Number: 2008-193644
  • Filing Date: 2008-07-28