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Development of the antibody drug for prevention and treatment against alveolar echinococcosis

Research Project

Project/Area Number 19780228
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied veterinary science
Research InstitutionHokkaido Institute of Public Health

Principal Investigator

GOTO Akiko  Hokkaido Institute of Public Health, 感染症センター生物科学部, 研究職員 (60414322)

Research Collaborator YAMANO Kimiaki  北海道立衛生研究所, 感染症センター生物科学部, 感染病理科長 (40435566)
YAGI Kinpei  北海道立衛生研究所, 感染症センター生物科学部, 主任研究員 (70414323)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,180,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywords人獣共通感染症 / 多包性エキノコックス症 / 抗体医薬 / 寄生虫 / 多包条虫 / 分子生物学
Research Abstract

Alveolar echinococcosis, which is caused by the larva of E. multilocularis (Em), is a life-threatening zoonotic parasitosis in humans. To develop the diagnosis and antibody drug for treatment against alveolar echinococcosis, I tried to construct some recombinant monoclonal antibodies from Em-infected mouse by using molecular biological methods. In result, four recombinant monoclonal antibodies reacting with Em antigen were constructed.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (11 results)

All 2010 2009 2008

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (4 results)

  • [Journal Article] Serological reactivity of patients with Echinococcus infections (E. granulosus, E. vogeli, and E. multilocularis) against three antigen B subunits2010

    • Author(s)
      Mario L. de la Rue, Kimiaki Yamano, Cybele E. Almeida, Margarete P. Iesbich, Cloe D. Fernandes, Akiko Goto, Hirokazu Kouguchi, Kenichi Takahashi
    • Journal Title

      Parasitology Research 106

      Pages: 741-745

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diagnosis of alveolar echinococcosis using immunoblotting with plural low molecular weight antigens2009

    • Author(s)
      Kimiaki Yamano, Akiko Goto, Masahiro Miyoshi, Koji Furuya, Yukiharu Sawada, Naoki Sato
    • Journal Title

      Journal of Helminthology 83

      Pages: 57-61

    • Related Report
      2009 Annual Research Report 2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Galβ1-6Gal antigenic epitope which accounts for serological cross-reaction in diagnosis of Echinococcus multilocularis infection2009

    • Author(s)
      Kimiaki Yamano, Akiko Goto, Fukumi Nakamura-Uchiyama, Yukifumi Nawa, Noriyasu Hada, Tadahiro Takeda
    • Journal Title

      Parasite Immunology 31

      Pages: 481-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Japanese monkey (Macaca fuscata) with alveolar echinococcosis after treatment with albendazole for 10 years: serodiagnosis and determination of albendazole metabolites2009

    • Author(s)
      Kimiaki Yamano, Akio Kanetoshi, Akiko Goto, Miori Kishimoto, Nobuyuki Kobayashi, Satoshi Fujimoto, Kazutaka Yamada
    • Journal Title

      Parasitology Research 106

      Pages: 69-74

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gal β 1-6Gal antigenic epitope which accounts for serological cross-reaction in diagnosis of Echinococcus multilocularis infection2009

    • Author(s)
      Kimiaki Yamano, Akiko Goto, Fukumi Nakamura-Uchiyama, Yukifumi Nawa, Noriyasu Hada, Tadahiro Takeda
    • Journal Title

      Parasite Immunology 31

      Pages: 481-487

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japanese monkey(Macaca fuscata)with alveolar echinococcosis after treatment with albendazole for 10 years : serodiagnosis and determination of albendazole metabolites2009

    • Author(s)
      Kimiaki Yamano, Akio Kanetoshi, Akiko Goto, Miori Kishimoto, Nobuyuki Kobayashi, Satoshi Fujimoto, Kazutaka Yamada
    • Journal Title

      Parasitology Research 106

      Pages: 69-74

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of emY162 encoding an immunogenic protein cloned from an adult worm-specific cDNA library of Echinococcus multilocularis2008

    • Author(s)
      Yoshinobu Katoh, Hirokazu Kouguchi, Jun Matsumoto, Akiko Goto, Tomohiro Suzuki, Yuzaburo Oku, Kinpei Yagi
    • Journal Title

      Biochimica et Biophysica Acta 1780

      Pages: 1-6

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] 遺伝子工学的手法を用いた多包虫に対する組換えモノクローナル抗体の作製と性状解析2009

    • Author(s)
      後藤明子、八木欣平、山野公明
    • Organizer
      第148回日本獣医学会学術集会
    • Place of Presentation
      とりぎん文化会館(鳥取県鳥取市)
    • Year and Date
      2009-09-25
    • Related Report
      2009 Final Research Report
  • [Presentation] 遺伝子工学的手法を用いた多包虫に対する組換えモノクローナル抗体の作成と性状解析2009

    • Author(s)
      後藤明子、山野公明、八木欣平
    • Organizer
      第148回日本獣医学会学術集会
    • Place of Presentation
      とりぎん文化会館(鳥取県鳥取市)
    • Year and Date
      2009-09-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 遺伝子工学的手法を用いた多包虫に対する組換えモノクローナル抗体の作製2009

    • Author(s)
      後藤明子、八木欣平、山野公明
    • Organizer
      第78回日本寄生虫学会大会
    • Place of Presentation
      法政大学市ヶ谷キャンパス(東京都千代田区)
    • Year and Date
      2009-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 遺伝子工学的手法を用いた多包虫に対する組換えモノクローナル抗体の作成2008

    • Author(s)
      後藤明子
    • Organizer
      第78回に本寄生虫学会大会
    • Place of Presentation
      東京都千代田区・法政大学市ヶ谷キャンパス
    • Year and Date
      2008-03-28
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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