Study on the mechanisms of human placental trophoblast syncytialisation : implication for the pathogenesis of pre-eclampsia
| Project/Area Number |
19591895
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Hiroshima University |
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Principal Investigator |
KUDO Yoshiki Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (80241082)
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| Co-Investigator(Kenkyū-buntansha) |
MIYOSHI Hiroshi 広島大学, 大学院・医歯薬学総合研究科, 講師 (40294590)
NOBUZANE Takahiro 広島大学, 病院, 助教 (80403559)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 胎盤 / トロフォブラスト / 妊娠高血圧症候群 |
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| Research Abstract |
We have demonstrated that CD98 surface antigen, syncytin, an envelope gene of HERV-W (human endogenous retrovirus-W), and its receptor type D mammalian retrovirus receptor (ASCT2) are involved in the process of cell fusion necessary for syncytiotrophoblast formation using a cell model of syncytialisation (the cytotrophoblast cell line BeWo following increased intracellular cAMP by forskolin treatment).
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Report
(4 results)
Research Products
(25 results)
