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Analysis of HB-EGF on the pathogenesis of psoriasis using tetracycline-inducible transgenic mice system.

Research Project

Project/Area Number 19591311
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionEhime University

Principal Investigator

SHIRAKATA Yuji  Ehime University, 大学院・医学系研究科, 講師 (50226320)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords尋常性乾癬 / 遺伝子誘導 / HB-EGF / Amphiregulin / Tet-on / TG mouse / 乾癬
Research Abstract

本研究は、活性化STAT3 が乾癬病変の形成に重要な役割を果たすことから、STAT3 を活性化するEGF family の機能を明らかにすることにある。表皮において重要であるEGF Family のHB-EGFとAmphiregulin の遊離型と膜型の遺伝子誘導マウスをそれぞれ開発し、乾癬のモデルマウスとして有用か否かについて検討した。これらのマウスにドキシサイクリンを投与し、自然発症乾癬モデルマウスとなり得るか現在観察中である。また、創傷刺激を与えて乾癬病変が誘導できるか否かについての実験を準備中である。

Report

(2 results)
  • 2008 Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (23 results)

All 2008 2007 2000

All Journal Article (18 results) (of which Peer Reviewed: 8 results) Presentation (5 results)

  • [Journal Article] PPARgamma is an important transcription factor in 1alpha,25-dihydroxyvitamin D3-induced involucrin expression2008

    • Author(s)
      Dai X, Sayama K, Shirakata Y, Tokumaru S, Yang L, Tohyama M, Hirakawa S, Hanakawa Y, Hashimoto K
    • Journal Title

      J Dermatol Sci 50

      Pages: 53-60

    • Related Report
      2008 Final Research Report
  • [Journal Article] The NF-kB, p38 MAPK and STAT1 pathways differentially regulate the dsRNA-mediated innate immune responses of epidermal keratinocytes2008

    • Author(s)
      Dai X, Sayama K, Tohyama M, Shirakata Y, Yang L, Hirakawa S, Tokumaru S, Hashimoto K
    • Journal Title

      Int Immunol 20

      Pages: 901-9

    • Related Report
      2008 Final Research Report
  • [Journal Article] A marked increase in serum soluble Fas ligand in drug-induced hypersensitivity syndrome2008

    • Author(s)
      Tohyama M, Shirakata Y, Sayama K, Hashimoto K
    • Journal Title

      Br J Dermatol 159

      Pages: 981-4

    • Related Report
      2008 Final Research Report
  • [Journal Article] An intermediary role of proHB-EGF shedding in growth factor-induced c-Myc gene expression2008

    • Author(s)
      Nanba D, Inoue H, Shigemi Y, Shirakata Y, Hashimoto K, Higashiyama S
    • Journal Title

      J Cell Physiol. 214

      Pages: 465-73

    • Related Report
      2008 Final Research Report
  • [Journal Article] An interme role of proHB-EGF shedding in growth factor-induced c-Myc gene expression2008

    • Author(s)
      Nanba D, Inoue H, Shigerni Y, Shirakata Y, et. al.
    • Journal Title

      J Cell Physiol 214

      Pages: 465-73

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PPARgamma is an important transcription factor in lalpha, 25-dihydroxyvitamin D3-induced in voilucrin expression2008

    • Author(s)
      Dai X, Sayama K, Shirakata Y, et. al.
    • Journal Title

      J Drematol Sci 50

      Pages: 53-60

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epiregulin, a member of the EGF family, is over-expressed in psoriatic epidermis2007

    • Author(s)
      Shirakata Y, Kishimoto J, Tokumaru S, Yamasaki K, Hanakawa Y, Tohyama M, Sayama K, Hashimoto K
    • Journal Title

      J Dermatol Sci 45

      Pages: 69-72

    • NAID

      10019994988

    • Related Report
      2008 Final Research Report
  • [Journal Article] Hair follicle regeneration using grafted rodent and human cells2007

    • Author(s)
      Ehama R, Ishimatsu-Tsuji Y, Iriyama S, Ideta R, Soma T, Yano K, Kawasaki C, Suzuki S, Shirakata Y, Hashimoto K, Kishimoto J
    • Journal Title

      J Invest Dermatol 127(9)

      Pages: 2106-15

    • Related Report
      2008 Final Research Report
  • [Journal Article] STAT5a/PPARgamma Pathway Regulates Involucrin Expression in Keratinocyte Differentiation2007

    • Author(s)
      Dai X, Sayama K, Shirakata Y, Hanakawa Y, Yamasaki K, Tokumaru S, Yang L, Wang X, Hirakawa S, Tohyama M, Yamauchi T, Takashi K, Kagechika H, Hashimoto K
    • Journal Title

      J Invest Dermatol 127(7)

      Pages: 1728-35

    • Related Report
      2008 Final Research Report
  • [Journal Article] CXCL16 is a novel mediator of the innate immunity of epidermal keratinocytes2007

    • Author(s)
      Tohyama M, Sayama K, Komatsuzawa H, Hanakawa Y, Shirakata Y, Dai X, Yang L, Tokumaru S, Nagai H, Hirakawa S, Sugai M, Hashimoto K
    • Journal Title

      Int Immunol 19

      Pages: 1095-1102

    • NAID

      10020108093

    • Related Report
      2008 Final Research Report
  • [Journal Article] Human corneal epithelial cell proliferation by epiregulin and its cross-induction by other EGF family members2007

    • Author(s)
      Morita S, Shirakata Y, Shiraishi A, Kadota Y, Hashimoto K, Higashiyama S, Ohashi Y
    • Journal Title

      Molecular Vision 13

      Pages: 2119-2128

    • Related Report
      2008 Final Research Report
  • [Journal Article] Human corneal epithelial cell proliferation by epiregulin and its cross-induction by other EGF family members2007

    • Author(s)
      Morita S, Shirakata Y, et. al.
    • Journal Title

      Molecular Vision 13

      Pages: 2119-2128

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epiregulin,a member of the EGF family,is over-expressed in psoriatic epidermis2007

    • Author(s)
      Shirakata Y, Kishimoto J, et. al.
    • Journal Title

      J Dermatol Sci 45

      Pages: 69-72

    • NAID

      10019994988

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hair follicle regeneration using grafted rodent and human cells2007

    • Author(s)
      Ehama R, Ishimatsu-Tsuji Y, Iriyama S, Ideta R, Soma T, Yano K, Kawasaki C, Suzuki S, Shirakata Y, et. al.
    • Journal Title

      J Invest Dermatol 127

      Pages: 2106-15

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] STAT5a/PPARgamma Pathway Regulates Involucrin Expression Keratinocyte Differentiation2007

    • Author(s)
      Dai X, Sayama K, Shirakata Y, et. al.
    • Journal Title

      J Invest Dermatol 127

      Pages: 1728-35

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressor of cytokine signaling 3 negative regulation of signal transducer and activator of transcription 3 in platelet-derived growth factor-induced fibroblast migration2007

    • Author(s)
      Nagai H, Tokumaru S, Sayama K, Shira kata Y, et. al.
    • Journal Title

      J Dermatol 34

      Pages: 523-530

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CXCLl6 is a novel mediator of the innate immunity of epidermal keratinocytes2007

    • Author(s)
      Tohyama M, Sayama K, Komatsuzawa H, Hanakawa Y, Shirakata Y, et. al.
    • Journal Title

      Int Immunol 19

      Pages: 1095-1102

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressor of cytokine signaling 3 negative regulation of signal transducer and activator of transcription 3 in platelet-derived growth factor-induced fibroblast migration2000

    • Author(s)
      Nagai H, Tokumaru S, Sayama K, Shirakata Y, Hanakawa Y, Hirakawa S, Dai X, Tohyama M, Yang L, Hashimoto K
    • Journal Title

      J Dermatol 34

      Pages: 523-530

    • NAID

      10021306180

    • Related Report
      2008 Final Research Report
  • [Presentation] Keratinocyte-specific SOCS3 knockout mice show clinical phenotypes similar to human psoriasis2008

    • Author(s)
      Shirakata Y, Yang L, et.al.
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      Kyoto
    • Related Report
      2008 Final Research Report
  • [Presentation] A new skin equivalent using de-epithelialized amnion membrane2007

    • Author(s)
      Shirakata Y, Yang L, Hashimoto K
    • Organizer
      8^<th> Congress of the German-Japanese Society of Dermatology
    • Place of Presentation
      Yokohama
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] PPAR-gamma is involved in 1.25-dihydroxyvitamin D3-induced beta-defensin-3 and cathelicidin expression in normal keratinocyte2007

    • Author(s)
      Dai X, Shirakata Y, et.al.
    • Organizer
      68^<th> Annual Meeting of the Society for Investigative Dermatology
    • Place of Presentation
      Los Angeles
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Development of a new skin equivalent model using de-epithelialized amnion membrane2007

    • Author(s)
      Yang L, Shirakata Y et.al.
    • Organizer
      68^<th> Annual Meeting of the Society for Investigative Dermatology
    • Place of Presentation
      Los Angeles
    • Related Report
      2008 Final Research Report
  • [Presentation] Development of a new skin equivalent model using de-epithelialized amnion memtmebrance2007

    • Author(s)
      Yang L, Shirakata Y, et. al.
    • Organizer
      68^<th> Annual Meeting of the Society for Investigative Dermatology
    • Place of Presentation
      Los Angeles
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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