Analysis of 24-hydroxycholesterol as a biomarker of Alzheimer's disease and target of the medicine for Alzheimer's disease.
| Project/Area Number |
19790142
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Nigata University of Phermacy and Applied Life Sciences |
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Principal Investigator |
NAKAGAWA Saori Nigata University of Phermacy and Applied Life Sciences, 薬学部, 助教 (30410228)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | 24S-ヒドロキシコレステロール / アルツハイマー病 / 細胞毒性 / GC-MS / サロゲートマーカー / ポリフェノール / 24-ヒドロキシコレステロール / 痴呆 / 脳神経疾患 / 薬学 |
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| Research Abstract |
A simple pretreatment method for the determination of 24S-hydroxycholesterol as a surrogate marker of Alzheimer disease in human plasma and human cerebrospinal fluid by gas chromatography/mass spectrometry (GC/MS) has been developed. It was found a tendency that the concentration levels of 24S-hydroxycholesterol and amyroid・in plasma with Lewy patients have been decreased. Futhermore, we investigate 24S-hydroxycholesterol-mediated cytotoxicity for SH-SY5Y cells, and also explore the anti-cytotoxicity agents. We found the polyphenols from Japanese tea have an anti-cytotoxicitic effect.
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Report
(4 results)
Research Products
(74 results)
