Gene expression profile of gastric cancer with gastric and intestinal phenotype
| Project/Area Number |
19790261
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Hiroshima University |
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Principal Investigator |
OUE Naohide Hiroshima University, 大学院・医歯薬総合研究科, 講師 (60346484)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | 腫瘍 / 胃癌 / 形質発現 / HOXA10 / GJP6 / HOXA 10 / GJB6 |
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| Research Abstract |
本研究では、胃型・腸型形質を有する胃癌に関連している遺伝子を同定することを目的とした。腸型形質の胃癌で発現している遺伝子として、HOXA10とGJP6を同定した。免疫染色を行った結果、HOXA10は52%、GJP6は22%の胃癌で発現しており、腸型形質の胃癌で染色された。特にGJP6は、ギャップ結合を構成する膜貫通蛋白質であるコネキシン30をコードする遺伝子であり、治療標的として有用である。
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Report
(3 results)
Research Products
(77 results)
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[Journal Article] Immunohistochemical analysis of Reg IV in urogenital organs : Frequent expression of Reg IV in prostate cancer and potential utility as serum tumor marker2009
Author(s)
Hayashi T, Matsubara A, Ohara S, Mita K, Hasegawa Y, Usui T, Arihiro K, NorimuraS, Sentani K, Oue N, Yasui W
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Journal Title
Oncol Rep 21
Pages: 95-100
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Peer Reviewed
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[Journal Article] Reg IV is an independent prognostic factor for relapse in patients with clinically localized prostate cancer2008
Author(s)
Ohara S, Oue N, Matsubara A, Mita K, Hasegawa Y, Hayashi T, Usui T, Amatya VJ, Takeshima Y, Kuniyasu H, Yasui W
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Journal Title
Cancer Sci 99
Pages: 1570-1577
Related Report
Peer Reviewed
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[Journal Article] High mobility group box-1-inducible melanoma inhibitory activity is associated withm nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma2008
Author(s)
Sasahira T, Kirita T, Oue N, Bhawal UK, Yamamoto K, Fujii K, Ohmori H, Luo Y, Yasui W, Bosserhoff AK, Kuniyasu H
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Journal Title
Cancer Sci 99
Pages: 1806-1812
Related Report
Peer Reviewed
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[Journal Article] Immunohistochemical staining of Reg IV and claudin-18 is useful in the diagnosis of gastrointestinal signet ring cell carcinoma2008
Author(s)
Sentani K, Oue N, Tashiro T, Sakamoto N, Nishisaka T, Fukuhara T, Taniyama K, Matsuura H, Arihiro K, Ochiai A, Yasui W
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Journal Title
Am J Surg Pathol 32
Pages: 1182-1189
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Peer Reviewed
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[Journal Article] Overexpression of RegIV in peritoneal dissemination of gastric cancer and its potential as A novel marker for the detection of peritoneal micrometastasis2008
Author(s)
Miyagawa K, Sakakura C, Nakashima S, Yoshikawa T, Fukuda K, Kin S, Nakase Y, Shimomura K, Oue N, Yasui W, Hayasizaki H, Okazaki Y, Yamagishi H, Hagiwara A, Otsuji E
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Journal Title
Anticancer Res 28
Pages: 1169-1179
Related Report
Peer Reviewed
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[Journal Article] Serum olfactomedin 4 (GW112, hGC-1)incombination with Reg IV is a highly sensitive biomarker for gastric cancer.
Author(s)
Oue N, Sentani K, Noguchi T, Ohara S,Sakamoto N, Hayashi T, Anami K, Motoshita J, Ito M, Tanaka S, Yoshida K, Yasui W.
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Journal Title
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Peer Reviewed
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[Presentation] Olfactomedin 4 and Reg IV2008
Author(s)
Oue N, Sentani K, Sakamoto N, Noguchi T and Yasui W
Organizer
Novel serum biomarkers for gastric cancer patients, 36th Congress of the International Society of Oncology and Biomarkers
Place of Presentation
Tokyo (Japan)
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