Asbestos related pleural malignant mesothelioma-18F-FDG PET/CT findings-

• Project/Area Number: 19591440
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kurume University
• Principal Investigator: KURATA Seiji Kurume University, 医学部, 助教 (80268888)
• Co-Investigator(Kenkyū-buntansha): KAIDA Hayato 久留米大学, 医学部, 助教 (40299425) ; ISHIBASHI Masatoshi 久留米大学, 医学部, 教授 (20168256) ; HAYABUCHI Naofumi 久留米大学, 医学部, 教授 (20108731) ; TAKAMORI Shinzo 久留米大学, 医学部, 准教授 (50197208) ; AIZAWA Hisamichi 久留米大学, 医学部, 教授 (90175711)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: PET / CT / アスベスト / 悪性胸膜中皮腫 / 画像診断学 / 悪陸胸膜中皮腫

Research Abstract

Analysis of 18F-FDG PET/CT and plasma osteopontin levels were performed in asbestos-related pleural disease patients. Six patients had histologically proven malignant pleural mesothelioma (MPM). In 11 patients, the disease was considered benign pleural disease. Four patients had proven asbestos pleurisy. The remaining 7 patients had proven pleural plaques. Significant differences were found among the three groups of asbestos-related pleural diseases for the plasma osteopontin levels and the SUVmax. Significant differences in the SUVmax were found between patients with MPM and those with asbestos pleurisy and between patients with MPM and patients with pleural plaques. However, there was no significant difference in the plasma osteopontin levels between patients with MPM and patients with asbestos pleurisy or between patients with MPM and patients with pleural plaques. The SUVmax in patients with benign asbestos-related diseases correlated well with plasma osteopontin levels in the same group, but the SUVmax in patients with MPM did not correlate with plasma osteopontin levels in the same group. PET/CT might be more helpful in distinguishing benign asbestos-related pleural diseases from MPM than plasma osteopontin, and the SUVmax in benign asbestos-related pleural diseases may reflect changes in pleural inflammation.

Research Products

• [Journal Article] Prognostic value of SUVmax measurements obtained by FDG-PET in patients with non-small cell lung cancer receiving chemotherapy. (2010)
  • Author(s): Yohei Imamura, Koichi Azuma, Seiji Kurata, Satoshi Hattori, Tetsuro Sasada, Takashi Kinoshita, Masaki Okamoto, Tomotaka Kawayama, Hayato Kaida, Masatoshi Ishibashi, Hisamichi Aizawa.
  • Journal Title: Lung Cancer. (in press)
• [Journal Article] Preliminary study of PET/CT and plasma osteopontin levels in patients with asbestos-related pleural disease Jpn J Radiol (2010)
  • Author(s): Seiji Kurata, Masatoshi Ishibashi, Koichi Azuma, Hayato Kaida, Shinzo Takamori, Kiminori Fujimoto, Maiko Kobayashi, Yasumitsu Hirose, Hisamichi Aizawa, Naofumi Hayabuchi
  • Journal Title: (in press)
• [Journal Article] Masatoshi Ishibashi Mastopathic-type fibroadenoma and ductal adenoma of the breast with false-positive flurodeoxyglucose positron emission tomography Jpn J Radiol (2009)
  • Author(s): Rin Yamaguchi, Yasuhiko Futamata, Fumihiro Yoshimura, Naotaka Murakami, Kikuo Koufuji, Rumiko Kutani, Kazuyuki Kojima, Shino Ohki, Seiji Kurata, Hayato Kaida
  • Journal Title: 27 Pages: 280-284
• [Journal Article] Improved breast cancer detection of prone breast fluorodeoxyglucose-PET in 118 patients Nuclear Medicine Communications (2008)
  • Author(s): Hayato Kaida, Masatoshi Ishibashi, Teruhiko Fujii, Seiji Kurata, Masafumi Uchida, Kenkichi Baba, Teruo Miyagawa, Hiroko Kaibara, Seiji Kawamura, Etsuyo Ogo, Naofumi Hayabuchi.
  • Journal Title: 29(10) Pages: 885-893
• [Journal Article] Masafumi Uchida, Naofumi Hayabuchi Diffuse and diffuse-plus-focal uptake in the thyroid gland identified by using FDG-PET: prevalence of thyroid cancer and Hashimoto's thyroiditis. (2007)
  • Author(s): Seiji Kurata, Masatoshi Ishibashi, Yuji Hiromatsu, Hayato Kaida, Ikyo Miyake
  • Journal Title: Annals of Nuclear Medicine 21 Pages: 325-330
• [Presentation] Naofumi Hayabuchi Clinical assessment of 18F-FDG PET/CT and plasma osteopontin levels in patients with asbestos-related pleural disease Annual Congress of the European Association of Nuclear Medicine 2009 (2009)
  • Author(s): Seiji Kurata, Masatoshi Ishibashi, Hayato Kaida, Koichi Azuma, Maiko Kobayashi, Yasumitsu Hirose, Shinzo Takamori, Kiminori Fujimoto, Hisamichi Aizawa
  • Place of Presentation: Barcelona, Spain
• [Presentation] Naofumi Hayabuchi Staging of mediastinal and hilar lymph node metastases from nonsmall cell lung cancer:comparison of diagnosis accuracy of MRI and FDG-PET 13th World Conference on Lung Cancer (2009)
  • Author(s): Kiminori Fujimoto, Hayato Kaida, Nestor L. Muller, Junko Sadohara, Ryouji Iwamoto, Naoko Fujimoto, Seiji Kurata, Fumihiko Muta, Toshihiro Matsuo, Shinzo Takamori, Masatoshi Ishibashi
  • Place of Presentation: San Francisco, U.S. A
• [Presentation] Clinical assessment of 18F-FDG PET/CT and plasma osteopontin levels in patients with asbestos-related pleural disease (2009)
  • Author(s): Seiji Kurata, Masatoshi Ishibashi, Hayato Kaida, Koichi Azuma, Maiko Kobayashi, Yasumitsu Hirose, Shinzo Takamori, Kiminori Fujimoto, Hisamichi Aizawa, Naofumi Hayabuchi
  • Organizer: Annual Congress of the European Association of Nuclear Medicine
  • Place of Presentation: Barcelona, Spain
• [Presentation] 治療効果判定におけるFDG-PETとGa67シンチグラフィの比較 (2008)
  • Author(s): 倉田精二, 石橋正敏, 甲斐田勇人, 小林真衣子, 貝原紘子, 田原宣広, 溝口ミノリ, 早渕尚文筋サルコイドーシス
  • Organizer: 第48回日本核医学会学術総会
  • Place of Presentation: 幕張メッセ
• [Presentation] FDG-PETと分子病理学的手法を用いての甲状腺乳頭癌の細胞増殖能の特性解析 (2008)
  • Author(s): 甲斐田勇人, 石橋正敏, 倉田精二, 小林真衣子, 貝原紘子, 早渕尚文, 広松雄治, 三橋拓之, 梅野博仁, 中島格, 河原明彦, 鹿毛政義
  • Organizer: 第48回日本核医学会学術総会
  • Place of Presentation: 幕張メッセ
• [Presentation] Diffuse or combined uptake in the thyroid gland as an incidental finding in FDG-PET (2007)
  • Author(s): Seiji Kurata, Masatoshi Ishibashi, Hayato Kaida, Yuji Hiromatsu, Ikuyo Miyake, Naofumi Hayabuchi.
  • Organizer: Risks of thyroid cancer and subclinical hypothyroidism associated with Hashimoto's thyroiditis Society of Nuclear Medicine 2007 Annual Meeting
  • Place of Presentation: Washington, D.C.