| Project/Area Number |
19591366
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
KONDO Tsuyoshi University of the Ryukyus, 医学研究科, 教授 (40215455)
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| Co-Investigator(Kenkyū-buntansha) |
MIHARA Kazuo 国立大学法人琉球大学, 医学部, 准教授 (30302029)
NAKAMURA AKifumi 国立大学法人琉球大学, 医学部附属病院, 助教 (40381222)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | うつ病性障害 / 気質性格因子 / 遺伝多型 / 抗うつ薬 / 気分安定薬 / 自殺関連事象 / 病前気質 / TEMPS-A/MPT / soft bipolarity / 循環気質 / aripiprazole / CYP2D6 / *10アレル / genotyping / lamotrigine / 治療抵抗性うつ病 / MADRS / GAF / 思春期症例 / 治療前危険因子 / paroxetine / mianserin / SASS / TCI / 治療脱落例 / 治療反応性 / うつ病 / ドーパミン受容体 / TaqI A遺伝子多型 / -141 Del / Ins遺伝子多型 / 抗精神病薬 / セロトニン / ノルアドレナリン |
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| Research Abstract |
Genetic and biological markers to achieve efficient individualized pharmacotherapy of depressive disorders were investigated. Young females had higher scores in cyclothymic temperament, suggesting potential risk of antidepressant-induced mood switching in these subjects. Gene-dose effect of ^*10 allele of cytochrome P450 2D6 was apparent in the steady-state concentrations of aripiprazole. Lamotrigine augmentation in patients with treatment-resistant mood disorders resulted in reduced severity of depressive symptoms (-41.9%) and increased social functioning (+30.3%), showing better response especially in subjects with a shorter and frequent depressive episodes. Persisted suicide-related risks among teenagers under antidepressant therapy were closely associated with some clinical backgrounds (over 15 years of age, female and baseline self-destructive behaviors) and specific psychopathology (anhedonia, irritability, hopelessness, borderline personality disorder and psychotic features).
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