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Basic research of a novel dental material : Calcium Titanium Oxide-Amorphous Carbon for applying the lining material

Research Project

Project/Area Number 19592236
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionOkayama University

Principal Investigator

TAKAGI Yoru  Okayama University, 大学院・医歯薬学総合研究科, 非常勤講師 (20124696)

Co-Investigator(Kenkyū-buntansha) NAGAI Noriyuki  岡山大学, 名誉教授 (90085770)
NAGATSUKA Hitoshi  岡山大学, 大学院・医歯薬学総合研究科, 教授 (70237535)
SUZUKI Kazuomi  岡山大学, 大学院・医歯薬学総合研究科, 教授 (30050058)
YAMAMOTO Toshio  岡山大学, 大学院・医歯薬学総合研究科, 教授 (30107776)
IRIE Masao  岡山大学, 大学院・医歯薬学総合研究科, 助教 (90105594)
TSUJIGIWA Hidetsugu  岡山大学, 大学院・医歯薬学総合研究科, 助教 (70335628)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords歯科材料 / 生体材料 / チタン酸カルシウム / ナノ粒子 / 裏装材 / 細胞反応 / アルコキシド法 / ライナー材 / チタン / チタン酸 / 細胞毒性 / 非晶質炭素
Research Abstract

We have developed modified thermal decomposition method to obtained "calcium titanium oxide-amorphous carbon" (CaTiO3-aC). The purpose of the research was to evaluate the effect of this material as nanoparticles for applying the dental material. We analyzed the chemical composition of the particles and studied it's influence on the cell. Our results suggest that CaTiO3-aC plays a dominant effect on cell response, which could be considered as an important biomaterial for not only dental materials but also medical and industrial materisls.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (56 results)

All 2010 2009 2008 2007

All Journal Article (25 results) (of which Peer Reviewed: 25 results) Presentation (31 results)

  • [Journal Article] Effect of Fluoride-substituted Apatite on In Vivo Bone Formation.2010

    • Author(s)
      Inoue M, Rodriguez AP, Nagai N, Nagatsuka H, Legeros RZ, Tsujigiwa H, Inoue M, Kishimoto E, Takagi S
    • Journal Title

      J Biomater Appl (Epub ahead of print)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of a new titanium coating material(CaTiO3-aC)prepared by thermal decomposition method on osteoblastic cell response.2010

    • Author(s)
      Inoue M
    • Journal Title

      J Biomater Appl. 24

      Pages: 657-672

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of the microenvironment on gene and protein expression of odontogenicand osteogenic-like cells.2009

    • Author(s)
      Rodriguez AP, Tsujigiwa H, Gunduz M, Cengiz B, Nagai N, Tamamura R, Borkosky SS, Takagi T, Inoue M, Nagatsuka H
    • Journal Title

      Biocell 33

      Pages: 39-47

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of the microenvironment on gene and protein expression of odontogenic-like and osteogenic-like cells.2009

    • Author(s)
      Rodriguez AP
    • Journal Title

      Biocell. 33

      Pages: 39-47

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of New Titanium CoatinMaterial (CaTiO3-aC) with Modified TDecomposition Method2008

    • Author(s)
      Nagai N, Okauchi M, Rodriguez A, Gunduz M, Hu H, Kubota M, Nagaoka N, Inoue M, Nagatsuka H, Takagi T, Akao M
    • Journal Title

      Journal of Hard Tissue Biology 17

      Pages: 47-54

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemical Analysis of a NoveCoating Material, CaTiO3-aC.2008

    • Author(s)
      Okauchi-Yabuuchi M, Tamamura R, Nagaoka N, Takagi S, Kishimoto E, Takagi T, Rodriguez A, Inoue M, Nagatsuka H, Akao M, Nagai N
    • Journal Title

      Journal of Hard Tissue Biology 17

      Pages: 115-120

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of New Titanium Coating Material (CaTiO_3-aC)with Modified Thermal Decomposition Method2008

    • Author(s)
      Nagai N
    • Journal Title

      Journal of Hard Tissue Biology 17(2)

      Pages: 47-54

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical Analysis of a Novel Coating Material, CaTiO_3-aC.2008

    • Author(s)
      Okauchi-Yabuuchi M
    • Journal Title

      Journal of Hard Tissue Biology 17(3)

      Pages: 115-120

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression of jagged2 in mandibular condylar cartilage development.2008

    • Author(s)
      Shimizu T
    • Journal Title

      Eur J Med Res 13(1)

      Pages: 1-3

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of ING3 mRNA expression predicts poor prognosis in head and neck cancer.2008

    • Author(s)
      Gunduz M
    • Journal Title

      Cancer Sci 99(3)

      Pages: 531-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma.2008

    • Author(s)
      Rivera RS
    • Journal Title

      Virchows Arch 452(1)

      Pages: 27-32

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Notch signaling in mandibular condylar cartilage development.2007

    • Author(s)
      Shimizu T
    • Journal Title

      Eur J Med Res 12(10)

      Pages: 515-9

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunolocalization of cell signaling molecules in the granular cell ameloblastoma.2007

    • Author(s)
      Sathi GS
    • Journal Title

      J Oral Pathol Med 36(10)

      Pages: 609-14

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of the neoplastic nature and biological potential of sporadic and nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumor.2007

    • Author(s)
      Katase N
    • Journal Title

      J Oral Pathol Med 36(9)

      Pages: 550-4

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive loss of heterozygosity analysis and identification of a novel hotspot at 3p21 in salivary gland neoplasms.2007

    • Author(s)
      Honjo N
    • Journal Title

      Otolaryngol Head Neck Surg 137(1)

      Pages: 119-25

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Depletion of O6-methylguanine-DNA methyltransferase by O6-benzylguanine enhances 5-FU cytotoxicity in colon and oral cancer cell lines.2007

    • Author(s)
      Murakami J
    • Journal Title

      Oncol Rep 17(6)

      Pages: 1461-7

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Translocation of heparanase into nucleus results in cell differentiation.2007

    • Author(s)
      Nobuhisa T
    • Journal Title

      Cancer Sci 98(4)

      Pages: 535-40

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An immunohistochemical evaluation of BMP-2, -4, osteopontin, osteocalcin and PCNA between ossifying fibromas of the jaws and peripheral cemento-ossifying fibromas on the gingiva.2007

    • Author(s)
      Ono A
    • Journal Title

      Oral Oncol 43(4)

      Pages: 339-44

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Heparanase in the Release of Heparan Sulphate Binding Growth Factors in Odontogenic Tumors.2007

    • Author(s)
      Phuu Pwint Han
    • Journal Title

      J Hard Tissue Biology 16(1)

      Pages: 23-30

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization and Gene Expression Profiling of Human Mesenchymal Stem Cells.2007

    • Author(s)
      Hiroki Mori
    • Journal Title

      J Hard Tissue Biology 16(1)

      Pages: 36-41

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Origin of Osteoblasts Involved in the Mechanisn of Ectopic Bone Formation Induced by KUSA/A1 Cells with Honeycomb Carrier.2007

    • Author(s)
      Rodriguez Andrea P
    • Journal Title

      J Hard Tissue Biology 16(2)

      Pages: 75-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wnt5a Overexpression in Thick Primary Oral Mucosal Melanomas: Implications for its Role in Tumor Progression.2007

    • Author(s)
      Jing Xiao
    • Journal Title

      J Hard Tissue Biology 16(2)

      Pages: 79-86

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Study of Palatal Cell Proliferation and Apoptosis in Retinoic Acid Induced Mouse Cleft Palate Varied with Different Developmental Stage.2007

    • Author(s)
      Jing Xiao
    • Journal Title

      J Hard Tissue Biology 16(3)

      Pages: 125-30

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A pigmented calcifying cystic odontogenic tumor associated with compound odontoma: a case report and review of literature.2007

    • Author(s)
      Han PP
    • Journal Title

      Head Face Med 3:35(online)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological Analysis of a Candidate Stem Cell -KUSA/A1 cell- for Bone Tissue Engineering.2007

    • Author(s)
      Andrea P. Rodriguez
    • Journal Title

      J Hard Tissue Biology 16(1)

      Pages: 1-14

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新規生体材料チタン酸カルシウム-炭酸カルシウム(CaTiO3-CaCO3)の細胞学的検討2009

    • Author(s)
      井上美穂
    • Organizer
      第51回歯科基礎医学会学術大会・総会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 新規コーティング材CaTiO3-aCの組織学的検討2009

    • Author(s)
      玉村亮
    • Organizer
      第18回硬組織再生生物学会総会・学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-05
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Effect of CaTiO3-C coating by thermal decomposition method on osteoblastic cell response2008

    • Author(s)
      M. Inoue
    • Organizer
      The 4th International Symposium on Apatite and Correlative Biomaterials
    • Place of Presentation
      フィリピン
    • Year and Date
      2008-09-12
    • Related Report
      2009 Final Research Report
  • [Presentation] Effect of CaTiO_3-C coating by thermal decomposition method on osteoblastic cell response2008

    • Author(s)
      Inoue M
    • Organizer
      The 4^<th> International Symposium on Apatite and Correlative Biomaterials
    • Place of Presentation
      フィリピン
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規生体材料(チタン酸カルシウム-非晶質炭素複合物CaTiO3-aC)の細胞学的検討2008

    • Author(s)
      松田寛之
    • Organizer
      第17回硬組織再生生物学会学術大会・総会
    • Place of Presentation
      徳島
    • Year and Date
      2008-08-30
    • Related Report
      2009 Final Research Report
  • [Presentation] 新規生体材料(チタン酸カルシウム-非晶質炭素複合物CaTiO_3-aC)の細胞学的検討2008

    • Author(s)
      松田寛之
    • Organizer
      第17回硬組織再生生物学会学術大会・総会
    • Place of Presentation
      徳島
    • Year and Date
      2008-08-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Clinicopathological Evaluation of Oral Mucosal Melanoma.2007

    • Author(s)
      Rivera RS
    • Organizer
      2nd International Working Group Meeting on Tropical Oral Health
    • Place of Presentation
      Okayama
    • Year and Date
      2007-11-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] シェーグレン症候群の進行と口唇腺中のヒトβデフェンシンの発現様式との関係2007

    • Author(s)
      金田祥弘
    • Organizer
      第52回日本口腔外科学会総会・学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-09-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] A basic research of CaTiO3-C as a coating material for implants2007

    • Author(s)
      胡海龍
    • Organizer
      第16回硬組織再生生物学会
    • Place of Presentation
      長野
    • Year and Date
      2007-09-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新規生体材料(チタン酸カルシウム-非晶質炭素複合物CaTiO3-C)の細胞学的検討2007

    • Author(s)
      井上美穂
    • Organizer
      第16回硬組織再生生物学会
    • Place of Presentation
      長野
    • Year and Date
      2007-09-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] 間接リウマチ滑膜細胞におけるクラスター分化抗原CD81の役割2007

    • Author(s)
      森宏樹
    • Organizer
      第16回硬組織再生生物学会
    • Place of Presentation
      長野
    • Year and Date
      2007-09-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Biological analysis of a candidate stem cell -KUSA/A1 cell- for bone tissue engineering.2007

    • Author(s)
      Rodriguez Andrea Paola
    • Organizer
      第16回硬組織再生生物学会
    • Place of Presentation
      長野
    • Year and Date
      2007-09-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] 骨髄由来間葉系幹細胞の歯牙構成細胞への分化能についての検討2007

    • Author(s)
      辻極秀次
    • Organizer
      第16回硬組織再生生物学会
    • Place of Presentation
      長野
    • Year and Date
      2007-09-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] 歯原性腫瘍の悪性変化とNotchシグナリング2007

    • Author(s)
      中野敬介
    • Organizer
      第16回硬組織再生生物学会
    • Place of Presentation
      長野
    • Year and Date
      2007-09-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] 下顎頭軟骨の発生におけるNotchシグナルの出現2007

    • Author(s)
      清水貴子
    • Organizer
      第16回硬組織再生生物学会
    • Place of Presentation
      長野
    • Year and Date
      2007-09-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Ameloblastomaの悪性変化におけるNotchシグナルの関与2007

    • Author(s)
      中野敬介
    • Organizer
      第49回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      北海道
    • Year and Date
      2007-08-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] 頭頸部癌におけるEGFRシグナル経路の分子生物学及び組織病理的解析2007

    • Author(s)
      グンデゥズ メーメット
    • Organizer
      第49回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      北海道
    • Year and Date
      2007-08-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] 頭頸部癌における癌抑制遺伝子ファミリー新規メンバーING3及びING4の分子生物学的解析2007

    • Author(s)
      グンデゥズ エスラ
    • Organizer
      第49回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      北海道
    • Year and Date
      2007-08-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] インプラントコーティング材としてのチタン酸カルシウム-非晶質炭素複合物(CaTiO3-C)の基礎的研究2007

    • Author(s)
      岡内美佳
    • Organizer
      第49回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      北海道
    • Year and Date
      2007-08-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] NOTCH SIGNALINGによる下顎軟骨発生の調節2007

    • Author(s)
      清水貴子
    • Organizer
      第49回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      北海道
    • Year and Date
      2007-08-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 顆粒細胞型エナメル上皮腫におけるシグナル分子の免疫組織化学的検討2007

    • Author(s)
      玉村亮
    • Organizer
      第18回日本口腔病理学会総会・学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2007-08-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 下顎歯肉腫瘍2007

    • Author(s)
      片瀬直樹
    • Organizer
      第18回日本口腔病理学会総会・学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2007-08-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 頭頸部癌における転移抑制遺伝子候補のmRNA発現の解析2007

    • Author(s)
      福島邦博
    • Organizer
      第31回日本頭頸部癌学会・第28回頭頸部手術手技研究会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 耳下腺腫瘍におけるヘテロ接合性の消失の検討2007

    • Author(s)
      小野田友男
    • Organizer
      第31回日本頭頸部癌学会・第28回頭頸部手術手技研究会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Down-regulation of ING3 mRNA Expression Predicts Poor Prognosis in Head and Neck cancer.2007

    • Author(s)
      Beder Levent
    • Organizer
      第31回日本頭頸部癌学会・第28回頭頸部手術手技研究会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Molecular analysis of EGFR-Ras-Raf pathway in head and neck cancer.2007

    • Author(s)
      Gunduz Mehmet
    • Organizer
      第31回日本頭頸部癌学会・第28回頭頸部手術手技研究会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Molecular and Histopathological Analysis of the EGFR-Ras-Raf Pathway in Head and Neck Squamous Cell Carcinomas.2007

    • Author(s)
      Gunduz M
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Molecular Analysis of ING3 and ING4 and Their Prognostic Role in Head and Neck Cancers.2007

    • Author(s)
      Gunduz E
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] mRNA expression analysis of ADAM-TS-aggrecanases in head and neck cancers.2007

    • Author(s)
      Demircan K
    • Organizer
      98th annual meeting of AACR
    • Place of Presentation
      Los Angeles
    • Related Report
      2007 Annual Research Report
  • [Presentation] Molecular analysis of ING4 and its splicing variants in oral cancer.2007

    • Author(s)
      Gunduz E
    • Organizer
      98th annual meeting of AACR
    • Place of Presentation
      Los Angeles
    • Related Report
      2007 Annual Research Report
  • [Presentation] The Role of EGFR Pathway in Head and Neck Squamous Cell Carcinomas.2007

    • Author(s)
      Gunduz M
    • Organizer
      98th annual meeting of AACR
    • Place of Presentation
      Los Angeles
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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