Expression of SOX4 gene and its roles in medulloblastoma
| Project/Area Number |
19591686
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyushu University |
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Principal Investigator |
SHONO Tadahisa Kyushu University, 医学研究院, 准教授 (00346793)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMOTO Koji 九州大学, 大学病院, 講師 (70444784)
MATSUMOTO Kenichi 九州大学, 大学病院, 研究員 (80423581)
AMANO Toshiyuki 九州大学, 大学病院, 助教 (70448413)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | Sox4 / 髄芽種 / グリオーマ / アポトーシス / 神経分化 / 髄芽腫 / 神経幹細胞 / 細胞分化 / 細胞増殖 / ニユーロン / real time PCR / 髓芽腫 / 免疫染色 |
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| Research Abstract |
We analyzed the expression of Sox4 mRNA in various brain tumor samples obtained by surgical resection or tumor cell lines using real-time PCR analysis. We found that the expression levels of Sox4 mRNA in medulloblastomas are especially increased among these brain tumors. When we transfer Sox4 gene into malignant glioma cell lines, the cell growth was strongly enhanced. Conversely, when we transfer Sox4 gene into medulloblastoma cell lines, there was no significant change in cell growth.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Prevalence of copy number neutral LOH in glioblastomas revealed by genome-wide analysis of laser-microdissected tissues.2008
Author(s)
Kuga D, Mizoguchi M, Guan Y, Hata N, Yoshimoto K, Shono T, Suzuki SO, Kukita Y, Tahira T, Nagata S, Sasaki T, Hayashi K
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Journal Title
Neuo-Oncol 10
Pages: 995-1003
Related Report
Peer Reviewed
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[Journal Article] Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival.2008
Author(s)
Shono T, Yokoyama N, Uesaka T, Kuroda J, Takeya R, Yamasaki T, Amano T, Mizoguchi M, Suzuki SO, Niiro H, Miyamoto K, Akashi K, Iwaki T, Sumimoto H, Sasaki T
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Journal Title
Int J Cancer 123
Pages: 787-792
Related Report
Peer Reviewed
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[Journal Article] Narrowing of the regions of allelic losses of chromosome 1p36 in meningioma tissues by an improved SSCP analysis.2008
Author(s)
Guan Y, Hata N, Kuga D, Yoshimoto K, Mizoguchi M, Shono T, Suzuki SO, Tahira T, Kukita Y, Hisaga K, Yokoyama N, Nagata S, Iwaki T, Sasaki T, Hayashi K
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Journal Title
Int J Cancer 122
Pages: 1820-1826
Related Report
Peer Reviewed
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[Journal Article] Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity.2007
Author(s)
Uesaka T, Shono T, Kuga D, Suzuki SO, Niiro H, Miyamoto K, Matsumoto K, Mizoguchi M, Ohta M, Iwaki T, Sasaki T
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Journal Title
J Neurooncol 84
Pages: 119-129
Related Report
Peer Reviewed
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