Identification of candidate proteins involved in synaptic plasticity by database search and experimental evaluations of their cellular functions

Research Project

Project/Area Number	19700304
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Neuroscience in general
Research Institution	The Institute of Physical and Chemical Research
Principal Investigator	CHIMURA Takahiko The Institute of Physical and Chemical Research, 記憶学習機構研究チーム, 研究員 (90392034)
Project Period (FY)	2007 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥3,800,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥600,000) Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywords	PDZ結合モチーフ / 神経可塑性 / バイオインフォマティクス / シグナル伝達 / 神経 / シナプス後肥厚 / 後シナプス肥厚
Research Abstract	The followings were achieved by this project. 1. PDZ binding motifs are special sequence overrepresented at the C-terminal ends of proteins. 2. Using this information, novel interactions mediated PDZ binding motifs and PDZ domains were identified. 3. Novel membrane proteins expressed in neurons were identified. Interacting proteins with the intracellular portion of these proteins were identified.

Report

(4 results)