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Identification of a novel nutrient signal related on health and longevity : role in the prevention of common diseases.

Research Project

Project/Area Number 19680030
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Applied health science
Research InstitutionThe University of Tokushima

Principal Investigator

TAKETANI Yutaka  The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 准教授 (30263825)

Research Collaborator SHUTO Emi  徳島大学, 大学院・栄養生命科学教育部, 大学院生
TANAKA Rieko  徳島大学, 大学院・栄養生命科学教育部, 大学院生
WATARI Eriko  徳島大学, 大学院・栄養生命科学教育部, 大学院生
KITAMURA Tomoyo  徳島大学, 大学院・栄養生命科学教育部, 大学院生
SHIOTA Asuka  徳島大学, 大学院・栄養生命科学教育部, 大学院生
TAN Vu van  徳島大学, 大学院・栄養生命科学教育部, 大学院生
UEBANSO Takashi  徳島大学, 大学院・栄養生命科学教育部, 大学院生
AMO Kikuko  徳島大学, 大学院・栄養生命科学教育部, 大学院生
TANIMURA Ayako  徳島大学, 大学院・栄養生命科学教育部, 大学院生
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2007: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywordsシグナル伝達 / リン / 血管内皮細胞 / 高リン血症 / 心血管疾患 / 慢性腎臓病 / 予防栄養学 / 血管内皮機能 / 血管内皮
Research Abstract

Nutrients and their metabolites are balanced within adequate levels to maintain normal physiological functions. Impairment of the balance of nutrient metabolism by unfavorable diet causes life-style related diseases such as diabetes, cardiovascular disease, etc. In this research, we investigated the role of nutrient signal, especially focused on "phosphate signal" that is closely related on aging and some life-style related diseases. Hyperphosphatemia caused by high phosphate intake can induce endothelial dysfunction through the phosphate signal, and it would be a risk factor for cardiovascular cliseaSe.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (47 results)

All 2010 2009 2008 2007

All Journal Article (24 results) (of which Peer Reviewed: 24 results) Presentation (19 results) Book (4 results)

  • [Journal Article] Dietary phosphorus acutely impairs endothelial function.2009

    • Author(s)
      Shuto E, Taketani Y, Tanaka R, Harada N, Isshiki M, Sato M, Nashiki K, Arno K, Yamamoto H, Higashi Y, Nakaya Y, Takeda E.
    • Journal Title

      J Am Soc Nephrol 20(7)

      Pages: 1504-1512

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypocaloric high protein diet improves fatty liver and hypertriglyceridemia in sucrose-fed obese rats via two pathways.2009

    • Author(s)
      Uebanso T, Taketani Y, Fukaya M, Sato K, Takei Y, Sato T, Sawada N, Arno K, Harada N, Arai H, Yamamoto H, Takeda E.
    • Journal Title

      Am J Physiol Endocrinol Metab 297(1)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stanniocalcin 2 is positively and negatively controlled by 1, 25(OH)(2)D(3) and PTH in renal proximal tubular cells.2009

    • Author(s)
      Takei Y, Yamamoto H, Masuda M, Sato T, Taketani Y, Takeda E.
    • Journal Title

      J Mol Endoclinol 42

      Pages: 261-268

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of cis-acting promoter sequences required for expression of the glycerol-3-phosphate acyltransferase 1 gene in mice.2009

    • Author(s)
      Yoshida M, Harada N, Yamamoto H, Taketani Y, Nakagawa T Yin Y, Hattori A, Zenitani T, Hara S, Yonemoto H, Nakamura A, Nakano M, Mawatari K, Teshigawara K, Arai H, Hosaka T, Takahashi A, Yoshimoto K, Nakaya Y.
    • Journal Title

      Biochim Biophys Acta 1791

      Pages: 39-52

    • NAID

      120006631417

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dose-dependent effects of barley cooked with white rice on postprandial glucose and desacyl ghrelin levels.2009

    • Author(s)
      Sakuma M, Yamanaka-Okumura H, Naniwa Y, Matsumoto D, Tsunernatsu M, Yamamoto H, Taketani Y, Takeda E.
    • Journal Title

      J Clin Biochem Nutr 44

      Pages: 151-159

    • NAID

      130004879165

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary phosphorus acutely impairs endothelial function.2009

    • Author(s)
      Shuto E, et al.
    • Journal Title

      Journal of American Society of Nephrology 20

      Pages: 1504-1512

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypocaloric high-protein diet improves fatty liver and hypertriglyceridemia in sucrose-fed obese rats via two2009

    • Author(s)
      Uebanso T, et al.
    • Journal Title

      American Journal of Physiology 297

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of glucose metabolism in patients with impaired glucose tolerance or diabetes by long-term administration of a palatinose-based liqurd formula as a part of breakfast.2009

    • Author(s)
      Sakuma M, et al.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition 45

      Pages: 155-162

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dose-dependent effects of barley cooked with white rice on postprandial glucose and desacyl ghrelin levels2009

    • Author(s)
      Sakuma M, et.al.
    • Journal Title

      J Clin Biochem Nutr. 44

      Pages: 151-159

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stanniocalcin 2 is positively and negatively controlled by 1, 25(OH)2D3 and PTH in renal proximal tubular cells2009

    • Author(s)
      Takei Y, et.al.
    • Journal Title

      J Mol Endocrinol 42

      Pages: 261-268

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Palatinose and oleic acid act together to prevent pancreatic islet disruption in nondiabetic obese Zucker rats.2008

    • Author(s)
      Sato K, Arai H, Miyazawa Y, Fukaya M, Uebanso T, Koganei M, Sasaki H, Sato T, Yamamoto H, Taketani Y, Takeda E.
    • Journal Title

      J Med Invest 55

      Pages: 183-195

    • NAID

      130004465140

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Naito and viscous vegetables in a Japanese style meal suppress postprandial glucose and insulin responses.2008

    • Author(s)
      Taniguchi A, Yamanaka-Okumura H, Nishida Y, Yamamoto H, Taketani Y, Takeda E.
    • Journal Title

      Asia Pac J Clin Nutr 17

      Pages: 663-668

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Natto and viscous vegetables in a Japanese style meal suppress postprandial glucose and insulin responses2008

    • Author(s)
      Taniguchi A, et.al.
    • Journal Title

      Asia Pac J Clin Nutr 17

      Pages: 663-668

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parathyroid hormone dependent endocytosis of renal type Be Na/Pi cotransporter.2007

    • Author(s)
      Segawa H, Yamanaka S, Onitsuka A, Tomoe Y, Kuwahata M, Ito M, Taketani Y, Miyamoto KT.
    • Journal Title

      Am J Physfol Renal Physiol 292(1)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a palatinose-based liquid diet (Inslow) on glycemic control and the second-meal effect in healthy men.2007

    • Author(s)
      Arai H, Mizuno A, Sakuma M, Fukaya M, Ivlatsuo K, Muto K, Sasaki H, Matsuura M, Okumura H, Yamamoto H, Taketani Y, Doi T, Takeda E.
    • Journal Title

      Metabolism 56(1)

      Pages: 115-121

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Advantage of low glycemie index and low phosphate diet on diabetic nephropathy and aging-related diseases.2007

    • Author(s)
      Taketani Y, Shuto E, Nishida Y, Tanaka R.
    • Journal Title

      J Med Invest 54

      Pages: 359-365

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Caveolin-1 in extracellular matrix vesicles secreted from osteoblasts.2007

    • Author(s)
      Sawada N, Taketani Y, Amizuka N, Ichikawa M, Ogawa C, Nomoto K, Nashiki K, Sato K, Arai H, Isshiki M, Segawa H, Yamamoto H, Miyamoto K, Takeda E.
    • Journal Title

      Bone 41(1)

      Pages: 52-58

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Prolonged High Phosphorus Diet on Phosphonis and Calcium Balance in Rats.2007

    • Author(s)
      Tani Y, Sato T, Yamanaka-Okumura H, Yamamoto H, Arai H, Sawada N, Genjida K, Taketani Y, Takeda E.
    • Journal Title

      J Clin Biochem Nutr 40(3)

      Pages: 221-228

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary Palatinose and Oleic Acid Ameliorates Disorders of Glucose and Lipid Metabolism in Zucker Fatty Rats.2007

    • Author(s)
      Sato K, Arai H, Mizuno A, Fukaya M, Sato T, Koganei M, Sasaki H, Yamamoto H, Taketani Y, Doi T, Takeda E.
    • Journal Title

      J Nutt. 137(8)

      Pages: 1908-1915

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of rapid-phase insulin response to elevation of portal glucose concentration.2007

    • Author(s)
      Fukaya M, Mizuno A, AraiH, Muto K, Uebanso T, Matsuo K, Yamamoto H, Taketani Y, Doi T, Takeda E.
    • Journal Title

      Am J Physiol Endocrinel Metah 293(2)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of cell-surface ATP synthase in flow-induced ATP release by vascular endothelial cells.2007

    • Author(s)
      Yamamoto K, Shimizu N, Obi S, Kumagaya S, Taketani Y, Kamiya A, Ando J.
    • Journal Title

      Am J Physiol Heart Circ Physiol 293(3)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary palatinose and oleic acid ameliorates disorders of glucose and lipidMetabolism in Zucker Fatty Rats.2007

    • Author(s)
      Sato K
    • Journal Title

      Journal of Nutrition 137

      Pages: 1908-1915

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of rapid-phase insulin response to elevation of portalglucose concentration.2007

    • Author(s)
      Fukaya M
    • Journal Title

      American Journal of Physiology 293

      Pages: 515-522

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parafibromin tumor suppressor enhances cell growth in the cellsExpressing SV40 large T antigen.2007

    • Author(s)
      Iwata T
    • Journal Title

      Oncogene 26

      Pages: 6176-6183

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] リン血症と心血管疾患:血管機能障害におけるリン摂取の問題2010

    • Author(s)
      竺谷豊高
    • Organizer
      腎臓病と栄養-代謝・食事フォーラム2010
    • Place of Presentation
      東京都
    • Year and Date
      2010-03-27
    • Related Report
      2009 Final Research Report
  • [Presentation] Sodium-dependent phosphate transporter and cardiovascular disease2010

    • Author(s)
      Yutaka Taketani
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山市
    • Related Report
      2009 Final Research Report
  • [Presentation] Sodium-dependent phosphate transporter and cardiovascular disease2010

    • Author(s)
      Yutaka Taketani
    • Organizer
      日本薬学会第130年会(シンポジウム・招待講演)
    • Place of Presentation
      岡山市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Over-Intake of Dietary Phosphorus Accelerates Progression of Atherosclerotic Lesions in Apolipoprotein E Deficient2009

    • Author(s)
      Asuka Shiota, Yutaka Taketani, Ayako Tanimura, Hironori Yamamoto, Eiji Takeda
    • Organizer
      Mice 42nd Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego, California, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Excessive Dietary Phosphorus Acutely Impairs Endothelial Function in Healthy Men.2009

    • Author(s)
      Emi Shuto, Yutaka Taketani, Wakana Kusunose, Terumi Tanaka, Daisuke Eerie, Kikuko Amo, Hironori Yamamoto, Tohru Sakai, Eiji Takeda
    • Organizer
      42nd Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego, California, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Fluctuation of Serum Phosphorus Levels Impairs Endothelial Function in Rats.2009

    • Author(s)
      Eriko Watari, Tormoyo Kitamura, Yutaka Taketani, Ayako Tanimura, Asuka Shiota, Enai Shuto, Tan Vu Van, Hironori Yamamoto, Eiji Takeda
    • Organizer
      42nd Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego, California, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Dual Role of Type III Sodium-Dependent Phosphate Transporter in the Pathogenesis of Arteriosclerosis Caused by Hyperphosphatemia.2009

    • Author(s)
      Takatani Y, Shuto E, Shiota A, Tanimura A, Watari E, Kitamura Yamamoto H, Takeda E.
    • Organizer
      31st. Annual Meeting of American Society of Bone and Mineral Research
    • Place of Presentation
      Denver, Colorado, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Acute effect of elevation of serum phosphorus on endothelial function with reference to oxidative stress and NO production.2009

    • Author(s)
      Taketani Y, Shuto E, Shiota A, Watari E, Kitamura T, HaradaN, Nakaya Y, Miyamoto K, Takeda E.
    • Organizer
      36th International Congress of Physiological Sciences
    • Place of Presentation
      京都市
    • Related Report
      2009 Final Research Report
  • [Presentation] Sodium-dependent phosphate transporter in the cardiovascular dysfunction.2009

    • Author(s)
      Taketani Y, Shuto E, Tanaka R, Isshiki M, Miyamoto K, Takeda E.
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜市
    • Related Report
      2009 Final Research Report
  • [Presentation] Hyperphosphatemia Mediates Oxidative Stress in Bovine Aortic Endothelial Cells2009

    • Author(s)
      Shuto E, Taketani Y. Tanaka R, Tanimura A, Isshiki M, Harada N, Yamamoto H, Takeda E.
    • Organizer
      29th Annual Meeting of American Scociety for Bone and Mineral Research
    • Place of Presentation
      Honolulu, Hawai, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Dual Role of Type III Sodium-Dependent Phosphate Transporter in the Pathogenesis of Arteriosclerosis Caused by Hyperphosphatemia.2009

    • Author(s)
      Yutaka Taketani
    • Organizer
      31st Annual Meeting of American Society of Bone and Mineral Research
    • Place of Presentation
      Denver, Colorado, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Excessive Dietary Phosphorus Acuterly Impairs Endothelial Function in Healthy Men2009

    • Author(s)
      Emi Shuto
    • Organizer
      42nd Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego, California, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fluctuation of Serum Phosphorus Levels Impairs Endothelial Function in Rats2009

    • Author(s)
      Eriko Watari
    • Organizer
      42nd Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego, California, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Over-Intake of Dietary Phosphorus Accelerates Progression of Atheroscle rotic Lesions in Apolipoprotein E Deficient Mice2009

    • Author(s)
      Asuka Shiota
    • Organizer
      42nd Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego, California, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Sodium-dependent phosphate transporter in the cardiovascular dysfunction2008

    • Author(s)
      Taketani Y, et.al.
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effects of Postprandial Hyperphosphatemia on Endothelial Function.2008

    • Author(s)
      Yutaka Taketani, Emi Shuto, Rieko Tanaka, Masashi Isshiki, Kikuko Amo, Hironori Yamamoto, Ken-ichi Miyamoto, Eiji Takeda
    • Organizer
      41nd Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Philadelphia, Pennsylvania, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Mutation of Type IIc Na+-Dependent Phosphate Cotransporter (NaPPi-IIc) and Hereditary Hypophosphatemic Rickets with Hypercalciuria (HHRH)2008

    • Author(s)
      Mikiko Ito, Aya Sakurai, Akiko Ohi, Keiji Hayashi, Takashi Nishiyama, Natsumi Kangawa, Sakiko Sugino, Sawako Tatsumi, Hiroko Segawa, Yutaka Taketani, Ken-ichi Miyamoto
    • Organizer
      41nd Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Philadelphia, Pennsylvania, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Postprandial Hyperphosphatemia is a Novel Risk Factor for Cardiovascular Disease by Involving Endothelial Dysfunction.2008

    • Author(s)
      Shuto E, Taketani Y, Tanaka R, Tanimura A, Uebanso T, Isshiki M, Harada N, Yamamoto H, Nakaya Y, Takeda E.
    • Organizer
      30th Annual Meeting of American Scociety for Bone and Mineral Research
    • Place of Presentation
      Montreal, Quebec, Canada
    • Related Report
      2009 Final Research Report
  • [Presentation] Hyperphosphatemia mediates oxidative stress in bovine aortic endothelial cells.2007

    • Author(s)
      Shuto E
    • Organizer
      29th Annual meeting of American Society forBone and Mineral Research
    • Place of Presentation
      ホノルル、米国ハワイ州
    • Year and Date
      2007-09-17
    • Related Report
      2007 Annual Research Report
  • [Book] リントランスポ-タ-と疾患」最新トランスポーター研究2009(編集1杉山雄一、金井好克)2009

    • Author(s)
      宮本賢一, 瀬川博子、伊藤美紀子、辰巳佐和子
    • Publisher
      株式会社メディカルドゥ
    • Related Report
      2009 Final Research Report
  • [Book] 最新トランスポーター研究20092009

    • Author(s)
      宮本賢一, 他
    • Total Pages
      266
    • Publisher
      株式会社メディカルドゥ
    • Related Report
      2009 Annual Research Report
  • [Book] 「栄養素トランスポーターの分子制御とホルモン代謝:リン酸トランスポーターをめぐる話題」トランスポーター科学最前線(総編集:辻彰)2008

    • Author(s)
      宮本賢一、竹谷豊、桑波田雅士、伊藤美紀子、瀬川博子、辰巳佐和子
    • Publisher
      京都廣川書店
    • Related Report
      2009 Final Research Report
  • [Book] トランスポーター科学最前線2008

    • Author(s)
      宮本賢一
    • Total Pages
      374
    • Publisher
      京都廣川書店
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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