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Structural analysis of collagen fiber of arterial wall in patients with abdominal aortic aneurysm

Research Project

Project/Area Number 19591475
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionThe University of Tokyo

Principal Investigator

SHIGEMATSU Kunihiro (2008-2009)  The University of Tokyo, 医学部附属病院, 特任講師 (20215966)

出口 順夫 (2007)  The University of Tokyo, 医学部・附属病院, 助教 (50242053)

Co-Investigator(Kenkyū-buntansha) MIYATA Tetsuro  東京大学, 医学部附属病院, 准教授 (70190791)
KOYAMA Hiroyuki  東京大学, 医学部附属病院, 客員准教授 (10241994)
OKAMOTO Hiroyuki  東京大学, 医学部附属病院, 助教 (60348266)
KIMURA Hideo  東京大学, 医学部附属病院, 助教 (60327070)
FUKAYAMA Masahisa  東京大学, 医学部附属病院, 教授 (70281293)
重松 邦広  東京大学, 医学部附属病院, 助教 (20215966)
Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords血管外科学 / 腹部大動脈瘤 / 加齢変化 / コラーゲン線維 / 腹部大動脈 / コラーゲン線維束
Research Abstract

The structure of adventitial collagen fiber of abdominal aorta is immature around the inferior mesenteric artery and the direction of the media l collagen fiber becomes more identical in proportion to the age. In patients with abdominal aortic aneurysm, additionally, the collagen density is remarkably decreasing. However, differently from the normal aorta, the direction of medial collagen was scattered and the type I collagen decreases in volume in AAA patients. These data suggest that AAA formation does not depend on the site specificity and aging but also other factors.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (12 results)

All 2009 2008 2007

All Journal Article (9 results) (of which Peer Reviewed: 5 results) Presentation (3 results)

  • [Journal Article] True abdominal aortic aneurysm in Marfan syndrome2009

    • Author(s)
      Takayama T, Miyata T, Nagawa H
    • Journal Title

      J Vasc Surg 49

      Pages: 1162-1165

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] True abdominal aortic aneurysm in Marfan syndrome2009

    • Author(s)
      Takayama T, Miyata T, et al
    • Journal Title

      Journal of Vascular Surgery 49

      Pages: 1162-1165

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aneurysm of gastroepiploic artery and vein with an arteriove nous fistula after partial gastrectomy in a patient with abdominal aortic aneurysm2008

    • Author(s)
      Shigematsu K et al.
    • Journal Title

      Annals of Vascular Disease 1

      Pages: 52-55

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 大動脈瘤2008

    • Author(s)
      重松邦広、宮田哲郎
    • Journal Title

      内科 101

      Pages: 1312-1315

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Isolated spontaneous dissection of the splanchnic arteries.2008

    • Author(s)
      Takayama T, Miyata T et al.
    • Journal Title

      Journal of Vascular Surgery 48

      Pages: 329-333

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血管壁硬化のさまざまな評価法2007

    • Author(s)
      宮田哲郎
    • Journal Title

      Mebio 24(11)

      Pages: 56-62

    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Journal Article] MMP-13/collagenase-3 の動脈硬化プラークにおける役割2007

    • Author(s)
      出口順夫, 相川真範, 宮田哲郎
    • Journal Title

      脈管学 47(3)

      Pages: 327-331

    • NAID

      10019739333

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The high prevalence of colorectal neoplasms in preoperative patients with abdominal aortic aneurysm or peripheral artery disease.2007

    • Author(s)
      Yamamoto K, Miyata T, Nagawa H
    • Journal Title

      European Journal of Vascular and Endovascular Surgery 33

      Pages: 397-400

    • Related Report
      2007 Annual Research Report
  • [Journal Article] MMP-13/collagenase-3の動脈硬化プラークにおける役割2007

    • Author(s)
      出口順夫、相川真範、宮田哲郎
    • Journal Title

      脈管学 47(3)

      Pages: 327-331

    • NAID

      10019739333

    • Related Report
      2007 Annual Research Report
  • [Presentation] 腹部大動脈瘤手術-腹部手術既往から見た外科治療困難例は?2008

    • Author(s)
      重松邦広
    • Organizer
      日本血管外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 加齢によるヒト正常大動脈・腸骨動脈壁の構造変化についての検討2007

    • Author(s)
      浦部豪, 出口順夫, 橋本拓弥, 高山利夫, 永吉実紀子, 高澤豊, 深山正久, 西蔭誠二, 木村秀生, 重松邦広, 宮田哲郎, 名川弘一
    • Organizer
      第48回日本脈管学会
    • Place of Presentation
      松本
    • Year and Date
      2007-10-25
    • Related Report
      2009 Final Research Report
  • [Presentation] 増大傾向を示す腹部大動脈瘤の立体構造変化の検討2007

    • Author(s)
      浦部豪, 橋本拓弥, 高山利夫, 永吉実紀子, 赤木大輔, 西蔭誠二, 木村秀生, 出口順夫, 重松邦広, 宮田哲郎
    • Organizer
      第35回日本血管外科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-05-25
    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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