| Project/Area Number |
19591196
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
|
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
ISHIKAWA Jun National Institute of Infectious Diseases, 生物活性物質部, 室長 (40202957)
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| Co-Investigator(Kenkyū-buntansha) |
ISHINO Keiko 国立感染症研究所, 生物活性物質部, 主任研究官 (50332359)
HOSHINO Yasutaka 国立感染症研究所, 生物活性物質部, 主任研究官 (40399457)
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| Research Collaborator |
FUJII Shoko 東邦大学, 大学院・理学研究科
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 薬剤耐性 / 抗生物質 / 感染症 / ノカルジア / レジストーム / アミノグリコシド / イソニアジド / 薬剤排出ポンプ / 多剤耐性 / トランスポーター / リファンピシン / Nocardia / モノオキシゲナーゼ / クロラムフェニコール / APH / アミノ配糖体 |
|---|
| Research Abstract |
Nocardia is a species of soil actinomycetes and an opportunistic pathogen caused nocadiosis on human or animal. Treatment of nocardiosis is difficult because of the multi-drug resistant profile of Nocardia. However, the mechanisms of the resistance have not been studied with a few exceptions. We demonstrated the resistance mechanisms for rifampicin, aminoglycosides, and chloramphenicol as part of deciphering all the resistance mechanisms (resistome) of N.farcinica.
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