Establishment of intensive care for immunologic tolerance of small bowel transplantation in rat
| Project/Area Number |
19591497
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nihon University |
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Principal Investigator |
SUGITO Kiminobu Nihon University, 医学部, 助教 (10328750)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Taro 日本大学, 医学部, 助教 (00318396)
KUSAFUKA Takeshi 日本大学, 医学部, 教授 (70263267)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 移植外科学 / 小腸移植 / 拒絶反応制御 |
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| Research Abstract |
We studied the effect of the combined treatment with FK506, FTY720, and ex vivo graft irradiation. FK506 and FTY720 prevented the infiltration of CD4 positive cells, the down-regulation of MAdCAM-1 expression on HEVs in PPs, and the up-regulation of MAdCAM-1 expression on ECVs in LP during the early phase of SBT.
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Report
(6 results)
Research Products
(29 results)
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[Journal Article] Effect of combined treatment with FK506, FTY720, and ex vivo graft irradiation in rat small bowel transplantation : expression of mucosal addressin cell adhesion molecule-1.2010
Author(s)
Sugito K, Uekusa S, Kawashima H, Masuko T, Furuya T, Konuma N, Ohashi K, Inoue M, Ikeda T, Koshinaga T
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Journal Title
Pediatr Transplant. 14
Pages: 614-7
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Peer Reviewed
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[Presentation] マウスES細胞を用いた腸管組織再生の可能性2008
Author(s)
小沼憲祥,益子貴行,井上幹也,杉藤公信,池田太郎,萩原紀嗣,若林久実子,松本太郎,麦島秀雄,越永従道,草深竹志
Organizer
第20回日本小腸移植研究会
Place of Presentation
大阪
Year and Date
2008-03-01
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