| Project/Area Number |
19592160
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
SAIGUSA Tasashi Nihon University, 歯学部, 専任講師 (50277456)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Satoshi 日本大学, 歯学部, 助教 (00386096)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | カテコラミン / 大脳基底核 / 口腔ジスキネジア / 麻薬性鎮痛薬 / 鎮痛補助薬 / ドパミン / 線条体 / 脳微小透析法 / SKF38393 / dexamphetamine / reserpine / α-methyl-p-tyrosine / ラット / ノルアドレナリン / β受容体 / NA取り込み阻害薬 / reboxetine / 側坐核 / endomorphin-1 / endomorphin-2 / GABA / GABA_B受容体 |
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| Research Abstract |
Oral dyskinesia is a neurological syndrome associated with aging or use of drugs for Parkinson's disease and antipsychotics. It is characterized by repetitive stereotyped oral movement The detaned biological basis of the disorder remains unclear, but the phamaco-behavioural studies suggest that enhance of dopamine function in the nucleus accumbens and striatum plays a pivotal role for the induction of repetitive jaw movements of rats. Therefore, in the present study, we nvestigated the mechanisms of increase in accumbal and striatal dopaminergic activity in freely moving rats, using the in vivo brain microdialysis technique.
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