Elucidation of the functional role of 5-HT_7 receptors on the formative or disruptive mechanisms of stress adaptation
| Project/Area Number |
19790069
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
TSUJI Minoru International University of Health and Welfare, 薬学部, 准教授 (70297307)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | ストレス / 適応 / 5-HT_7受容体 / ERK / マウス / ストレス性精神疾患 / 滴応 / セロトニン(5-HT) |
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| Research Abstract |
Intracerebroventricular (i.c.v.) injection of the selective 5-HT_7 receptor antagonist disrupted the ability of mice to adapt to stress, and then induced the abnormal behaviors that reflect the low anxiety and/or high impulsivity. Also, increases in 5-HT_7 receptor proteins as well as ERK phosphorylation were observed in mice that have been adapted to stress. These biochemical changes disappeared in mice that have not been adapted to stress by i.c.v. injection of the selective 5-HT_7 receptor antagonist. It is therefore suggested that brain 5-HT_7 receptor-ERK system may play an important role on the mechanisms of stress adaptation.
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Report
(4 results)
Research Products
(21 results)
