Allograft rejection : Study on novel receptors on innate immune cells for the allo-MHCs.
| Project/Area Number |
19770117
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Osaka Medical College |
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Principal Investigator |
YAMAJI Junko Osaka Medical College, 医学部, 講師 (40340559)
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| Research Collaborator |
SHIMUZU Tetsunosuke 大阪医科大学, 消化器外科学, 大学院生
INOUE Yoshihiro 大阪医科大学, 消化器外科学, 大学院生
YAMANA Hidenori 大阪医科大学, 消化器外科学, 大学院生
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,050,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | 免疫学 / 移植・再生医療 / 遺伝子 / 細胞・組織 / 生体分子 |
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| Research Abstract |
The purpose of this study is to investigate the molecular mechanism and the physiological role of the macrophage MHC receptor (MMR) 1 and MMR2. The gene for MMR protein was found to be conserved in various animals and human, and we succeeded in the isolation of cDNAs encoding the human homologues of mouse MMR1 and MMR2. We found a rule for the expression of mouse MMRs on PBMCs : they express MMRs for nonself MHCs, implying that MMRs might play a physiological important role in allorecognition.
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Report
(6 results)
Research Products
(26 results)
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[Journal Article] Transgene Number-dependent, Gene Expression Rate-independent Rejection of D^d-, K^d-, or D^dK^d-Transgened Mouse Skin or Tumor Cells from C57BL/6 (DbKb)Mice.2011
Author(s)
Yoshihiro Inoue, Junko Tashiro-Yamaji, Michihiro Hayashi, Hiroshi Kiyonari, Tetsunosuke Shimizu, Minenori Ibata, Hidenori Yamana, Takahiro Kubota, Nobuhiko Tanigawa, Ryotaro Yoshida.
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Journal Title
Microbiology and Immunology in press
NAID
Related Report
Peer Reviewed
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[Presentation] Isolation and characterization of a cDNA encoding a novel MHC receptor, macrophage MHC receptor(MMR) 2, in mouse and human.2009
Author(s)
Junko Tashiro-Yamaji, Ryotaro Yoshida, Tetsunosuke Shimizu, Michihiro Hayashi, Yoshihiro Inoue, Minenori Ibata, Hiromi Nakanishi, Yoshiaki Mori, Nobuhiko Tanigawa, Takahiro Kubota.
Organizer
第36回国際生理学会(IUPS2009)
Place of Presentation
国立京都国際会館(京都府京都市)
Year and Date
2009-07-31
Related Report
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