Development on new methodology for optical resolution using plant glycosyltransferases and its pharmacological exploitation
| Project/Area Number |
19790018
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Oita University |
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Principal Investigator |
SHIMODA Kei Oita University, 医学部, 准教授 (40284153)
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| Project Period (FY) |
2007 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | 有機合成化学 / バイオテクノロジー / 酵素 / 有機化学 / タンパク質 / 酵素反応 |
|---|
| Research Abstract |
A plant xylosyltransferase was isolated from cultured plant cells by chromatographies using ion-exchange column, affinity column, and size excluding column. The new enzymatic resolution of (RS)-1-phenylalkyl β-D-glucosides has been achieved by stereoselective xylosylation with the enzyme to give (R)-1-phenylalkyl β-primeverosides and unreacted (S)-1-phenylalkyl β-D-glucosides with high diastereoselectivity.
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Report
(6 results)
Research Products
(40 results)
