Evaluation for action mechanism of Alpha2-agonist dexmedetomidine to respiratory center in medulla
| Project/Area Number |
19591821
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nippon Medical School |
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Principal Investigator |
TAKEDA Shinhiro Nippon Medical School, 医学部, 准教授 (00247008)
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| Co-Investigator(Kenkyū-buntansha) |
KIM Chol 日本医科大学, 医学部, 講師 (80318493)
赤田 信二 日本医科大学, 医学部, 助教 (50366720)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 呼吸中枢 / デクスメデトミジン / 呼吸性ニューロン |
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| Research Abstract |
I administer dexmedetomidine which is the experimental group of this study and, with a rat brainstem spinal cord preparation, investigate the activity of the respiratory center. It is perfusion in the artificial cerebrospinal fluid which the specimen rises to perfusion tank, and was saturated with 95%O_2, 5% CO_2. As a breathing of the respiratory neuron activity output monitor, it is recorded inspiratory activity with an absorption electrode by a C4 ventral root. I administer dexmedetomidine in perfusion liquid and record the activity characteristics output of the breathing when respiratory depression and a breathing change occur-related neuron continually. As for the result, respiratory neuron activity was depressed dose-dependency by dexmedetomidine. However, the clear influence was not recognized in activity characteristics of the respiratory neuron by the general clinical use density. As for the restraint of the breathing in the high density-related neuron activity, indirect influence by the stimulation of the alpha-adrenoreceptor was suggested, and it seemed that there was little direct influence of dexmedetomidine to the respiratory neuron in the medulla.
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Report
(4 results)
Research Products
(8 results)
