Utilization of spontaneous melanoma mice for finding biomarkers

• Project/Area Number: 19700371
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Laboratory animal science
• Research Institution: Chubu University
• Principal Investigator: KAWAMOTO Yoshiyuki Chubu University, 生命健康科学部, 准教授 (10410664)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,700,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥600,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: バイオマーカー / メラノーマ / RET / ケモカイン / プロテオミクス / アルブミン

Research Abstract

RET-transgenic mice, which develop malignant melanoma, are useful for finding biomarkers which express in the serum or urine correlated with tumor progression and/or metastasis. We found that chemokin (C-X-C motif) ligand, CXCL10 and CXCL16 are significantly increased in serum of RET-transgenic mice which has malignant tumor. Our findings suggest that these proteins can be candidates for new biomarkers of melanoma.

Research Products

• [Journal Article] A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation. (2010)
  • Author(s): Kato M, Takeda K, Hossain K, Thang ND, Kaneko Y, Kumasaka M, Yamanoshita O, Uemura N, Takahashi M, Ohgami N, Kawamoto Y.
  • Journal Title: J Cell Biochem. 110(2) Pages: 399-407
  • Peer Reviewed
• [Journal Article] A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation (2010)
  • Author(s): Kato M.et al.
  • Journal Title: J Cell Biochem (In press)
  • Peer Reviewed
• [Journal Article] 1, 4-butanediyl-bismethanethiosulfonate (BMTS) induces apoptosis through reactive oxygen species-mediated mechanism. (2009)
  • Author(s): Hossain K, Kawamoto Y, Hamada M, Akh, AA, Yanagishita T, Hoque MA, Tsuboi H, Kato M, Nakashima I.
  • Journal Title: J Cell Biochem. 108(5) Pages: 1059-65
  • Peer Reviewed
• [Journal Article] 1, 4-butanediyl-bismethanethiosulfonate(BMTS)induces apoptosis through reactive oxygen species-mediated mechanism (2009)
  • Author(s): Hossain K.et al.
  • Journal Title: J Cell Biochem 108 Pages: 1059-1065
  • Peer Reviewed
• [Presentation] チオール反応性化合物によるアポトーシス誘導とシグナル伝達機序 (2009)
  • Author(s): 川本善之
  • Organizer: 日本 Cell Death 学会
  • Place of Presentation: 長崎大学医学部
  • Year and Date: 2009-08-01
• [Presentation] チオール反応性化合物によるアポトーシス誘導とシグナル伝達機序 (2009)
  • Author(s): 川本善之
  • Organizer: 第18回日本アポトーシス研究会学術集会
  • Place of Presentation: 長崎大学
• [Presentation] ヒ素による細胞膜脂質ラフトを介する活性酸素産生機序の解析 (2008)
  • Author(s): 川本善之
  • Organizer: BMB2008
  • Place of Presentation: 神戸ポートアイランド
• [Remarks]
  • URL: http://www.chubu.ac.jp/english/faculty/profile/adeaa0e37067535f144217de609ba58430b7c6b5.html
• [Remarks]
  • URL: http://web.mac.com/chubu5011/iWeb/English%20page/Introduction.html