| Project/Area Number |
19790066
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
MATSUNAGA Toshiyuki Gifu Pharmaceutical University, 薬学部, 准教授 (80306274)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,490,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | リポタンパク質 / 酸化 / 動脈硬化症 / 酸化ストレス |
|---|
| Research Abstract |
Treatment with inflammatory markers at concentrations which are detected in atheromatous plaques less affected the viabilities of vascular cells such as endothelial cells and smooth muscle cells. In the binding affinity for the marker proteins, no significant difference was observed between un-oxidized and oxidized lipoproteins, whereas the oxidative modification of lipoprotein in the presence of the markers resulted in an increase in the maker-lipoprotein conjugates and a slight decrease in the oxidized apoprotein. In addition, the conjugates were less susceptible to endothelial cells than oxidized lipoproteins prepared without inflammatory marker, suggesting the involvement of the marker in the suppressive mechanism of atherogenesis.
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