| Budget Amount *help |
¥115,180,000 (Direct Cost: ¥88,600,000、Indirect Cost: ¥26,580,000)
Fiscal Year 2011: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2010: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2009: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2008: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2007: ¥22,880,000 (Direct Cost: ¥17,600,000、Indirect Cost: ¥5,280,000)
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| Research Abstract |
We clarified that two bHLH transcription factors(TFs), Math1 and Ptf1a, are involved in specifying the spatial identities of neural stem cells in the cerebellar primordium. We also found similar roles for these TFs in the hindbrain. Neural stem cells in the Ptf1a-expressing ventricular zone change their temporal identity ; while they produce Purkinje cells at early stages, they become to generate Pax2 positive interneurons at late stages. We clarified that two TFs, Olig2 and Gsh1, are involved in regulating temporal identity of neural stem cells in the cerebellar ventricular zone.
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