Analysis of the metastasis mechanism and inhibition of the high metastatic potential nude mouse transplantable model of a human adenoid cystic carcinoma

• Project/Area Number: 19592343
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hyogo College of Medicine
• Principal Investigator: HASHITANI Susumu Hyogo College of Medicine, 医学部, 助教 (00330449)
• Co-Investigator(Kenkyū-buntansha): URADE Masahiro 兵庫医科大学, 医学部, 教授 (70104883)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 腺様嚢胞癌 / 転移 / ヌードマウス

Research Abstract

CXCR4高発現患者は肺転移がみられ予後が悪かった.病理組織学的に充実型と転移がみられた篩状型はCXCR4の発現が高かったが、管状型と転移がなかった篩状型は低かった.継代により組織型が篩状型から充実型に変化するヌードマウス可移植性腺様嚢胞癌株ではCXCR4発現の上昇が見られた.また、自然転移ヌードマウス可移植性腺様嚢胞癌株において親株より転移株でCXCR4が高発現であった.これらのことから、腺様嚢胞癌の転移や予後および組織型とCXCR4には強い関連があることが示唆された。

Research Products

• [Journal Article] Relations among expression of CXCR4, histological patterns, and metastatic potential in adenoid cystic carcinoma of the head and neck (2008)
  • Author(s): ZUSHI Y, NOGUCHI K, HASHITANI S, SAKURAI K, SEGAWA E, TAKAOKA K, TOYOHARA Y, TANAKA N, KISHIMOTO H and URADE M,
  • Journal Title: International Journal of Oncology 33 Pages: 1133-1139
  • Peer Reviewed
• [Journal Article] Relations among expression of CXCR4, histological patterns, and metastatic potential in adenoid cystic carcinoma of the head and neck (2008)
  • Author(s): Zushi Y, Noguchi K, Hashitani S, etc.
  • Journal Title: International Journal of Oncology 33 Pages: 1133-1139
  • Peer Reviewed
• [Presentation] Relationship between expression of CXCR4 and histological type in adenoid cystic carcinoma of the head and neck (2007)
  • Author(s): Zushi Y, Noguchi K, Hashitani S, Sakurai K, Takaoka K, Tanaka N, Kishimoto H, Urade M
  • Organizer: 14th the European Cancer Conference (ECCO)
  • Place of Presentation: Barcelona, Spain
• [Presentation] Relationship between expression of CXCR4 and histological type in adenoid cysticcarcinoma of the head and neck (2007)
  • Author(s): Zushi Y, Noguchi K, Hashitani S, Sakurai K, Takaoka K, Tanaka N, Kishimoto H, Urade M
  • Organizer: 14th the European Cancer Conference(ECCO)
  • Place of Presentation: Barcelona,Spain