| Project/Area Number |
19591885
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kitasato University |
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Principal Investigator |
YOSHIDA Kazunari Kitasato University, 医学部, 准教授 (10174921)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKEUCHI Yasuo 北里大学, 医学部, 講師 (60286359)
OISHI Masamichi 北里大学, 理学部, 講師 (40233027)
KODERA Yoshio 北里大学, 理学部, 准教授 (60265733)
BABA Shiro 北里大学, 医学部, 教授 (00051889)
OKUSA Hiroshi 北里大学, 医学部, 助教 (70337963)
MAEDA Tadakazu 北里大学, 理学部, 教授 (90265728)
MURAMOTO Masatoshi 北里大学, 医学部, 助教 (50265633)
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|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 腎移植 / 血中抗体 / プロテオーム解析 / プロテーオム解析 |
|---|
| Research Abstract |
The rejection is the most serious problem in renal transplantation, but there is no clear clinical marker to diagnose at an early stage. In this study, we developed the effective pretreatment method of urine followed by proteor is analysis using agarose two-dimensional electrophoresis. With this method, we detected eight rejection-associated proteins and identified them by LC-MS/MS analysis.
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