Analysis of the retinal fascin gene for retinitis pigmentosa in zebrafish
Project/Area Number |
19592018
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Ophthalmology
|
Research Institution | Osaka University |
Principal Investigator |
SAISHIN Yoshitsugu Osaka University, 医学部, 准教授 (30379193)
|
Co-Investigator(Kenkyū-buntansha) |
TSUJIKAWA Motokazu 大阪大学, 医学系研究科, 助教 (70419472)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 眼科学 / 遺伝子 / 網膜色素変性 / 脳・神経 / 蛋白質 / 応用動物 / 臨床 / 発現制御 |
Research Abstract |
Retinal fascin gene has been analyzed to determine its role in Japanese patients with autosomal dominant retinitis pigmentosa. We found the retinal fascin gene in zebrafish as well as in human. Morphological changes have not been found, however, some functional change might occur in transgenic fish, which could be helpful to determine the cause of retinitis pigmentosa.
|
Report
(4 results)
Research Products
(53 results)