Identification of Autotomy-Promoting Factor from Sea stars and Molecular mechanism of Autotomy

• Project/Area Number: 19710190
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Living organism molecular science
• Research Institution: Tohoku Pharmaceutical University
• Principal Investigator: UKAI Kazuyo Tohoku Pharmaceutical University, 薬学部, 助教 (60433512)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,930,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥630,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: マヒトデ / Asterias amurensis / 自切 / 自切誘起因子 / APF / ニコチンアミド / N-メチルキノリン酸 / NMDA受容体 / Astreias amurensis

Research Abstract

Japanese Asterias amurensis is known to have this ability of autotomy. The body fluids of scalded A.amurensis induced an arm autotomy of the intact A.amurensis by intracoelomic injection in an arm. A mixture of nicotinamide and N-methylquinolinic acid (NMQA) were assigned in this fraction as the inducers of autotomy. NMQA has been revealed to be a substrate of NMDA glutamate receptor.

Research Products

• [Presentation] マヒトデ(Asterias amurensis)の自切の分子機構におけるN-メチルキノリン酸の役割 (2011)
  • Author(s): 鵜飼和代, ら
  • Organizer: 日本薬学会第131回年会
  • Place of Presentation: ツインメッセ静岡
  • Year and Date: 2011-03-31
• [Presentation] マヒトデ(Asterias amurensis)の自切の分子機構におけるN-メチルキノリン酸の役割 (2011)
  • Author(s): 鵜飼和代、工藤香澄、浪越通夫
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: ツインメッセ静岡(静岡)
  • Year and Date: 2011-03-31
• [Presentation] Identification of Autotomy-Promoting Factor from Asterias amurensis and Molecular Mechanism of Autotomy (2010)
  • Author(s): Ukai Kazuyo, et al
  • Organizer: PACIFICHEM 2010
  • Place of Presentation: ホノルルコンベンションセンター
  • Year and Date: 2010-12-19
• [Presentation] Identification of Autotomy-Promoting Factor from Asterias amurensis and Molecular Mechanism of Autotomy (2010)
  • Author(s): Kazuyo Ukai, Kasumi Kudou, Sakie Iwasaki, Hiroshi Nagai, Michio Namikoshi
  • Organizer: PACIFICHEM 2010
  • Place of Presentation: Convention Centerハワイ(ホノルル)
  • Year and Date: 2010-12-19
• [Presentation] マヒトデの自切の分子機構 (2010)
  • Author(s): 鵜飼和代, ら
  • Organizer: 第5回化学生態学研究会
  • Place of Presentation: 函館 湯の川プリンスホテル渚亭
  • Year and Date: 2010-06-11
• [Presentation] マヒトデ(Asterias amurensis)の自切の分子機構 (2010)
  • Author(s): 鵜飼和代、永井宏史、浪越通夫
  • Organizer: 第5回化学生態学研究会
  • Place of Presentation: 湯の川プリンスホテル渚亭(北海道)
  • Year and Date: 2010-06-11
• [Presentation] (Asterias amurensis)の自切の分子機構 (2009)
  • Author(s): 鵜飼和代, ら
  • Organizer: 第6回棘皮動物研究集会
  • Place of Presentation: 東京 東京工業大学大岡山キャンパス
  • Year and Date: 2009-12-12
• [Presentation] マヒトデ(Asterias amurensis)の自切の分子機構 (2009)
  • Author(s): 鵜飼和代, ら
  • Organizer: 第6回棘皮動物研究集会
  • Place of Presentation: 東京東 京工業大学大岡山キャンパス
  • Year and Date: 2009-12-12
• [Presentation] マヒトデ(Asterias amurensis)の自切の分子機構 (2009)
  • Author(s): 鵜飼和代, 永井宏史, 浪越通夫
  • Organizer: 第6回棘皮動物研究集会
  • Place of Presentation: 東京東京工業大学大岡山
  • Year and Date: 2009-12-12
• [Presentation] Mechanism of Autotomy of Asterias amurensis (2009)
  • Author(s): Ukai Kazuyo
  • Organizer: The 25th NAITO CONFERENCE on Chemical Biology II-An Emerging Field Inspired
  • Place of Presentation: 札幌 シャトレーゼガトーキングダム
  • Year and Date: 2009-09-09
• [Presentation] Mechanism of Autotomy of Asterias amurensis (2009)
  • Author(s): Ukai Kazuyo
  • Organizer: The 25th NAITO CONFERENCE on Chemical Biology II -An Emerging Field Inspired
  • Place of Presentation: 札幌シャトレーゼガトーキングダム
  • Year and Date: 2009-09-09
• [Presentation] ヒトデの自切の化学(2)マヒトデの自切の分子機構 (2009)
  • Author(s): 鵜飼和代
  • Organizer: 第4回化学生態学研究会
  • Place of Presentation: 函館 湯の川プリンスホテル渚亭
  • Year and Date: 2009-06-13
• [Presentation] ヒトデの自切の化学(2)マヒトデの自切の分子機構 (2009)
  • Author(s): 鵜飼和代
  • Organizer: 第4回化学生態学研究会
  • Place of Presentation: 函館湯の川プリンスホテル渚亭
  • Year and Date: 2009-06-13
• [Presentation] マヒトデ(Asterias amurensis)の自切の分子機構 (2009)
  • Author(s): 鵜飼和代, ら
  • Organizer: 日本薬学会第129回年会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2009-03-27
• [Presentation] マヒトデ(Asterias amurensis)の自切の分子機構 (2008)
  • Author(s): 鵜飼和代, ら
  • Organizer: 第50回天然有機化合物討論会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2008-09-30
• [Presentation] マヒトデ(Asterias amurensis)の自切の分子機構 (2008)
  • Author(s): 鵜飼和代
  • Organizer: 第50回天然有機化合物討論会日本薬学会第129回年会
  • Place of Presentation: 福岡国際会議場京都国際会館
• [Book] Echinoderms : Proceedings from the 12th International Echinoderm Conference (2010)
  • Author(s): Ukai Kazuyo, Nakazawa Takahiro, Namikoshi Michio
  • Publisher: Taylor & Francis
• [Book] Echinoderms:Proceedings from the 12th International Echinoderm Conference (2010)
  • Author(s): Ukai Kazuyo, Nakazawa Takahiro, Namikoshi Michio
  • Publisher: Taylor & Francis