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A study on the effect of periodontal diseases on the onset and progression of steatohepatitis.

Research Project

Project/Area Number 19592399
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionHyogo College of Medicine

Principal Investigator

NAKASHO Keiji  Hyogo College of Medicine, 医学部, 准教授 (00217712)

Co-Investigator(Kenkyū-buntansha) OHYAMA Hideki  兵庫医科大学, 医学部, 講師 (90280685)
TERADA Nobuyuki  兵庫医科大学, 医学部, 教授 (50150339)
YAMADA Naoko  兵庫医科大学, 医学部, 講師 (10319858)
YAMANEGI Koji  兵庫医科大学, 医学部, 助教 (00434944)
NAKAMURA Hideji  兵庫医科大学, 医学部, 非常勤講師 (20237423)
URADE Masahiro  兵庫医科大学, 医学部, 教授 (70104883)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords歯周免疫機能学 / 脂肪性肝炎 / 歯周炎 / 肝機能マーカー / 血清IgG抗体価
Research Abstract

In the study to assess clinical parameters of periodontal diseases in patients with non-alcoholic steatohepatitis (NASH) and fatty liver diseases (FLD), we found that the patients with NASH showed the tendency to be more severe in periodontal condition as compared with the patients with FLD. The serum IgG titers against periodontopathic bacteria were also higher in the patients with NASH than the patients with FLD. These results might exhibit the possible effects of periodontal diseases on the pathogenesis of steatohepatitis.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (31 results)

All 2010 2009 2008 2007

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (9 results) Book (2 results)

  • [Journal Article] Acoustic radiation force impulseによる非侵襲的肝線維化診断法の有用性2010

    • Author(s)
      飯島尋子
    • Journal Title

      肝臓 51

      Pages: 54-55

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肝細胞癌を合併した非アルコール性脂肪肝炎(NASH)の臨床病理学的検討2009

    • Author(s)
      菊池勝一, 近藤寿郎, 生田真一, 飯田洋也, 相原司, 安井智明, 柳秀憲, 光信正夫, 覚野綾子, 中正恵二, 山中若樹
    • Journal Title

      肝臓 50

      Pages: 626-633

    • NAID

      10026100711

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The involvement of IL-23 and the Th17 pathway in periodontitis2009

    • Author(s)
      Ohyama H, Kato-Kogoe N, Kuhara A, Nishimura F, Nakasho K, Yamanegi K, Yamada N, Hata M, Yamane J, Terada N
    • Journal Title

      J Dent Res 88

      Pages: 633-638

    • NAID

      130004570957

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] An unusual autopsy case of pyogenic liver abscess caused by periodontal bacteria2009

    • Author(s)
      Ohyama H, Nakasho K, Yamanegi K, Noiri Y, Kuhara A, Kato-Kogoe N, Yamada N, Hata M, Nishimura F, Ebisu S, Terada N
    • Journal Title

      Jpn J Infect Dis 62

      Pages: 381-383

    • NAID

      40016750210

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] An unusual autopsy case of pyogenic liver abscess caused by periodontal bacteria.2009

    • Author(s)
      Hideki Ohyama
    • Journal Title

      Japanese Journal of Infectious Diseases 62

      Pages: 381-383

    • NAID

      40016750210

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肝細胞癌を合併した非アルコール性脂肪肝炎(NASH)の臨床病理学的検討2009

    • Author(s)
      菊池勝一
    • Journal Title

      肝臓 50

      Pages: 626-633

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The involvement of IL-23 and Th17 pathway in periodontitis.2009

    • Author(s)
      Hideki Ohyama
    • Journal Title

      Journal of Dental Research (in press)

    • NAID

      130004570957

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胆嚢hepatoid adenocarcinomaの1例2009

    • Author(s)
      中正恵二
    • Journal Title

      診断病理 25

      Pages: 210-217

    • NAID

      10021930362

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胆嚢hepatoid adenocarcinomaの1例2008

    • Author(s)
      中正恵二, 山根木康嗣, 大山秀樹, 平野博嗣, 山田直子, 秦正樹, 寺田信行, 岡田敏弘, 斉藤慎一, 藤元治朗
    • Journal Title

      診断病理 25

      Pages: 210-217

    • NAID

      10021930362

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 胆嚢Mucin-producing papillary adenocarcinomaの1例2008

    • Author(s)
      中正恵二, 覚野綾子, 大山秀樹, 山根木康嗣, 山田直子, 秦正樹, 平野博嗣, 寺田信行, 相原司, 安井智明, 山中若樹
    • Journal Title

      診断病理 25

      Pages: 104-111

    • NAID

      10021252127

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphisms in the 5' flanking region of IL12RB2 are associated with susceptibility to periodontal diseases in the Japanese population2008

    • Author(s)
      Takeuchi-Hatanaka, K., Ohyama, H., Nishimura, F., Kato-Kogoe, N., Soga, Y., Matsushita, S., Nakasho, K., Yamanegi, K., Yamada, N., Terada, N., Takashiba, S
    • Journal Title

      J. Clin. Periodontol 35

      Pages: 317-323

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transdifferentiation into biliary ductular cells of hepatocytes transplanted into the spleen2008

    • Author(s)
      Watanabe, H., Hata, M., Terada, N., Ueda, H., Yamada, N., Yamanegi, K., Ohyama, H., Kakihana, M., Okamura, H., Nakasho, K
    • Journal Title

      Pathology 40

      Pages: 272-276

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential effect of polymorphisms in the 5'flanking region of IL12RB2 on NK-and T-cell activity2008

    • Author(s)
      Ohyama, H., Kato-Kogoe, N., Nishimura, F., Takeuchi-Hatanaka, K., Matsushita, S., Yamanegi, K., Yamada, N., Hata, M., Nakasho, K., Terada, N
    • Journal Title

      J. Interferon Cytokine Res 28

      Pages: 563-569

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transdifferentiation into biliary ductular cells of hepatocytes transplanted into the spleen.2008

    • Author(s)
      Hirofumi Watanabe
    • Journal Title

      Pathology 40

      Pages: 272-276

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胆嚢Mucin-producing papillary adenocarcinomaの1例2008

    • Author(s)
      中正恵二
    • Journal Title

      診断病理 25

      Pages: 104-111

    • NAID

      10021252127

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 転移性肝平滑筋肉腫切除および動注化学療法後の区域胆管壊死の1剖検例2007

    • Author(s)
      中正恵二, 大山秀樹, 山根木康嗣, 山田直子, 秦正樹, 平野博嗣, 寺田信行, 吉田康彦, 斉藤慎一, 藤元治朗
    • Journal Title

      診断病理 24

      Pages: 77-82

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Poorly differentiated adenocarcinoma with signet-ring cell carcinoma in a hyperplastic polyp of the stomach: report of a case2007

    • Author(s)
      Hirano, H., Yoshida, T., Yoshimura, H., Fukuoka, M., Ohkubo, E., Tachibana, S., Saito, H., Nakasho, K., Nishigami, T
    • Journal Title

      Surg. Today 37

      Pages: 901-904

    • NAID

      10019946731

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pulmonary pleomorphic carcinoma producing hCG2007

    • Author(s)
      Hiroshi Hirano
    • Journal Title

      Pathology International 57

      Pages: 698-702

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory malignant fibrous histiocytoma originating from the intratemporal fossa and extruding into the external auditory meatus2007

    • Author(s)
      Koji Yamanegi
    • Journal Title

      Pathology 39

      Pages: 371-373

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 転移性肝平滑筋肉腫切除および動注化学療法後の区域胆管壊死の1剖検例2007

    • Author(s)
      中正 恵二
    • Journal Title

      診断病理 24

      Pages: 77-82

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 歯周病細菌感染に起因したと考えられる化膿性肝膿瘍の1剖検例2009

    • Author(s)
      大山秀樹, 野杁由一郎, 小越菜保子, 西村英紀, 恵比須繁之
    • Organizer
      第130回日本歯科保存学会2009年度春季学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2009-06-12
    • Related Report
      2009 Final Research Report
  • [Presentation] 産生系の関与2009

    • Author(s)
      大山秀樹, 小越菜保子, 西村英紀, 山根木康嗣, 橋谷進, 木崎久美子
    • Organizer
      第52回春季日本歯周病学会学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2009-05-15
    • Related Report
      2009 Final Research Report
  • [Presentation] 血球貪食症候群が原因と考えられる高度肝壊死の2剖検例2009

    • Author(s)
      中正恵二, 山根木康嗣, 大山秀樹, 西岡稔浩, 平野博嗣, 沖村明, 山田直子, 秦正樹, 山根順子, 小越菜保子, 寺田信行
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-02
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 歯周病-感染性疾患として全身に及ぼす影響-2008

    • Author(s)
      大山秀樹
    • Organizer
      第42回日本病理学会近畿支部学術集会
    • Place of Presentation
      西宮
    • Year and Date
      2008-09-06
    • Related Report
      2009 Final Research Report
  • [Presentation] 臓に移植された肝細胞の胆管上皮細胞への分化2008

    • Author(s)
      秦正樹, 渡邊博文, 大山秀樹, 山田直子, 山根木康嗣, 小越菜保子, 山根順子, 中正恵二, 寺田信行
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-16
    • Related Report
      2009 Final Research Report
  • [Presentation] 肝内限局型原発性硬化性胆管炎の2切除例2008

    • Author(s)
      中正恵二, 平野博嗣, 沖村明, 柴垣昌史, 大山秀樹, 山根木康嗣, 山田直子, 秦正樹, 山根順子, 寺田信行, 覚野綾子, 安井智明, 山中若樹
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-15
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 膵腫瘍の一切除例2007

    • Author(s)
      平野博嗣, 沖村明, 中正恵二, 寺田信行, 西上隆之
    • Organizer
      第38回日本病理学会近畿支部学術集会
    • Place of Presentation
      西宮
    • Year and Date
      2007-09-08
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 歯周炎感受性に関する免疫遺伝学的アプローチ-ハンセン病を疾患モデルとして捉えた研究-2007

    • Author(s)
      大山秀樹
    • Organizer
      第18回日本口腔病理学会総会・学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2007-08-11
    • Related Report
      2009 Final Research Report
  • [Presentation] 多発性肝転移を呈した胃腫瘍の1例2007

    • Author(s)
      中正恵二, 西上隆之, 木崎智彦
    • Organizer
      第37回日本病理学会近畿支部学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-06-02
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Book] 解明病理学2009

    • Author(s)
      中正恵二
    • Publisher
      医歯薬出版
    • Related Report
      2009 Final Research Report
  • [Book] 触明病理学2009

    • Author(s)
      中正恵二
    • Total Pages
      827
    • Publisher
      医歯薬出版
    • Related Report
      2009 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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