Development of new therapy of oral infection and cancer by applying innate immunity network.
| Project/Area Number |
19592309
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
OKUMURA Kazuhiko Health Sciences University of Hokkaido, 歯学部, 講師 (60194510)
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| Co-Investigator(Kenkyū-buntansha) |
ISOGAI Emiko 北海道医療大学, 歯学部, 講師 (80113570)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 自然免疫分子 / カセリシジン・ファミリー / hCAP18 / LL-37 / 口腔感染症 / 口腔扁平上皮癌 / アポトーシス / ネクローシス / 樹状細胞 / 口腔扁平上皮癌細胞 / 抗菌ペプチド / 抗腫瘍活性 / 抗菌効果 / 細胞浸潤能 / 細胞遊走能 / 基質分解酵素 / 癌抑制遺伝子 / 自然免疫 / 獲得免疫 / カテリシジンファミリー / 抗腫瘍効果 |
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| Research Abstract |
We studied the antimicrobial and antitumor effects of various host defense peptides (HDPs) associates with innate immunity. Additionally, we demonstrated the only member of the cathelicidin family identified in humans, as human cationic antimicrobial protein 18 (hCAP18) regulates signal transduction in epithelial cells and squamous cell carcinoma cells. Our results demonstrated that the bacterial killing of hCAP18 was synergistic with defensin and lactobacilluspeptide, as lactacin. In addition, we show that hCAP18 encoded CAMP gene is tumor suppressive activity in human squamous cell carcinoma.
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Report
(4 results)
Research Products
(22 results)
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[Presentation] Tumor suppression by hCAP18 in oral squamous cell carcinoma cells.2009
Author(s)
Okumura, K., Sawada, N., Taira, H., Isogai, E., Shibata, T., Isogai, H.
Organizer
IADR-Continental European Division (CED)
Place of Presentation
Gasteig Convention Centre, Munich, Germany
Related Report
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[Presentation] Tumor suppression by hCAP18 in oral squamous cell carcinoma cells.2009
Author(s)
Okumura, K., Sawada, N., Taira, H., Isogai, E., Shibata, T., Isogai, H.
Organizer
IADR-Continental European Division (CED),
Place of Presentation
Gasteig Convention Centre, Munich, Germany.
Related Report
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[Presentation] Antimicrobial activity of tick defensins against Lyme disease spirochetes and bacteria isolated from the midgut.2008
Author(s)
Isogai, H, Isogai, E, Takahashi, K, Kobayashi-Sakamoto, M, Okumura, K
Organizer
11th International conference Lyme borreliosis & other tick-borne diseases
Place of Presentation
Irvine, California, USA
Related Report
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[Presentation] Antimicrobial activity of tick defensins against Lyme disease spirochetes and bacteria isolated from the midgut.2008
Author(s)
Isogai, H., Isogai, E., Takahashi, K., Kobayashi-Sakamoto, M., Okumura, K
Organizer
11^<th> International conference Lyme borrelios is & other tick-borne diseases
Place of Presentation
Irvine, California, USA
Related Report
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[Presentation] Expression of hCAP18 is resistant factor against hCAP18-induces apoptosis2007
Author(s)
Okumura, K. Sawada, N, Muraoka, K. Kato, H, Isogai, E, Hosokawa, Y, Shibata, T, Isogai, H.
Organizer
42nd Annual Meeting IADR/CED-ID
Place of Presentation
Thessaloniki, Greece
Related Report
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