Development of the new treatment strategy for cancer using the transgenic mice that induced the epithelial tumors

• Project/Area Number: 19591927
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Kawasaki Medical School (2008-2009); University of Toyama (2007)
• Principal Investigator: NAKAMURA Takafumi Kawasaki Medical School, 医学部, 教授 (20303969)
• Co-Investigator(Kenkyū-buntansha): SAITO Shigeru 富山大学, 大学院・医学薬学研究部, (医学)教授 (30175351) ; YAMAMOTO Hiroshi 富山大学, 生命科学先端研究センター, 准教授 (00108797)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: SV40T抗原 / トランスジェニックマウス / 水晶体腫瘍 / 自然免疫マクロファージ / NK細胞 / 漢方薬 / 自然免疫 / マクロファージ / 十全大補湯 / 補中益気湯 / 小柴胡湯 / p53 / pRB

Research Abstract

Herbal medicine (Juzentaihoto, Hochuekkito) extended duration of life of cancer bearing laboratory mouse significantly. These herbal medicine are able to activate natural immunity, and there would be a possibility that the immunology of cancer bearing laboratory mouse might be activated.

Research Products

• [Journal Article] SV40 T antigen disrupted the cell metabolism and the balance between proliferation and apoptosis in lens tumors of transgenic mice. (2009)
  • Author(s): Zheng HC., Nakamura T., Zheng Y., Nakanishi Y., Tabuchi Y., Uchiyama A., Takahashi H., Takano Y.
  • Journal Title: J Cancer Res Clin Oncol. 135 Pages: 1521-1532
• [Journal Article] Herbal medicine Shakuyaku-kanzo-to reduces Paclitaxel-induced painful peripheral neuropathy in mice Saito S. (2009)
  • Author(s): Hidaka T., Shima T., Nagira K., Ieki M., Nakamura T, Aono Y., Kuraishi Y., Arai T.
  • Journal Title: Eur J Pain 13 Pages: 22-27
• [Journal Article] SV40 T antigen disrupted the cell metabolism and the balance between proliferation and apoptosis in lens tumors of transgenic mice (2009)
  • Author(s): Zheng HC., Nakamura T., Zheng Y., Nakanishi Y., Tabuchi Y., Uchiyama A., Takahashi H., Takano Y.
  • Journal Title: J Cancer Res Clin Oncol. 135 Pages: 1521-1532
  • Peer Reviewed
• [Journal Article] DNAウイルス(SV40T抗原)により誘発したマウス水晶体上皮性腫瘍を用いた新たな癌治療戦略の開発 (2008)
  • Author(s): 中村隆文
  • Journal Title: 日本産科婦人科学会東北連合地方部会誌 55 Pages: 149-156
• [Journal Article] DNAウイルス(SV40T抗原)により誘発したマウス水晶体上皮性腫瘍を用いた新たな癌治療戦略の開発 (2008)
  • Author(s): 中村隆文
  • Journal Title: 日本産科婦人科学会東北連合地方部会誌 第55号 Pages: 149-156
• [Presentation] DNAウイルス(SV40T抗原)により誘発したマウス水晶体上皮腫瘍を用いた新な癌治療戦略の開発 (2009)
  • Author(s): 中村隆文
  • Organizer: 第174回川崎医学会講演会
  • Place of Presentation: 川崎医科大学
  • Year and Date: 2009-12-22
• [Presentation] SV40T抗原誘発担癌マウスを用いた漢方薬による癌治療効果の検討 (2008)
  • Author(s): 中村隆文
  • Organizer: 第60回日本産婦人科学会
  • Year and Date: 2008-04-12
• [Presentation] SV40T抗原誘発担癌マウスを用いた漢方薬による癌治療効果の検討 (2007)
  • Author(s): 中村隆文
  • Organizer: coeシンポジウム
  • Place of Presentation: 富山県民会館
  • Year and Date: 2007-11-16
• [Presentation] SV40T抗原誘発担癌マウスを用いた漢方薬による癌治療効果の検討 (2007)
  • Author(s): 中村 隆文
  • Organizer: 21COEシンポジウム
  • Place of Presentation: 富山県民会館
  • Year and Date: 2007-11-16