Functional role of inhibitory neurons in the signal processing of the trigeminal pain
| Project/Area Number |
19603015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Uekusa Gakuen University (2008-2009)
Teikyo University (2007) |
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Principal Investigator |
KUWANA Shun-ichi Uekusa Gakuen University, 保健医療学部, 教授 (70129998)
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| Co-Investigator(Kenkyū-buntansha) |
HOSOKAWA Yuki 慶應義塾大学, 医学部, 助手 (00348765)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 三叉神経痛 / 三叉神経脊髄路核尾側亜核 / 遺伝子操作マウス / ガンマアミノ酪酸 / 疼痛 / 三叉神 / 三叉神経脊髄路核 / ニューロン / マウス / 膜電位感受性色素 / 膜電位イメージング法 / 三叉神経 / 痛み / GABA / シナプス / 遺伝子改変 |
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| Research Abstract |
We found that inhibitory GABAergic neurons in the trigeminal subnucleus caudalis (Sp5C) of GAD67-GFP knock-in mouse received exclusively excitatory postsynaptic inputs, and were characterized by multipolar-shaped somata. Furthermore, we showed that an analgesic action of carbamazepine resulted from the large depression of non-GABAergic neuron in the Sp5C compared with that of GABAergic neuron.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] CO2-sensitivity of GABAergic neurons in the ventral medullary surface of GAD67-GFP knock-in neonatal mice.2008
Author(s)
Kuribayashi J, Sakuraba S, Hosokawa Y, Hatori, E, Tsujita, M, Takeda, J, Yanagawa, Y, Obata K, Kuwana S
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Journal Title
Adv Exp Med Biol 605
Pages: 338-42
Related Report
Peer Reviewed
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