Gene expression profile of gastric cancer with gastric and intestinal phenotype

• Project/Area Number: 19790261
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Hiroshima University
• Principal Investigator: OUE Naohide Hiroshima University, 大学院・医歯薬総合研究科, 講師 (60346484)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: 腫瘍 / 胃癌 / 形質発現 / HOXA10 / GJP6 / HOXA 10 / GJB6

Research Abstract

本研究では、胃型・腸型形質を有する胃癌に関連している遺伝子を同定することを目的とした。腸型形質の胃癌で発現している遺伝子として、HOXA10とGJP6を同定した。免疫染色を行った結果、HOXA10は52%、GJP6は22%の胃癌で発現しており、腸型形質の胃癌で染色された。特にGJP6は、ギャップ結合を構成する膜貫通蛋白質であるコネキシン30をコードする遺伝子であり、治療標的として有用である。

Research Products

• [Journal Article] Transcriptome dissection of gastric cancer : identification of novel diagnostic and therapeutic targets from pathology specimens. (2009)
  • Author(s): Yasui W, Oue N, Sentani K, Sakamoto N, Motoshita J
  • Journal Title: Pathol Int 59 Pages: 121-136
  • Peer Reviewed
• [Journal Article] Reg IV enhances peritoneal metastasis in gastric carcinomas. (2009)
  • Author(s): Kuniyasu H, Oue N, Sasahira T, Yi L, Moriwaka Y, Shimomoto T, Fujii K, Ohmori H, Yasui W
  • Journal Title: Cell Prolif 42 Pages: 110-121
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of Reg IV in urogenital organs : Frequent expression of Reg IV in prostate cancer and potential utility as serum tumor marker (2009)
  • Author(s): Hayashi T, Matsubara A, Ohara S, Mita K, Hasegawa Y, Usui T, Arihiro K, NorimuraS, Sentani K, Oue N, Yasui W
  • Journal Title: Oncol Rep 21 Pages: 95-100
  • Peer Reviewed
• [Journal Article] Characteristic gene expression in stromal cells of gastric cancers among atomic-bomb survivors (2009)
  • Author(s): Oue N, Sentani K, Sakamoto N, Motoshita J, Nishisaka T, Fukuhara T, Matsuura H, Sasaki H, Nakachi K, Yasui W
  • Journal Title: Int J Cancer 124 Pages: 1112-1121
  • Peer Reviewed
• [Journal Article] h-prune Is an Independent Prognostic Marker for Survival in Esophageal Squamous Cell Carcinoma (2009)
  • Author(s): Noguchi T, Oue N, Wada S, Sentani K, Sakamoto N, Kikuchi A, Yasui W
  • Journal Title: Ann Surg Oncol 16 Pages: 1390-1396
  • Peer Reviewed
• [Journal Article] Characteristic gene expression in stromal cells of gastric cancers among atomic-bomb survivors (2009)
  • Author(s): Naohide Oue
  • Journal Title: Int J Cancer 124 Pages: 1112-1121
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of Reg IV in urogenital organs : Frequent expression of Reg IV in prostate cancer and potential utility as serum tumor marker (2009)
  • Author(s): Tetsutaro Hayashi
  • Journal Title: Oncol Rep 21 Pages: 95-100
  • Peer Reviewed
• [Journal Article] Reg IV enhances peritoneal metastasis in gastric carcinomas (2009)
  • Author(s): Hiroki Kuniyasu
  • Journal Title: Cell Prolif 42 Pages: 110-121
  • Peer Reviewed
• [Journal Article] Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells (2009)
  • Author(s): Hideki Yamamoto
  • Journal Title: Gastroenterology (in press)
  • Peer Reviewed
• [Journal Article] Reg IV expression is associated with cell growth and prognosis of adenoid cystic carcinoma in the salivary gland (2008)
  • Author(s): Sasahira T, Oue N, Kirita T, Luo Y, Bhawal UK, Fujii K, Yasui W, Kuniyasu H
  • Journal Title: Histopathology 53 Pages: 667-675
  • Peer Reviewed
• [Journal Article] Vascular endothelial growth factor C stimulates progression of human gastric cancer via both autocrine and paracrine mechanisms. (2008)
  • Author(s): Kodama M, Kitadai Y, Tanaka M, Kuwai T, Tanaka S, Oue N, Yasui W, Chayama K
  • Journal Title: Clin Cancer Res 14 Pages: 7205-7214
• [Journal Article] Positive immunohistochemical staining of gammaH2AX is associated with tumor progression in gastric cancers from radiation-exposed patients. (2008)
  • Author(s): Sentani K, Oue N, Sakamoto N, Nishisaka T, Fukuhara T, Matsuura H, Yasui W
  • Journal Title: Oncol Rep 20 Pages: 1131-1136
  • Peer Reviewed
• [Journal Article] Reg IV is an independent prognostic factor for relapse in patients with clinically localized prostate cancer (2008)
  • Author(s): Ohara S, Oue N, Matsubara A, Mita K, Hasegawa Y, Hayashi T, Usui T, Amatya VJ, Takeshima Y, Kuniyasu H, Yasui W
  • Journal Title: Cancer Sci 99 Pages: 1570-1577
  • Peer Reviewed
• [Journal Article] High mobility group box-1-inducible melanoma inhibitory activity is associated withm nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma (2008)
  • Author(s): Sasahira T, Kirita T, Oue N, Bhawal UK, Yamamoto K, Fujii K, Ohmori H, Luo Y, Yasui W, Bosserhoff AK, Kuniyasu H
  • Journal Title: Cancer Sci 99 Pages: 1806-1812
  • Peer Reviewed
• [Journal Article] Immunohistochemical staining of Reg IV and claudin-18 is useful in the diagnosis of gastrointestinal signet ring cell carcinoma (2008)
  • Author(s): Sentani K, Oue N, Tashiro T, Sakamoto N, Nishisaka T, Fukuhara T, Taniyama K, Matsuura H, Arihiro K, Ochiai A, Yasui W
  • Journal Title: Am J Surg Pathol 32 Pages: 1182-1189
  • Peer Reviewed
• [Journal Article] Overexpression of RegIV in peritoneal dissemination of gastric cancer and its potential as A novel marker for the detection of peritoneal micrometastasis (2008)
  • Author(s): Miyagawa K, Sakakura C, Nakashima S, Yoshikawa T, Fukuda K, Kin S, Nakase Y, Shimomura K, Oue N, Yasui W, Hayasizaki H, Okazaki Y, Yamagishi H, Hagiwara A, Otsuji E
  • Journal Title: Anticancer Res 28 Pages: 1169-1179
  • Peer Reviewed
• [Journal Article] Protection of telomeres 1 protein levels are associated with telomere length in gastric cancer (2008)
  • Author(s): Fujii K, Sasahira T, Moriwaka Y, Oue N, Yasui W, Kuniyasu H
  • Journal Title: Int J Mol Med 21 Pages: 599-604
  • Peer Reviewed
• [Journal Article] In silico analysis of gastric carcinoma Serial Analysis of Gene Expression libraries reveals different profiles associated with ethnicity (2008)
  • Author(s): Ossandon FJ, Villarroel C, Aguayo F, Santibanez E, Oue N, Yasui W, Corvalan AH
  • Journal Title: Mol Cancer 27 Pages: 7-22
  • Peer Reviewed
• [Journal Article] Gene expression profiling with microarray and SAGE identifies PLUNC as a marker for hepatoid adenocarcinoma of the stomach (2008)
  • Author(s): Sentani K, Oue N, Sakamoto N, Arihiro K, Aoyagi K, Sasaki H, Yasui W
  • Journal Title: Mod Pathol 21 Pages: 464-475
  • NAID: 130004927630
  • Peer Reviewed
• [Journal Article] Protection of telomeres1 protein levels are associated with telomere length in gastric cancer (2008)
  • Author(s): Kiyomu Fujii
  • Journal Title: Int J Mol Med 21 Pages: 599-604
  • Peer Reviewed
• [Journal Article] Overexpression of RegIV in peritoneal dissemination of gastric cancer and its potential as A novel marker for the detection of peritoneal micro metastasis (2008)
  • Author(s): Koji Miyagawa
  • Journal Title: Anticancer Res 28 Pages: 1169-1179
  • Peer Reviewed
• [Journal Article] Immunohistochemical staining of Reg IV and claudin-18 is useful in the diagnosis of gastrointestinal signet ring cell carcinoma (2008)
  • Author(s): Kazuhiro Sentani
  • Journal Title: Am J Surg Pathol 32 Pages: 1182-1189
  • Peer Reviewed
• [Journal Article] Reg IV is an independent prognostic factor for relapse in patients with clinically localized prostate cancer (2008)
  • Author(s): Shinya Ohara
  • Journal Title: Cancer Sci 99 Pages: 1570-1577
  • Peer Reviewed
• [Journal Article] High mobility group box-1-induciblc mclanoma inhibitory activity is associated with nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma (2008)
  • Author(s): Tomonori Sasahira
  • Journal Title: Cancer Sci 99 Pages: 1806-1812
  • Peer Reviewed
• [Journal Article] Positive immunohistochemical staining of gamma H2AX is associated with tumor progression in gastric cancers from radiation-exposed patients (2008)
  • Author(s): Kazuhiro Sentani
  • Journal Title: Oncol Rcp 20 Pages: 1131-1136
  • Peer Reviewed
• [Journal Article] Vascular endothelial growth factor C stimulates progression of human gastric cancer via both autocrine and paracrine mechanisms (2008)
  • Author(s): Michiyo Kodama
  • Journal Title: Clin Cancer Res 14 Pages: 7205-7214
  • Peer Reviewed
• [Journal Article] Reg IV expression is associated with cell growth and prognosis of adenoid cystic carcinoma in the salivary gland (2008)
  • Author(s): Tomonori Sasahira
  • Journal Title: Histopathology 53 Pages: 667-675
  • Peer Reviewed
• [Journal Article] h-prune is an independent prognostic marker for survival in esophageal squamous cell carcinoma. (2008)
  • Author(s): Tsuyoshi Noguchi
  • Journal Title: Annals of Surgical Oncology (in press)
  • Peer Reviewed
• [Journal Article] Gene expression profiling with microarray and SAGE identifies PLUNC as a marker for hepatoid adenocarcinoma of the stomach. (2008)
  • Author(s): Kazuhiro Sentani
  • Journal Title: Modern Pathology 21 Pages: 464-475
  • Peer Reviewed
• [Journal Article] Serum concentration of Reg IV in patients with colorectal cancer : overexpression and high serum levels of Reg IV are associated with liver metastasis (2007)
  • Author(s): ue N, Kuniyasu H, Noguchi T, Sentani K, Ito M, Tanaka S, Setoyama T, Sakakura C, Natsugoe S, Yasui W
  • Journal Title: Oncology 72 Pages: 371-380
  • Peer Reviewed
• [Journal Article] Synchronous squamous cell carcinoma of the breast and invasive lobular carcinoma (2007)
  • Author(s): Sentani K, Tashiro T, Oue N, Yasui W
  • Journal Title: APMIS 115 Pages: 1422-1425
  • Peer Reviewed
• [Journal Article] Melanoma-associated antigen-A1 expression predicts resistance to docetaxel and paclitaxel in advanced and recurrent gastric cancer (2007)
  • Author(s): Suzuki T, Yoshida K, Wada Y, Hamai Y, Sentani K, Oue N, Yasui W
  • Journal Title: Oncol Rep 18 Pages: 329-336
  • Peer Reviewed
• [Journal Article] Increased expression of h-prune is associated with tumor progression and poor survival in gastric cancer (2007)
  • Author(s): Oue N, Yoshida K, Noguchi T, Sentani K, Kikuchi A, Yasui W
  • Journal Title: Cancer Sci 98 Pages: 1198-1205
  • Peer Reviewed
• [Journal Article] Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy (2007)
  • Author(s): Mitani Y, Oue N, Matsumura S, Yoshida K, Noguchi T, Ito M, Tanaka S, Kuniyasu H,Kamata N, Yasui W
  • Journal Title: Oncogene 26 Pages: 4383-4393
  • Peer Reviewed
• [Journal Article] DNA demethylation of vascular endothelial growth factor-C is associated with gene expression and its possible involvement of lymphangiogenesis in gastric cancer (2007)
  • Author(s): Matsumura S, Oue N, Mitani Y, Kitadai Y, Yasui W
  • Journal Title: Int J Cancer 120 Pages: 1689-1695
  • Peer Reviewed
• [Journal Article] DNA methylation of the RIZ1 gene is associated with nuclear accumulation of p53 in prostate cancer (2007)
  • Author(s): Hasegawa Y, Matsubara A, Teishima J, Seki M, Mita K, Usui T, Oue N, Yasui W
  • Journal Title: Cancer Sci 98 Pages: 32-36
  • Peer Reviewed
• [Journal Article] DNA demethylation of vascular endothelial growth factor-C is associated with ene expression and its possible involvement of Iymphangiogenesis in gastric cance (2007)
  • Author(s): Shunji Matsumura
  • Journal Title: International Journal of Cancer 120 Pages: 1689-1695
  • Peer Reviewed
• [Journal Article] Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy. (2007)
  • Author(s): Yoshitsugu Mitani
  • Journal Title: Oncogene 26 Pages: 4383-4393
  • Peer Reviewed
• [Journal Article] Increased expression of h-prune is associated with tumor progression and poor survival in gastric cancer. (2007)
  • Author(s): Naohide Oue
  • Journal Title: Cancer Science 98 Pages: 1198-1205
  • Peer Reviewed
• [Journal Article] Melanoma-associated antigen-Al expression predicts resistance to docetaxel andpaclitaxel in advanced and recurrent gastric cancer. (2007)
  • Author(s): Takahisa Suzuki
  • Journal Title: Oncology Report 18 Pages: 329-336
  • Peer Reviewed
• [Journal Article] Synchronous squamous cell carcinoma of the breast and invasive lobular carcinoma. (2007)
  • Author(s): Kazuhiro Sentani
  • Journal Title: APMIS 115 Pages: 1422-1425
  • Peer Reviewed
• [Journal Article] Serum concentration of Reg IV in patients with colorectal cancer overexpression and high serum levels of Reg IV are associated with liver me tastasis. (2007)
  • Author(s): Naohide Oue
  • Journal Title: Oncology 72 Pages: 371-380
  • Peer Reviewed
• [Journal Article] Serum olfactomedin 4 (GW112, hGC-1)incombination with Reg IV is a highly sensitive biomarker for gastric cancer.
  • Author(s): Oue N, Sentani K, Noguchi T, Ohara S,Sakamoto N, Hayashi T, Anami K, Motoshita J, Ito M, Tanaka S, Yoshida K, Yasui W.
  • Journal Title: Int J Cancer (in press)
  • Peer Reviewed
• [Journal Article] Laminin g2 mediates Wnt5a-induced invasion of gastric cancer cells.
  • Author(s): Yamamoto H, Kitadai Y, Yamamoto H, Oue N, Ohdan H, Yasui W, Kikuchi A
  • Journal Title: Gastroenterology (in press)
  • Peer Reviewed
• [Presentation] SAGE-based microarray for gastric cancer identifies SEC11A as a marker for tumor progression (2008)
  • Author(s): 大上直秀
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] Olfactomedin 4は胃癌の新規血清腫瘍マーカーであり、血清Olfactomedin 4 とReg IVの組み合わせは感度の高い胃癌検出法である. (2008)
  • Author(s): 大上直秀、野口剛、仙谷和弘、坂本直也、伊藤公訓、田中信治、安井弥
  • Organizer: 第28回日本分子腫瘍マーカー研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-27
• [Presentation] Olfactomedin 4は胃癌の新規血清腫瘍マーカーであり、血清Olfactomedin 14とReg IVの組み合わせは感度の高い胃癌検出法である (2008)
  • Author(s): 大上直秀
  • Organizer: 第28回日本分子腫瘍マーカー研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-27
• [Presentation] Olfactomedin 4 and Reg IV : Novel serum biomarkers for gastric cancer patients (2008)
  • Author(s): Naohide Oue
  • Organizer: 36th Congress of the International Society of Oncoloey and Biomarkers
  • Place of Presentation: 東京
  • Year and Date: 2008-10-06
• [Presentation] 遺伝子発現の意義 : SEC11A(SPC18)の胃癌における発現の意義とEGF/TGF-αの分泌促進 (2008)
  • Author(s): 大上直秀
  • Organizer: 第19回冒本消化器癌発生学会
  • Place of Presentation: 別府
  • Year and Date: 2008-08-28
• [Presentation] SAGE-based microarrayで同定したSEC11A(SPC18)によるEGF、TGF-αの分泌促進と胃癌進行との関連 (2008)
  • Author(s): 大上直秀
  • Organizer: 第17回日本がん転移学会
  • Place of Presentation: 鹿児島
  • Year and Date: 2008-07-24
• [Presentation] SAGE-based microarrayにより同定したSEC11A(SPC18)は胃癌の進行と関連している (2008)
  • Author(s): 大上直秀
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-15
• [Presentation] 遺伝子発現プロファイルで同定されたconnexin 30は腸型形質を有する胃癌のマーカーである (2008)
  • Author(s): 大上直秀
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-15
• [Presentation] SAGE-based arrayを用いた胃癌関連遺伝子の探索:SEC11Aは胃癌の進行に関与している (2008)
  • Author(s): 大上直秀、柳原五吉、仙谷和弘、坂本直也、安井弥
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] Olfactomedin 4 and Reg IV (2008)
  • Author(s): Oue N, Sentani K, Sakamoto N, Noguchi T and Yasui W
  • Organizer: Novel serum biomarkers for gastric cancer patients, 36th Congress of the International Society of Oncology and Biomarkers
  • Place of Presentation: Tokyo (Japan)
• [Presentation] 遺伝子発現の意義:SEC11A(SPC18)の胃癌における発現の意義とEGF/TGFαの分泌促進. (2008)
  • Author(s): 大上直秀、仙谷和弘、柳原五吉、坂本直也、安井弥
  • Organizer: 第19回日本消化器癌発生学会、ミニシンポジウム3
  • Place of Presentation: 別府
• [Presentation] SAGE-based microarrayで同定したSEC11A (SPC18)によるEGF、TGF-αの分泌促進と胃癌進行との相関 (2008)
  • Author(s): 大上直秀、仙谷和弘、坂本直也、柳原五吉、安井弥
  • Organizer: 第17回日本がん転移学会
  • Place of Presentation: 鹿児島
• [Presentation] SAGE-based microarrayにより同定したSEC11A (SPC18)は胃癌の進行と関連している (2008)
  • Author(s): 大上直秀、仙谷和弘、柳原五吉、坂本直也、安井弥
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] 遺伝子発現プロファイルで同定されたconnexin30は腸型形質を有する胃癌のマーカーである (2008)
  • Author(s): 大上直秀、仙谷和弘、阿南勝宏、安井弥
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] Reg IVは大腸癌の血清腫瘍マーカーであり予後予測に有用である (2008)
  • Author(s): 大上直秀、國安弘基、仙谷和弘、坂本直也、安井弥
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] 胃がんの新規血清診断マーカーReg IV (2008)
  • Author(s): 大上直秀、安井弥
  • Organizer: 第80回日本胃癌学会総会、シンポジウム「個別化医療に向けた胃がん診断の最前線」
  • Place of Presentation: 横浜
• [Presentation] Serum concentration of Reg IV in patients with colorectal cancers. (2007)
  • Author(s): Naohide Oue
  • Organizer: The 17th International Symposium of the Hiroshima Cancer Seminar
  • Place of Presentation: 広島
  • Year and Date: 2007-11-11
• [Presentation] 消化器癌発生の基礎と臨床:SAGE法で同定したRegIV遺伝子の上流/下流の解析と診断への応用 (2007)
  • Author(s): 大上 直秀
  • Organizer: 第18回日本消化器癌発生学会
  • Place of Presentation: 札幌
  • Year and Date: 2007-11-08
• [Presentation] SAGE-based microarray for gastric cancer identifies SEC11A as a marker for tumor progression. (2007)
  • Author(s): 大上 直秀
  • Organizer: 第66回日本癌学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] 血清腫瘍マーカーとしてのReg IVの有用性:大腸癌においてReg IV高値は肝転移と関連している (2007)
  • Author(s): 大上直秀、國安弘基、野口剛、仙谷和弘、伊藤公訓、田中信治、瀬戸山徹郎、阪倉長平、夏越祥次、安井弥
  • Organizer: 第27回日本分子腫瘍マーカー研究会、ワークショップ1「分子腫瘍マーカー認識抗体の作成と応用」
  • Place of Presentation: 東京
  • Year and Date: 2007-10-02
• [Presentation] 血清腫瘍マーカーとしてのRegIVの有用性:大腸癌においてRegIV高値は肝転と関連している (2007)
  • Author(s): 大上 直秀
  • Organizer: 第27回日本分子腫瘍マーカー研究会
  • Place of Presentation: 東京
  • Year and Date: 2007-10-02
• [Presentation] 転移遺伝子:胃癌においてWnt-5aはβ-catenin異常蓄積のない症例で高発現しており予後不良と相関している (2007)
  • Author(s): 大上 直秀
  • Organizer: 第I6回日本がん転移学会総会
  • Place of Presentation: 富山
  • Year and Date: 2007-07-09
• [Presentation] 消化器癌発生の基礎と臨床:SAGE法で同定したReg IV遺伝子の上流/下流の解析と診断への応用. (2007)
  • Author(s): 大上直秀、仙谷和弘、坂本直也、檜井孝夫、安井弥
  • Organizer: 第18回日本消化器癌発生学会、シンポジウム1
  • Place of Presentation: 札幌
• [Presentation] SAGE-based microarray for gastric cancer identifies SEC11A as a marker for tumor progression. ワークショップ14「Human cancer Research: Gastric cancer (2007)
  • Author(s): 大上直秀、仙谷和弘、坂本直也、吉田和弘、安井弥
  • Organizer: 第66回日本癌学会総会
  • Place of Presentation: 横浜
• [Presentation] 胃癌においてWnt-5aはb-catenin異常蓄積のない症例で高発現しており予後不良と相関している (2007)
  • Author(s): 大上直秀、菊池章、安井弥
  • Organizer: 第16回日本がん転移学会総会、ワークショップ1
  • Place of Presentation: 富山
• [Presentation] Serum Concentration of Reg IV in patients with colorectal cancers (2007)
  • Author(s): Oue N, Sentani K, Sakamoto N and Yasui W
  • Organizer: The 98th Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: Los Angeles, California (USA)
• [Presentation] SAGE法により同定したReg IVはEGFRをリン酸化し5-FU誘導性のアポートシスを制御する. (2007)
  • Author(s): 大上直秀、國安弘基、安井弥
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
• [Presentation] 胃癌におけるh-prune、nm23-H1の発現と臨床病理学的因子との関連. (2007)
  • Author(s): 大上直秀、安井弥
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
• [Book] 胃癌に関連する遺伝子.幕内雅敏、荒井邦佳・編、Knack & Pitfalls「胃外科の要点と盲点」第2版 (2008)
  • Author(s): 大上直秀、安井弥
  • Publisher: 文光堂、東京(印刷中)
• [Book] 胃外科の要点と盲点第2版 (2008)
  • Author(s): 大上直秀
  • Publisher: 文光堂(印刷中)
• [Book] International Congress Series: Radiation Risk Perspectives (2007)
  • Author(s): Wataru Yasui
  • Publisher: Elsevier
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/byori1/
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/byoril/