Exploratory studies on mandibular prognathism susceptibility genes and functional analysis based on genome wide analysis
| Project/Area Number |
19592366
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Itsuro 東海大学, 医学部, 教授 (00192500)
MAKI Koutaro 昭和大学, 歯学部, 教授 (80219295)
MIYAMOTO Asami 昭和大学, 歯学部, 助教 (20384349)
WATANABE Miyuki 昭和大学, 歯学部, 助教 (30407572)
綿引 淳一 昭和大学, 歯学部, 研究生 (60384351)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 下顎前突症 / ゲノム / 遺伝子 / 頭蓋顎顔面形態 |
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| Research Abstract |
We studied the relationship between six polymorphism genotypes and craniofacial linear measurements obtained from lateral cephalograms of 326 East Asian subjects. There was a significant association between P561T and C422F polymorphisms and mandibular ramus height. These polymorphisms were found almost exclusively in the Asian population, with extremely small frequencies in other populations. GHR polymorphisms are associated with mandibular ramus height in the East Asian population, but this association is likely to be different in other ethnic groups, and may partly explain the differing craniofacial morphology seen among different ethnicities.
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Report
(4 results)
Research Products
(75 results)
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[Journal Article] A common variation in EDAR is a genetic determinant of shovel-shaped incisors.2009
Author(s)
Kimura R, Yamaguchi T, Takeda M, Kondo O, Toma T, Haneji K, Hanihara T, Matsukusa H, Kawamura S, Maki K, Osawa M, Ishida H, Oota H.
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Journal Title
Am J Hum Genet 85
Pages: 528-535
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[Presentation] シャベル型切歯の遺伝要因2009
Author(s)
木村亮介, 山口徹太郎, 槇宏太郎, 武田摩耶子, 近藤修, 埴原恒彦, 大澤資樹, 石田肇, 川村正二, 太田博樹
Organizer
第14回日本顔学会大会
Place of Presentation
鹿児島市
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[Presentation] A nonsynonymous SNP in EDAR is associated with tooth shoveling.2009
Author(s)
Kimura R, Yamaguchi T, Maki K, Takeda M, Kondo O, Hanihara T, Osawa M, Ishida H, Kawamura S, Oota H.
Organizer
アメリカ人類遺伝学会
Place of Presentation
Honolulu, Hawaii, USA.
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[Presentation] 顔面骨骨折後の顎変形の咬合再建について.2008
Author(s)
倉林仁美, 代田達夫, 山口徹太郎, 高橋満里子, 上原峰子, 山口雅章, 土佐泰祥, 門松香一, 佐藤兼重, 保阪善昭, 槇宏太郎
Organizer
第18回日本顎変形症学会
Place of Presentation
名古屋
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