| Project/Area Number |
19591686
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyushu University |
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Principal Investigator |
SHONO Tadahisa Kyushu University, 医学研究院, 准教授 (00346793)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMOTO Koji 九州大学, 大学病院, 講師 (70444784)
MATSUMOTO Kenichi 九州大学, 大学病院, 研究員 (80423581)
AMANO Toshiyuki 九州大学, 大学病院, 助教 (70448413)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | Sox4 / 髄芽種 / グリオーマ / アポトーシス / 神経分化 / 髄芽腫 / 神経幹細胞 / 細胞分化 / 細胞増殖 / ニユーロン / real time PCR / 髓芽腫 / 免疫染色 |
|---|
| Research Abstract |
We analyzed the expression of Sox4 mRNA in various brain tumor samples obtained by surgical resection or tumor cell lines using real-time PCR analysis. We found that the expression levels of Sox4 mRNA in medulloblastomas are especially increased among these brain tumors. When we transfer Sox4 gene into malignant glioma cell lines, the cell growth was strongly enhanced. Conversely, when we transfer Sox4 gene into medulloblastoma cell lines, there was no significant change in cell growth.
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