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Analysis of the retinal fascin gene for retinitis pigmentosa in zebrafish

Research Project

Project/Area Number 19592018
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionOsaka University

Principal Investigator

SAISHIN Yoshitsugu  Osaka University, 医学部, 准教授 (30379193)

Co-Investigator(Kenkyū-buntansha) TSUJIKAWA Motokazu  大阪大学, 医学系研究科, 助教 (70419472)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords眼科学 / 遺伝子 / 網膜色素変性 / 脳・神経 / 蛋白質 / 応用動物 / 臨床 / 発現制御
Research Abstract

Retinal fascin gene has been analyzed to determine its role in Japanese patients with autosomal dominant retinitis pigmentosa. We found the retinal fascin gene in zebrafish as well as in human. Morphological changes have not been found, however, some functional change might occur in transgenic fish, which could be helpful to determine the cause of retinitis pigmentosa.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (53 results)

All 2010 2009 2008 2007

All Journal Article (49 results) (of which Peer Reviewed: 49 results) Presentation (4 results)

  • [Journal Article] Nocturnal Intermittent Serious Hypoxia and Reoxygenation in Proliferative Diabetic Retinopathy Cases.2010

    • Author(s)
      Shiba T, Maeno T, Saishin Y, Hori Y, Takahashi M
    • Journal Title

      Am J Ophthalmol (Epub ahead of print)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical findings in unilateral acute idiopathic maculopathy : New findings in acute idiopathic maculopathy.2010

    • Author(s)
      Haruta H, Sawa M, Saishin Y, Ohguro N, Tano Y
    • Journal Title

      Int Ophthalmol 30

      Pages: 199-202

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anterior segment optical coherence tomography assessment of iris bombe before and after laser iridotomy in patients with uveitic secondary glaucoma.2010

    • Author(s)
      Miki A, Saishin Y, Kuwamura R, Ohguro N, Tano Y
    • Journal Title

      Acta Ophthalmol 88

      Pages: 26-27

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nocturnal Intermittent Serious Hypoxia and Reoxygenation in Proliferative Diabetic Retinopathy Cases2010

    • Author(s)
      Shiba T, Maeno T, Saishin Y, Hori Y, Takahashi M.
    • Journal Title

      Am J Ophthalmol. (Epub ahead of print)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pupilloplasty for congenital pupillary-iris-lens membrane with 25-gauge vitreous cutter.2009

    • Author(s)
      Kandori M, Saishin Y, Kusaka S, Shimojyo H, Otori Y, Tano Y
    • Journal Title

      Acta Ophthalmol (Epub ahead of print)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of iris melanocytoma transformed to malignant melanoma.2009

    • Author(s)
      Inoue R, Saishin Y, Shima C, Yoshikawa H, Ohguro N, Tano Y
    • Journal Title

      Jpn J Ophthalmol 53

      Pages: 271-273

    • NAID

      10025150194

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression and regression of choroidal neovascularization by the multitargeted kinase inhibitor pazopanib.2009

    • Author(s)
      Takahashi K, Saishin Y, Saishin Y, King AG, Levin R, Campochiaro PA
    • Journal Title

      Arch Ophthalmol 127

      Pages: 494-499

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive gene-expression profile in murine oxygen-induced retinopathy.2009

    • Author(s)
      Sato T, Kusaka S, Hashida N, Saishin Y, Fujikado T, Tano Y
    • Journal Title

      Br J Ophthalmol 93

      Pages: 96-103

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Macular autofluorescence in eyes with cystoid macula edema, detected with 488 nm-excitation but not with 580 nm-excitation.2009

    • Author(s)
      Bessho K, Gomi F, Harino S, Sawa M, Sayanagi K, Tsujikawa M, Tano Y
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol 247

      Pages: 729-734

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intravitreal bevacizumab for choroidal neovascularization attributable to pathological myopia: one-year results.2009

    • Author(s)
      Ikuno Y, Sayanagi K, Soga K, Sawa M, Tsujikawa M, Gomi F, Tano Y
    • Journal Title

      Am J Ophthalmol 147

      Pages: 94-100

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pupilloplasty for congenital pupillary-iris-lens membrane with 25-gauge vitreous cutter2009

    • Author(s)
      Kandori M, Saishin Y, Kusaka S, Shimojyo H, Otori Y, Tano Y.
    • Journal Title

      Acta Ophthalmol. (Epub ahead of print)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of iris melanocytoma transformed to malignant melanoma2009

    • Author(s)
      Inoue R, Saishin Y, Shima C, Yoshikawa H, Ohguro N, Tano Y.
    • Journal Title

      Jpn J Ophthalmol. 53

      Pages: 271-273

    • NAID

      10025150194

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression and regression of choroidal neovascularization by the multitargeted kinase inhibitor pazopanib2009

    • Author(s)
      Takahashi K, Saishin Y, -------, Levin R, Campochiaro PA.
    • Journal Title

      Arch Ophthalmol. 127

      Pages: 494-499

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical findings in unilateral acute idiopathic maculopathy : New findings in acute idiopathic maculopathy.2009

    • Author(s)
      Haruta H, ----Saishin Y, ---Tano Y.
    • Journal Title

      Int Ophthalmol. Epub

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive gene-expression profile in murine oxygen-induced retinopathy.2009

    • Author(s)
      Sato T, ----Saishin Y, -----Tano Y.
    • Journal Title

      Br J Ophthalmol. 93

      Pages: 96-103

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macular autofluorescence in eyes with cystoid macula edema, detected with 488 nm-excitation but not with 580 nm-excitation.2009

    • Author(s)
      Bessho K, ---Tsujikawa M, Tano Y.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol. Epub

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intravitreal bevacizumab for choroidal neovascularization attributable to pathological myopia : one-year results.2009

    • Author(s)
      Ikuno Y, ---Tsujikawa M, ---Tano Y.
    • Journal Title

      Am J Ophthalmol. 147

      Pages: 94-100

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of primary intraocular lymphoma with intravitreal methotrexate.2008

    • Author(s)
      Sou R, Ohguro N, Maeda T, Saishin Y, Tano Y
    • Journal Title

      Jpn J Ophthalmol 52

      Pages: 167-174

    • NAID

      10024153962

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lacquer crack formation and choroidal neovascularization in pathologic myopia.2008

    • Author(s)
      Ikuno Y, Sayanagi K, Soga K, Sawa M, Gomi F, Tsujikawa M, Tano Y
    • Journal Title

      Retina 28

      Pages: 1124-1131

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal fundus autofluorescence patterns in myopic choroidal neovascularisation.2008

    • Author(s)
      Sawa M, Gomi F, Tsujikawa M, Ikuno Y, Sakaguchi H, Sayanagi K, Tano Y
    • Journal Title

      Br J Ophthalmol 92

      Pages: 1236-1240

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Marked vascular changes of polypoidal choroidal vasculopathy after photodynamic therapy.2008

    • Author(s)
      Wakabayashi T, Gomi F, Sawa M, Tsujikawa M, Tano Y
    • Journal Title

      Br J Ophthalmol 92

      Pages: 936-940

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of one intravitreal injection of bevacizumab in diabetic macular oedema.2008

    • Author(s)
      Fang X, Sakaguchi H, Gomi F, Oshima Y, Sawa M, Tsujikawa M, Ikuno Y, Kamei M, Kusaka S, Tano Y
    • Journal Title

      Acta Ophthalmol 86

      Pages: 800-805

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fundus autofluorescence after full macular translocation surgery for myopic choroidal neovascularization.2008

    • Author(s)
      Sawa M, Gomi F, Ohji M, Tsujikawa M, Fujikado T, Tano Y
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol 246

      Pages: 1087-1095

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Morphologic changes in acute central serous chorioretinopathy evaluated by fourier-domain optical coherence tomography.2008

    • Author(s)
      Fujimoto H, Gomi F, Wakabayashi T, Sawa M, Tsujikawa M, Tano Y
    • Journal Title

      Ophthalmology 115

      Pages: 1494-1500

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age at onset curves of retinitis pigmentosa.2008

    • Author(s)
      Tsujikawa M, Wada Y, Sukegawa M, Sawa M, Gomi F, Nishida K, Tano Y
    • Journal Title

      Arch Ophthalmol 126

      Pages: 337-340

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complications in patients after intravitreal injection of bevacizumab.2008

    • Author(s)
      Shima C, Sakaguchi H, Gomi F, Kamei M, Ikuno Y, Oshima Y, Sawa M, Tsujikawa M, Kusaka S, Tano Y
    • Journal Title

      Acta Ophthalmol 86

      Pages: 372-376

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of intravitreal bevacizumab for polypoidal choroidal vasculopathy.2008

    • Author(s)
      Gomi F, Sawa M, Sakaguchi H, Tsujikawa M, Oshima Y, Kamei M, Tano Y
    • Journal Title

      Br J Ophthalmol 92

      Pages: 70-73

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anterior segment optical coherence tomography assessment of iris bombe before and after laser iridotomy in patients with uveitic secondary glaucoma.2008

    • Author(s)
      Miki A, Saishin Y, Kuwamura R, Ohguro N, Tano Y.
    • Journal Title

      Acta Ophthalmol. Epub

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of primary intraocular lymphoma with intravitreal methotrexate.2008

    • Author(s)
      Sou R, -----Saishin Y, Tano Y.
    • Journal Title

      Jpn J Ophthalmol. 52

      Pages: 164-174

    • NAID

      10024153962

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lacquer crack formation and choroidal neovascularization in pathologic myopia.2008

    • Author(s)
      Ikuno Y, -----Tsujikawa M, Tano Y.
    • Journal Title

      Retina. 28

      Pages: 1124-1131

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal fundus autofluorescence patterns in myopic choroidal neovascularisation.2008

    • Author(s)
      Sawa M, ---Tsujikawa M, ---Tano Y.
    • Journal Title

      Br J Ophthalmol. 92

      Pages: 1236-1240

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Marked vascular changes of polypoidal choroidal vasculopathy after photodynamic therapy.2008

    • Author(s)
      Wakabayashi T, --Tsujikawa M, Tano Y.
    • Journal Title

      Br J Ophthalmol. 92

      Pages: 936-940

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of one intravitreal injection of bevacizumab in diabetic macular oedema.2008

    • Author(s)
      Fang X, ---Tsuiikawa M, ---Tano Y.
    • Journal Title

      Acta Ophthalmol. 86

      Pages: 800-805

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fundus autofluorescence after full macular translocation surgery for myopic choroidal neovascularization.2008

    • Author(s)
      Sawa M, ---Tsujikawa M, ---Tano Y.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol. 246

      Pages: 1087-1095

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphologic changes in acute central serous chorioretinopathy evaluated by fourier-domain optical coherence tomography.2008

    • Author(s)
      Fujimoto H, ----Tsujikawa M, Tano Y.
    • Journal Title

      Ophthalmology. 115

      Pages: 1494-1500

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age at onset curves of retinitis pigmentosa.2008

    • Author(s)
      Tsujikawa M, --------Tano Y.
    • Journal Title

      Arch Ophthalmol. 126

      Pages: 337-340

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of intravitreal bevacizumab for polypoidal choroidal vasculopathy.2008

    • Author(s)
      Gomi F, -Tsujikawa M, -Tano Y.
    • Journal Title

      Br J Ophthalmol. 92

      Pages: 70-73

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of positioning the cell nucleus in vertebrate photoreceptors2007

    • Author(s)
      Tsujikawa M, Omori Y, Biyanwila J, Malicki J.
    • Journal Title

      Proc Natl Acad Sci U S A 104

      Pages: 14819-14824

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiographic lesion of polypoidal choroidal vasculopathy on indocyanine green and fluorescein angiography.2007

    • Author(s)
      Gomi F, Sawa M, Mitarai K, Tsujikawa M, Tano Y
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol 245

      Pages: 1421-1427

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intravitreal bevacizumab for idiopathic choroidal neovascularization after previous injection with posterior subtenon triamcinolone.2007

    • Author(s)
      Gomi F, Nishida K, Oshima Y, Sakaguchi H, Sawa M, Tsujikawa M, Tano Y
    • Journal Title

      Am J Ophthalmol 143

      Pages: 507-510

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Allelic homogeneity in Avellino corneal dystrophy due to a founder effect.2007

    • Author(s)
      Tsujikawa K, Tsujikawa M, Watanabe H, Maeda N, Inoue Y, Fujikado T, Tano Y
    • Journal Title

      J Hum Genet 52

      Pages: 92-97

    • NAID

      10018515296

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intravitreal injection of bevacizumab for choroidal neovascularisation associated with pathological myopia.2007

    • Author(s)
      Sakaguchi H, Ikuno Y, Gomi F, Kamei M, Sawa M, Tsujikawa M, Oshima Y, Kusaka S, Tano Y
    • Journal Title

      Br J Ophthalmol 91

      Pages: 161-165

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 後極部に病巣が初発した壊死性ヘルペス性網膜症の1例2007

    • Author(s)
      西信良嗣, 大黒伸行, 田野保雄
    • Journal Title

      日本眼科紀要 58

      Pages: 433-436

    • NAID

      10024293998

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of positioning the cell nucleus in vertebrate photoreceptors.2007

    • Author(s)
      Tsujikawa M, -Malicki J.
    • Journal Title

      Proc Natl Acad Sci U S A. 104

      Pages: 14819-14824

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complications in patients after intravitreal injection of bevacizumab.2007

    • Author(s)
      Shims C, -Tsuiikawa M, -Tano Y.
    • Journal Title

      Acta Ophthalmol Scand. Epub

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiographic lesion of polypoidal choroidal vasculopathy on indocyanine green and fluorescein angiography.2007

    • Author(s)
      Gomi F, -Tsujikawa M, Tano Y.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol. 245

      Pages: 1421-1427

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intravitreal bevacizumab for idiopathic choroidal neovascularization after previous injection with posterior subtenon triamcinolone.2007

    • Author(s)
      Gomi F, -Tsujikawa M, Tano Y.
    • Journal Title

      Am J Ophthalmol. 143

      Pages: 507-510

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allelic homogeneity in Avellino corneal dystrophy due to a founder effect.2007

    • Author(s)
      Tsujikawa K, Tsujikawa M, -Tano Y.
    • Journal Title

      J Hum Genet. 52

      Pages: 92-97

    • NAID

      10018515296

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intravitreal injection of bevacizumab for choroidal neovascularisation associated with pathological myopia.2007

    • Author(s)
      Sakaguchi H, -Tsujikawa M, -Tano Y.
    • Journal Title

      Br J Ophthalmol. 91

      Pages: 161-165

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Malignant transformation of an iris melanocytoma to melanoma.2008

    • Author(s)
      Saishin Y, Inoue R, Shima C, Yoshikawa H, Ohguro N, Tano Y
    • Organizer
      World Ophthalmology Congress
    • Place of Presentation
      Hong Kong China
    • Year and Date
      2008-07-01
    • Related Report
      2009 Final Research Report
  • [Presentation] Oral administration of the VEGF receptor kinase inhibitor Pazopanib causes suppression and regression of choroidal neovascularization in mice.2008

    • Author(s)
      Saishin Y, Takahashi K, Saishin Y, King A, Levin R, Campochiaro PA
    • Organizer
      Annual Meeting of Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, Florida USA
    • Year and Date
      2008-04-29
    • Related Report
      2009 Final Research Report
  • [Presentation] Clinical evaluation of uveitis with Behcet disease after fifteen years follow-up.2007

    • Author(s)
      Saishin Y, Ohguro N, Tano Y
    • Organizer
      9th International Congress of International Ocular Inflammation Society
    • Place of Presentation
      Paris, France
    • Year and Date
      2007-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] Systemic administration of IL-6 receptor antibody suppresses choroidal neovascularization (CNV) in mice2007

    • Author(s)
      Hoki S, Saishin Y, Mashimo H, Haruta H, Tsujikawa M, Ohguro N, Tano Y
    • Organizer
      Annual Meeting of Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Fort Lauderdale, Florida USA
    • Year and Date
      2007-05-07
    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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