| Project/Area Number |
19770117
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Osaka Medical College |
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Principal Investigator |
YAMAJI Junko Osaka Medical College, 医学部, 講師 (40340559)
|
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| Research Collaborator |
SHIMUZU Tetsunosuke 大阪医科大学, 消化器外科学, 大学院生
INOUE Yoshihiro 大阪医科大学, 消化器外科学, 大学院生
YAMANA Hidenori 大阪医科大学, 消化器外科学, 大学院生
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| Project Period (FY) |
2007 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,050,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥800,000 (Direct Cost: ¥800,000)
|
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| Keywords | 免疫学 / 移植・再生医療 / 遺伝子 / 細胞・組織 / 生体分子 |
|---|
| Research Abstract |
The purpose of this study is to investigate the molecular mechanism and the physiological role of the macrophage MHC receptor (MMR) 1 and MMR2. The gene for MMR protein was found to be conserved in various animals and human, and we succeeded in the isolation of cDNAs encoding the human homologues of mouse MMR1 and MMR2. We found a rule for the expression of mouse MMRs on PBMCs : they express MMRs for nonself MHCs, implying that MMRs might play a physiological important role in allorecognition.
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