The mechanism of neuroprotective effect of anesthetics related to MAP kinases and calcium
| Project/Area Number |
19591790
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Osaka University |
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Principal Investigator |
SHIBUTA Satoshi (SATOSHI Shibuta) Osaka University, 医学系研究科, 助教 (20324767)
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| Co-Investigator(Kenkyū-buntansha) |
MASHIMO Takashi 大阪大学, 大学院・医学研究科, 教授 (10110785)
KAMIBAYASHI Takahiko 大阪大学, 大学院・医学研究科, 助教 (10273640)
真下 節 大阪大学, 医学系研究科, 教授 (60157188)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | MAPキナーゼ / カルシウム / 麻酔薬 / 一酸化窒素 / 神経保護作用 / 温度 / 低酸素性脳傷害 / 神経細胞 / 初代培養 / フリーラジカルスカベンジャー / 低温 / 麻酔 / 神経保護 / NMDA受容体 / 高温 / フリーラジカル / スカベンジ / 大脳皮質 / 培養細胞 / 静脈麻酔薬 / ケタミン / チオペンタールナトリウム |
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| Research Abstract |
Edaravone, a free radical scavenger, has been shown to be neuroprotective in in vivo and in vitro conditions. However, the impact of small temperature variations on the molecule remains unknown. Our study found that the temperature of the CNS is a potential factor in determining whether edaravone confers a potent neuroprotective effect when applied during prolonged hypoxic insults.
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Report
(6 results)
Research Products
(21 results)
