Identification of Autotomy-Promoting Factor from Sea stars and Molecular mechanism of Autotomy
| Project/Area Number |
19710190
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Living organism molecular science
|
|---|
| Research Institution | Tohoku Pharmaceutical University |
|---|
Principal Investigator |
UKAI Kazuyo Tohoku Pharmaceutical University, 薬学部, 助教 (60433512)
|
|---|
| Project Period (FY) |
2007 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,930,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
|---|
| Keywords | マヒトデ / Asterias amurensis / 自切 / 自切誘起因子 / APF / ニコチンアミド / N-メチルキノリン酸 / NMDA受容体 / Astreias amurensis |
|---|
| Research Abstract |
Japanese Asterias amurensis is known to have this ability of autotomy. The body fluids of scalded A.amurensis induced an arm autotomy of the intact A.amurensis by intracoelomic injection in an arm. A mixture of nicotinamide and N-methylquinolinic acid (NMQA) were assigned in this fraction as the inducers of autotomy. NMQA has been revealed to be a substrate of NMDA glutamate receptor.
|
Report
(6 results)
Research Products
(18 results)
