| Project/Area Number |
19591475
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SHIGEMATSU Kunihiro (2008-2009) The University of Tokyo, 医学部附属病院, 特任講師 (20215966)
出口 順夫 (2007) The University of Tokyo, 医学部・附属病院, 助教 (50242053)
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| Co-Investigator(Kenkyū-buntansha) |
MIYATA Tetsuro 東京大学, 医学部附属病院, 准教授 (70190791)
KOYAMA Hiroyuki 東京大学, 医学部附属病院, 客員准教授 (10241994)
OKAMOTO Hiroyuki 東京大学, 医学部附属病院, 助教 (60348266)
KIMURA Hideo 東京大学, 医学部附属病院, 助教 (60327070)
FUKAYAMA Masahisa 東京大学, 医学部附属病院, 教授 (70281293)
重松 邦広 東京大学, 医学部附属病院, 助教 (20215966)
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 血管外科学 / 腹部大動脈瘤 / 加齢変化 / コラーゲン線維 / 腹部大動脈 / コラーゲン線維束 |
|---|
| Research Abstract |
The structure of adventitial collagen fiber of abdominal aorta is immature around the inferior mesenteric artery and the direction of the media l collagen fiber becomes more identical in proportion to the age. In patients with abdominal aortic aneurysm, additionally, the collagen density is remarkably decreasing. However, differently from the normal aorta, the direction of medial collagen was scattered and the type I collagen decreases in volume in AAA patients. These data suggest that AAA formation does not depend on the site specificity and aging but also other factors.
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