| Project/Area Number |
19592366
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
|
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| Research Institution | Showa University |
|---|
Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Itsuro 東海大学, 医学部, 教授 (00192500)
MAKI Koutaro 昭和大学, 歯学部, 教授 (80219295)
MIYAMOTO Asami 昭和大学, 歯学部, 助教 (20384349)
WATANABE Miyuki 昭和大学, 歯学部, 助教 (30407572)
綿引 淳一 昭和大学, 歯学部, 研究生 (60384351)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
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| Keywords | 下顎前突症 / ゲノム / 遺伝子 / 頭蓋顎顔面形態 |
|---|
| Research Abstract |
We studied the relationship between six polymorphism genotypes and craniofacial linear measurements obtained from lateral cephalograms of 326 East Asian subjects. There was a significant association between P561T and C422F polymorphisms and mandibular ramus height. These polymorphisms were found almost exclusively in the Asian population, with extremely small frequencies in other populations. GHR polymorphisms are associated with mandibular ramus height in the East Asian population, but this association is likely to be different in other ethnic groups, and may partly explain the differing craniofacial morphology seen among different ethnicities.
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